5FOB

Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
C	0001848	molecular_function	complement binding
C	0016020	cellular_component	membrane
C	0045916	biological_process	negative regulation of complement activation

Functional Information from PROSITE/UniProt

site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEEnM

Chain	Residue	Details
B	PRO1007-MET1015

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by factor I => ECO:0000255

Chain	Residue	Details
B	ARG954

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by factor I

Chain	Residue	Details
A	SER297
A	SER303
B	ARG1320
B	ARG1303

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604

Chain	Residue	Details
B	ASN1663

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site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
B	SER1573
B	SER968
B	SER1321

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150

Chain	Residue	Details
B	ASN939

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
B	ASN1617

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)

Chain	Residue	Details
B	CYS1010
B	GLU1013

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