5FO9

Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
D	0004866	molecular_function	endopeptidase inhibitor activity
E	0004866	molecular_function	endopeptidase inhibitor activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space

Functional Information from PROSITE/UniProt

site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEEnM

Chain	Residue	Details
B	PRO1007-MET1015

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN959
C	ASN1028
F	ASN959
F	ASN1028

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Cleavage; by factor I

Chain	Residue	Details
B	ARG1303
B	ARG1320
E	ARG1303
E	ARG1320
D	SER38
D	SER70
D	SER297
D	SER303

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604

Chain	Residue	Details
B	ASN1663
E	ASN1663

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
B	SER968
B	SER1321
B	SER1573
E	SER968
E	SER1321
E	SER1573

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150

Chain	Residue	Details
B	ASN939
E	ASN939

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
B	ASN1617
E	ASN1617

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)

Chain	Residue	Details
B	CYS1010
B	GLU1013
E	CYS1010
E	GLU1013

---