5A6U

Native mammalian ribosome-bound Sec61 protein-conducting channel in the 'non-inserting' state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005048	molecular_function	signal sequence binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005784	cellular_component	Sec61 translocon complex
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006613	biological_process	cotranslational protein targeting to membrane
A	0006616	biological_process	SRP-dependent cotranslational protein targeting to membrane, translocation
A	0008320	molecular_function	protein transmembrane transporter activity
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0031204	biological_process	post-translational protein targeting to membrane, translocation
A	0039019	biological_process	pronephric nephron development
A	0043022	molecular_function	ribosome binding
A	0045047	biological_process	protein targeting to ER
A	0045048	biological_process	protein insertion into ER membrane
B	0005784	cellular_component	Sec61 translocon complex
B	0006886	biological_process	intracellular protein transport
G	0005543	molecular_function	phospholipid binding
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006605	biological_process	protein targeting
G	0006886	biological_process	intracellular protein transport
G	0008320	molecular_function	protein transmembrane transporter activity
G	0015031	biological_process	protein transport
G	0016020	cellular_component	membrane
G	0022406	biological_process	membrane docking
G	0031204	biological_process	post-translational protein targeting to membrane, translocation
G	0043022	molecular_function	ribosome binding
G	0045047	biological_process	protein targeting to ER
G	0071261	cellular_component	Ssh1 translocon complex

Functional Information from PROSITE/UniProt

site_id	PS01067
Number of Residues	29
Details	SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI

Chain	Residue	Details
G	PHE14-ILE42

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site_id	PS00755
Number of Residues	20
Details	SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL

Chain	Residue	Details
A	THR75-LEU94

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site_id	PS00756
Number of Residues	19
Details	SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF

Chain	Residue	Details
A	LEU164-PHE182

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	TRANSMEM: Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT

Chain	Residue	Details
G	ILE36-ILE61
A	GLY444-PHE458
A	ILE81-ALA97
A	ALA110-TYR131
A	LEU149-GLU167
A	GLY178-PHE196
A	LEU242-GLN259
A	THR286-GLN306
A	ASP357-TRP379
A	ALA421-PHE437

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site_id	SWS_FT_FI2
Number of Residues	6
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT

Chain	Residue	Details
G	ASN62-GLY68
A	VAL132-CYS148
A	SER197-ASN241
A	MET307-GLU356
A	LEU438-SER443

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P60059

Chain	Residue	Details
G	SER18
A	LEU168-SER177
A	GLY260-TYR285
A	ILE380-ALA420
A	GLU459-PHE476

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