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5PZX

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-methoxy-3-(2-methylpropyl)phenyl]sulfonylurea

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003824molecular_functioncatalytic activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0005986biological_processsucrose biosynthetic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0006111biological_processregulation of gluconeogenesis
A0008152biological_processmetabolic process
A0016208molecular_functionAMP binding
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030308biological_processnegative regulation of cell growth
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0031667biological_processresponse to nutrient levels
A0032869biological_processcellular response to insulin stimulus
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0045820biological_processnegative regulation of glycolytic process
A0046580biological_processnegative regulation of Ras protein signal transduction
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070062cellular_componentextracellular exosome
A0071286biological_processcellular response to magnesium ion
A0071320biological_processcellular response to cAMP
A0071466biological_processcellular response to xenobiotic stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071477biological_processcellular hypotonic salinity response
A0097403biological_processcellular response to raffinose
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003824molecular_functioncatalytic activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0005986biological_processsucrose biosynthetic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0006111biological_processregulation of gluconeogenesis
B0008152biological_processmetabolic process
B0016208molecular_functionAMP binding
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030308biological_processnegative regulation of cell growth
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0031667biological_processresponse to nutrient levels
B0032869biological_processcellular response to insulin stimulus
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0045820biological_processnegative regulation of glycolytic process
B0046580biological_processnegative regulation of Ras protein signal transduction
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070062cellular_componentextracellular exosome
B0071286biological_processcellular response to magnesium ion
B0071320biological_processcellular response to cAMP
B0071466biological_processcellular response to xenobiotic stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071477biological_processcellular hypotonic salinity response
B0097403biological_processcellular response to raffinose
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0003824molecular_functioncatalytic activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005975biological_processcarbohydrate metabolic process
C0005986biological_processsucrose biosynthetic process
C0006000biological_processfructose metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0006111biological_processregulation of gluconeogenesis
C0008152biological_processmetabolic process
C0016208molecular_functionAMP binding
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030308biological_processnegative regulation of cell growth
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0031667biological_processresponse to nutrient levels
C0032869biological_processcellular response to insulin stimulus
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042578molecular_functionphosphoric ester hydrolase activity
C0042802molecular_functionidentical protein binding
C0045820biological_processnegative regulation of glycolytic process
C0046580biological_processnegative regulation of Ras protein signal transduction
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0070062cellular_componentextracellular exosome
C0071286biological_processcellular response to magnesium ion
C0071320biological_processcellular response to cAMP
C0071466biological_processcellular response to xenobiotic stimulus
C0071475biological_processcellular hyperosmotic salinity response
C0071477biological_processcellular hypotonic salinity response
C0097403biological_processcellular response to raffinose
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0003824molecular_functioncatalytic activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005975biological_processcarbohydrate metabolic process
D0005986biological_processsucrose biosynthetic process
D0006000biological_processfructose metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0006111biological_processregulation of gluconeogenesis
D0008152biological_processmetabolic process
D0016208molecular_functionAMP binding
D0016311biological_processdephosphorylation
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030308biological_processnegative regulation of cell growth
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0031667biological_processresponse to nutrient levels
D0032869biological_processcellular response to insulin stimulus
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042578molecular_functionphosphoric ester hydrolase activity
D0042802molecular_functionidentical protein binding
D0045820biological_processnegative regulation of glycolytic process
D0046580biological_processnegative regulation of Ras protein signal transduction
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0070062cellular_componentextracellular exosome
D0071286biological_processcellular response to magnesium ion
D0071320biological_processcellular response to cAMP
D0071466biological_processcellular response to xenobiotic stimulus
D0071475biological_processcellular hyperosmotic salinity response
D0071477biological_processcellular hypotonic salinity response
D0097403biological_processcellular response to raffinose
D1904628biological_processcellular response to phorbol 13-acetate 12-myristate
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0003824molecular_functioncatalytic activity
E0005515molecular_functionprotein binding
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005975biological_processcarbohydrate metabolic process
E0005986biological_processsucrose biosynthetic process
E0006000biological_processfructose metabolic process
E0006002biological_processfructose 6-phosphate metabolic process
E0006094biological_processgluconeogenesis
E0006111biological_processregulation of gluconeogenesis
E0008152biological_processmetabolic process
E0016208molecular_functionAMP binding
E0016311biological_processdephosphorylation
E0016787molecular_functionhydrolase activity
E0016791molecular_functionphosphatase activity
E0030308biological_processnegative regulation of cell growth
E0030388biological_processfructose 1,6-bisphosphate metabolic process
E0031667biological_processresponse to nutrient levels
E0032869biological_processcellular response to insulin stimulus
