5AA8
Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 5P8 A 2402 |
| Chain | Residue |
| A | LEU1122 |
| A | ASN1254 |
| A | LEU1256 |
| A | GLY1269 |
| A | ASP1270 |
| A | HOH2032 |
| A | HOH2061 |
| A | GLY1123 |
| A | VAL1130 |
| A | ALA1148 |
| A | GLU1197 |
| A | PHE1198 |
| A | MET1199 |
| A | GLY1202 |
| A | ARG1253 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGHGAFGEVYeGqvsgmpndpsplq.....VAVK |
| Chain | Residue | Details |
| A | LEU1122-LYS1150 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDIAARNCLL |
| Chain | Residue | Details |
| A | PHE1245-LEU1257 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYrasYYR |
| Chain | Residue | Details |
| A | ASP1276-ARG1284 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP1249 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS1124 | |
| A | GLU1197 | |
| Chain | Residue | Details |
| A | LYS1150 | |
| Chain | Residue | Details |
| A | ASP1270 | |
| Chain | Residue | Details |
| A | TYR1096 | |
| Chain | Residue | Details |
| A | TYR1131 | |
| Chain | Residue | Details |
| A | TYR1278 | |
