5BNJ

CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
B	0016592	cellular_component	mediator complex
B	0042802	molecular_function	identical protein binding
B	0045023	biological_process	G0 to G1 transition
B	0045746	biological_process	negative regulation of Notch signaling pathway
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	1990508	cellular_component	CKM complex

PDBデータベースに由来する情報

site_id	AC1
残基数	10
詳細	binding site for residue 4TV A 501

鎖名	残基
A	VAL27
A	ARG356
A	TYR32
A	ALA50
A	LYS52
A	PHE97
A	ASP98
A	ALA100
A	HIS106
A	ASP173

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site_id	AC2
残基数	2
詳細	binding site for residue FMT B 301

鎖名	残基
A	GLU14
B	GLU144

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site_id	AC3
残基数	2
詳細	binding site for residue FMT B 302

鎖名	残基
A	ARG71
B	ASP147

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00107
残基数	26
詳細	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK

鎖名	残基	詳細
A	VAL27-LYS52

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site_id	PS00108
残基数	13
詳細	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV

鎖名	残基	詳細
A	VAL147-VAL159

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	1
詳細	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332

鎖名	残基	詳細
B	SER275

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site_id	SWS_FT_FI2
残基数	2
詳細	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

鎖名	残基	詳細
A	LYS52
A	VAL27

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