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5Q06

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonylurea

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003824molecular_functioncatalytic activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0005986biological_processsucrose biosynthetic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0006111biological_processregulation of gluconeogenesis
A0008152biological_processmetabolic process
A0016208molecular_functionAMP binding
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030308biological_processnegative regulation of cell growth
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0031667biological_processresponse to nutrient levels
A0032869biological_processcellular response to insulin stimulus
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0045820biological_processnegative regulation of glycolytic process
A0046580biological_processnegative regulation of Ras protein signal transduction
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070062cellular_componentextracellular exosome
A0071286biological_processcellular response to magnesium ion
A0071320biological_processcellular response to cAMP
A0071466biological_processcellular response to xenobiotic stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071477biological_processcellular hypotonic salinity response
A0097403biological_processcellular response to raffinose
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003824molecular_functioncatalytic activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0005986biological_processsucrose biosynthetic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0006111biological_processregulation of gluconeogenesis
B0008152biological_processmetabolic process
B0016208molecular_functionAMP binding
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030308biological_processnegative regulation of cell growth
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0031667biological_processresponse to nutrient levels
B0032869biological_processcellular response to insulin stimulus
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0045820biological_processnegative regulation of glycolytic process
B0046580biological_processnegative regulation of Ras protein signal transduction
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070062cellular_componentextracellular exosome
B0071286biological_processcellular response to magnesium ion
B0071320biological_processcellular response to cAMP
B0071466biological_processcellular response to xenobiotic stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071477biological_processcellular hypotonic salinity response
B0097403biological_processcellular response to raffinose
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0003824molecular_functioncatalytic activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005975biological_processcarbohydrate metabolic process
C0005986biological_processsucrose biosynthetic process
C0006000biological_processfructose metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0006111biological_processregulation of gluconeogenesis
C0008152biological_processmetabolic process
C0016208molecular_functionAMP binding
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030308biological_processnegative regulation of cell growth
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0031667biological_processresponse to nutrient levels
C0032869biological_processcellular response to insulin stimulus
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042578molecular_functionphosphoric ester hydrolase activity
C0042802molecular_functionidentical protein binding
C0045820biological_processnegative regulation of glycolytic process
C0046580biological_processnegative regulation of Ras protein signal transduction
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0070062cellular_componentextracellular exosome
C0071286biological_processcellular response to magnesium ion
C0071320biological_processcellular response to cAMP
C0071466biological_processcellular response to xenobiotic stimulus
C0071475biological_processcellular hyperosmotic salinity response
C0071477biological_processcellular hypotonic salinity response
C0097403biological_processcellular response to raffinose
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0003824molecular_functioncatalytic activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005975biological_processcarbohydrate metabolic process
D0005986biological_processsucrose biosynthetic process
D0006000biological_processfructose metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0006111biological_processregulation of gluconeogenesis
D0008152biological_processmetabolic process
D0016208molecular_functionAMP binding
D0016311biological_processdephosphorylation
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030308biological_processnegative regulation of cell growth
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0031667biological_processresponse to nutrient levels
D0032869biological_processcellular response to insulin stimulus
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042578molecular_functionphosphoric ester hydrolase activity
D0042802molecular_functionidentical protein binding
D0045820biological_processnegative regulation of glycolytic process
D0046580biological_processnegative regulation of Ras protein signal transduction
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0070062cellular_componentextracellular exosome
D0071286biological_processcellular response to magnesium ion
D0071320biological_processcellular response to cAMP
D0071466biological_processcellular response to xenobiotic stimulus
D0071475biological_processcellular hyperosmotic salinity response
D0071477biological_processcellular hypotonic salinity response
D0097403biological_processcellular response to raffinose
D1904628biological_processcellular response to phorbol 13-acetate 12-myristate
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue 95V A 401
ChainResidue
APHE16
ATHR31
AMET177
ACYS179
AHOH506
C95V401
AGLU20
AGLY21
AARG22
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30

site_idAC2
Number of Residues14
Detailsbinding site for residue 95V B 401
ChainResidue
BPHE16
BGLU20
BGLY21
BARG22
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BMET177
BCYS179
BHOH553
D95V401

site_idAC3
Number of Residues17
Detailsbinding site for residue 95V C 401
ChainResidue
ATHR27
A95V401
CPHE16
CMET18
CGLU20
CGLY21
CARG22
CALA24
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CMET177
CCYS179
CHOH554

site_idAC4
Number of Residues16
Detailsbinding site for residue 95V D 401
ChainResidue
BTHR27
BGLY28
B95V401
DPHE16
DMET18
DGLU20
DGLY21
DARG22
DGLY26
DGLY28
DGLU29
DLEU30
DTHR31
DMET177
DCYS179
DHOH529

Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA
ChainResidueDetails
AGLY273-ALA285

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:7809062, ECO:0007744|PDB:1FTA
ChainResidueDetails
AVAL17
CTHR27
CLYS112
CARG140
DVAL17
DTHR27
DLYS112
DARG140
ATHR27
ALYS112
AARG140
BVAL17
BTHR27
BLYS112
BARG140
CVAL17

site_idSWS_FT_FI2
Number of Residues28
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00636
ChainResidueDetails
AASP68
BLEU120
BASN212
BARG243
BTYR264
BLYS274
CASP68
CGLU97
CLEU120
CASN212
CARG243
AGLU97
CTYR264
CLYS274
DASP68
DGLU97
DLEU120
DASN212
DARG243
DTYR264
DLYS274
ALEU120
AASN212
AARG243
ATYR264
ALYS274
BASP68
BGLU97

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0007744|PDB:2FHY
ChainResidueDetails
AASP118
DASP118
DASP121
DGLU280
AASP121
AGLU280
BASP118
BASP121
BGLU280
CASP118
CASP121
CGLU280

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P00637
ChainResidueDetails
AALA1
BALA1
CALA1
DALA1

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
ALYS150
BLYS150
CLYS150
DLYS150

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
ATYR215
ATYR244
BTYR215
BTYR244
CTYR215
CTYR244
DTYR215
DTYR244

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATYR264
BTYR264
CTYR264
DTYR264

217705

数据于2024-03-27公开中

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