5CUQ
Identification and characterization of novel broad spectrum inhibitors of the flavivirus methyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue NSC A 301 |
| Chain | Residue |
| A | GLY81 |
| A | GLY109 |
| A | HIS110 |
| A | GLU111 |
| A | LYS130 |
| A | ASP131 |
| A | VAL132 |
| A | PHE133 |
| A | ILE147 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue NSC B 301 |
| Chain | Residue |
| B | GLY81 |
| B | THR104 |
| B | LYS105 |
| B | GLY109 |
| B | HIS110 |
| B | GLU111 |
| B | ASP131 |
| B | VAL132 |
| B | PHE133 |
| B | HOH441 |
| B | HOH497 |
| B | HOH578 |
| B | HOH598 |