E0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
E0042578molecular_functionphosphoric ester hydrolase activity
E0042802molecular_functionidentical protein binding
E0045820biological_processnegative regulation of glycolytic process
E0046580biological_processnegative regulation of Ras protein signal transduction
E0046872molecular_functionmetal ion binding
E0048029molecular_functionmonosaccharide binding
E0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
E0070062cellular_componentextracellular exosome
E0071286biological_processcellular response to magnesium ion
E0071320biological_processcellular response to cAMP
E0071466biological_processcellular response to xenobiotic stimulus
E0071475biological_processcellular hyperosmotic salinity response
E0071477biological_processcellular hypotonic salinity response
E0097403biological_processcellular response to raffinose
E1904628biological_processcellular response to phorbol 13-acetate 12-myristate
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0003824molecular_functioncatalytic activity
F0005515molecular_functionprotein binding
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005975biological_processcarbohydrate metabolic process
F0005986biological_processsucrose biosynthetic process
F0006000biological_processfructose metabolic process
F0006002biological_processfructose 6-phosphate metabolic process
F0006094biological_processgluconeogenesis
F0006111biological_processregulation of gluconeogenesis
F0008152biological_processmetabolic process
F0016208molecular_functionAMP binding
F0016311biological_processdephosphorylation
F0016787molecular_functionhydrolase activity
F0016791molecular_functionphosphatase activity
F0030308biological_processnegative regulation of cell growth
F0030388biological_processfructose 1,6-bisphosphate metabolic process
F0031667biological_processresponse to nutrient levels
F0032869biological_processcellular response to insulin stimulus
F0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
F0042578molecular_functionphosphoric ester hydrolase activity
F0042802molecular_functionidentical protein binding
F0045820biological_processnegative regulation of glycolytic process
F0046580biological_processnegative regulation of Ras protein signal transduction
F0046872molecular_functionmetal ion binding
F0048029molecular_functionmonosaccharide binding
F0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
F0070062cellular_componentextracellular exosome
F0071286biological_processcellular response to magnesium ion
F0071320biological_processcellular response to cAMP
F0071466biological_processcellular response to xenobiotic stimulus
F0071475biological_processcellular hyperosmotic salinity response
F0071477biological_processcellular hypotonic salinity response
F0097403biological_processcellular response to raffinose
F1904628biological_processcellular response to phorbol 13-acetate 12-myristate
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0003824molecular_functioncatalytic activity
G0005515molecular_functionprotein binding
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005975biological_processcarbohydrate metabolic process
G0005986biological_processsucrose biosynthetic process
G0006000biological_processfructose metabolic process
G0006002biological_processfructose 6-phosphate metabolic process
G0006094biological_processgluconeogenesis
G0006111biological_processregulation of gluconeogenesis
G0008152biological_processmetabolic process
G0016208molecular_functionAMP binding
G0016311biological_processdephosphorylation
G0016787molecular_functionhydrolase activity
G0016791molecular_functionphosphatase activity
G0030308biological_processnegative regulation of cell growth
G0030388biological_processfructose 1,6-bisphosphate metabolic process
G0031667biological_processresponse to nutrient levels
G0032869biological_processcellular response to insulin stimulus
G0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
G0042578molecular_functionphosphoric ester hydrolase activity
G0042802molecular_functionidentical protein binding
G0045820biological_processnegative regulation of glycolytic process
G0046580biological_processnegative regulation of Ras protein signal transduction
G0046872molecular_functionmetal ion binding
G0048029molecular_functionmonosaccharide binding
G0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
G0070062cellular_componentextracellular exosome
G0071286biological_processcellular response to magnesium ion
G0071320biological_processcellular response to cAMP
G0071466biological_processcellular response to xenobiotic stimulus
G0071475biological_processcellular hyperosmotic salinity response
G0071477biological_processcellular hypotonic salinity response
G0097403biological_processcellular response to raffinose
G1904628biological_processcellular response to phorbol 13-acetate 12-myristate
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0003824molecular_functioncatalytic activity
H0005515molecular_functionprotein binding
H0005615cellular_componentextracellular space
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005975biological_processcarbohydrate metabolic process
H0005986biological_processsucrose biosynthetic process
H0006000biological_processfructose metabolic process
H0006002biological_processfructose 6-phosphate metabolic process
H0006094biological_processgluconeogenesis
H0006111biological_processregulation of gluconeogenesis
H0008152biological_processmetabolic process
H0016208molecular_functionAMP binding
H0016311biological_processdephosphorylation
H0016787molecular_functionhydrolase activity
H0016791molecular_functionphosphatase activity
H0030308biological_processnegative regulation of cell growth
H0030388biological_processfructose 1,6-bisphosphate metabolic process
H0031667biological_processresponse to nutrient levels
H0032869biological_processcellular response to insulin stimulus
H0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
H0042578molecular_functionphosphoric ester hydrolase activity
H0042802molecular_functionidentical protein binding
H0045820biological_processnegative regulation of glycolytic process
H0046580biological_processnegative regulation of Ras protein signal transduction
H0046872molecular_functionmetal ion binding
H0048029molecular_functionmonosaccharide binding
H0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
H0070062cellular_componentextracellular exosome
H0071286biological_processcellular response to magnesium ion
H0071320biological_processcellular response to cAMP
H0071466biological_processcellular response to xenobiotic stimulus
H0071475biological_processcellular hyperosmotic salinity response
H0071477biological_processcellular hypotonic salinity response
H0097403biological_processcellular response to raffinose
H1904628biological_processcellular response to phorbol 13-acetate 12-myristate
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue 94S A 401
ChainResidue
AVAL17
ATHR31
AMET177
CTHR27
C94S401
AMET18
AGLU20
AGLY21
AARG22
AGLY26
ATHR27
AGLY28
ALEU30

