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5NAW

Complement factor D in complex with the inhibitor (1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-trifluoromethoxy-phenyl)-amide]

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009617biological_processresponse to bacterium
A0016787molecular_functionhydrolase activity
A0031093cellular_componentplatelet alpha granule lumen
A0034774cellular_componentsecretory granule lumen
A0045087biological_processinnate immune response
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue 8RZ A 301
ChainResidue
AHIS40
ACYS191
ALYS192
AGLY193
ASER195
AVAL213
ATHR214
ASER215
AGLY216
ASER217
AARG218
ALEU41
ACYS220
AHOH502
AHOH508
AHOH567
AHIS57
ACYS58
ATRP141
AGLY142
AILE143
AARG151
ASER190

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195

218853

건을2024-04-24부터공개중

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