site_idAC2
Number of Residues12
Detailsbinding site for residue 94S B 401
ChainResidue
BVAL17
BMET18
BGLU20
BGLY21
BARG22
BALA24
BGLY26
BGLY28
BLEU30
BTHR31
BMET177
D94S401

site_idAC3
Number of Residues14
Detailsbinding site for residue 94S C 401
ChainResidue
AGLY28
A94S401
CVAL17
CMET18
CGLU20
CGLY21
CARG22
CALA24
CGLY26
CTHR27
CGLY28
CLEU30
CTHR31
CLEU34

site_idAC4
Number of Residues15
Detailsbinding site for residue 94S D 401
ChainResidue
BTHR27
B94S401
DVAL17
DMET18
DGLU20
DGLY21
DARG22
DALA24
DGLY26
DTHR27
DGLY28
DLEU30
DTHR31
DMET177
DHOH511

site_idAC5
Number of Residues11
Detailsbinding site for residue 94S E 401
ChainResidue
EVAL17
EGLU20
EGLY21
EARG22
EGLY26
ETHR27
EGLY28
ELEU30
ETHR31
EMET177
G94S401

site_idAC6
Number of Residues9
Detailsbinding site for residue 94S F 401
ChainResidue
FMET18
FGLY21
FARG22
FGLY26
FGLY28
FLEU30
FTHR31
FMET177
H94S401

site_idAC7
Number of Residues13
Detailsbinding site for residue 94S G 401
ChainResidue
E94S401
GVAL17
GMET18
GGLU20
GGLY21
GARG22
GGLY26
GTHR27
GGLY28
GLEU30
GTHR31
GLEU34
GMET177

site_idAC8
Number of Residues10
Detailsbinding site for residue 94S H 401
ChainResidue
F94S401
HVAL17
HGLU20
HGLY21
HARG22
HGLY26
HGLY28
HLEU30
HTHR31
HMET177

Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA
ChainResidueDetails
AGLY273-ALA285

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsBINDING: BINDING => ECO:0000269|PubMed:7809062, ECO:0007744|PDB:1FTA
ChainResidueDetails
AVAL17
CTHR27
CLYS112
CARG140
DVAL17
DTHR27
DLYS112
DARG140
EVAL17
ETHR27
ELYS112
ATHR27
EARG140
FVAL17
FTHR27
FLYS112
FARG140
GVAL17
GTHR27
GLYS112
GARG140
HVAL17
ALYS112
HTHR27
HLYS112
HARG140
AARG140
BVAL17
BTHR27
BLYS112
BARG140
CVAL17

site_idSWS_FT_FI2
Number of Residues56
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00636
ChainResidueDetails
AASP68
BLEU120
BASN212
BARG243
BTYR264
BLYS274
CASP68
CGLU97
CLEU120
CASN212
CARG243
AGLU97
CTYR264
CLYS274
DASP68
DGLU97
DLEU120
DASN212
DARG243
DTYR264
DLYS274
EASP68
ALEU120
EGLU97
ELEU120
EASN212
EARG243
ETYR264
ELYS274
FASP68
FGLU97
FLEU120
FASN212
AASN212
FARG243
FTYR264
FLYS274
GASP68
GGLU97
GLEU120
GASN212
GARG243
GTYR264
GLYS274
AARG243
HASP68
HGLU97
HLEU120
HASN212
HARG243
HTYR264
HLYS274
ATYR264
ALYS274
BASP68
BGLU97

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING: BINDING => ECO:0007744|PDB:2FHY
ChainResidueDetails
AASP118
DASP118
DASP121
DGLU280
EASP118
EASP121
EGLU280
FASP118
FASP121
FGLU280
GASP118
AASP121
GASP121
GGLU280
HASP118
HASP121
HGLU280
AGLU280
BASP118
BASP121
BGLU280
CASP118
CASP121
CGLU280

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P00637
ChainResidueDetails
AALA1
BALA1
CALA1
DALA1
EALA1
FALA1
GALA1
HALA1

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
ALYS150
BLYS150
CLYS150
DLYS150
ELYS150
FLYS150
GLYS150
HLYS150

site_idSWS_FT_FI6
Number of Residues16
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9QXD6
ChainResidueDetails
ATYR215
ETYR244
FTYR215
FTYR244
GTYR215
GTYR244
HTYR215
HTYR244
ATYR244
BTYR215
BTYR244
CTYR215
CTYR244
DTYR215
DTYR244
ETYR215

site_idSWS_FT_FI7
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATYR264
BTYR264
CTYR264
DTYR264
ETYR264
FTYR264
GTYR264
HTYR264

217705

數據於2024-03-27公開中

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