4ZOL
Crystal Structure of Tubulin-Stathmin-TTL-Tubulysin M Complex
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000226 | biological_process | microtubule cytoskeleton organization |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0007017 | biological_process | microtubule-based process |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000226 | biological_process | microtubule cytoskeleton organization |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0007017 | biological_process | microtubule-based process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000226 | biological_process | microtubule cytoskeleton organization |
| C | 0000278 | biological_process | mitotic cell cycle |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005200 | molecular_function | structural constituent of cytoskeleton |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005856 | cellular_component | cytoskeleton |
| C | 0005874 | cellular_component | microtubule |
| C | 0007017 | biological_process | microtubule-based process |
| C | 0015630 | cellular_component | microtubule cytoskeleton |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000226 | biological_process | microtubule cytoskeleton organization |
| D | 0000278 | biological_process | mitotic cell cycle |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005200 | molecular_function | structural constituent of cytoskeleton |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0005874 | cellular_component | microtubule |
| D | 0007017 | biological_process | microtubule-based process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0031110 | biological_process | regulation of microtubule polymerization or depolymerization |
| F | 0036211 | biological_process | protein modification process |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 27 |
| 詳細 | BINDING SITE FOR RESIDUE GTP A 501 |
| 鎖名 | 残基 |
| A | GLY10 |
| A | GLY144 |
| A | THR145 |
| A | GLY146 |
| A | VAL177 |
| A | GLU183 |
| A | ASN206 |
| A | TYR224 |
| A | ASN228 |
| A | ILE231 |
| A | MG502 |
| A | GLN11 |
| A | HOH615 |
| A | HOH623 |
| A | HOH632 |
| A | HOH634 |
| A | HOH646 |
| A | HOH653 |
| A | HOH655 |
| B | LYS254 |
| A | ALA12 |
| A | GLN15 |
| A | ASP98 |
| A | ALA99 |
| A | ASN101 |
| A | SER140 |
| A | GLY143 |
| site_id | AC2 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE MG A 502 |
| 鎖名 | 残基 |
| A | GTP501 |
| A | HOH623 |
| A | HOH632 |
| A | HOH634 |
| A | HOH646 |
| B | LYS254 |
| site_id | AC3 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE CA A 503 |
| 鎖名 | 残基 |
| A | ASP39 |
| A | THR41 |
| A | GLY44 |
| A | GLU55 |
| A | HOH603 |
| site_id | AC4 |
| 残基数 | 7 |
| 詳細 | BINDING SITE FOR RESIDUE GOL A 504 |
| 鎖名 | 残基 |
| A | SER158 |
| A | GLY162 |
| A | LYS166 |
| A | GLU196 |
| A | ASP199 |
| A | HOH619 |
| E | ASP44 |
| site_id | AC5 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE GOL A 505 |
| 鎖名 | 残基 |
| A | ASN216 |
| A | PRO274 |
| A | VAL275 |
| A | ILE276 |
| A | ASN300 |
| A | HOH641 |
| site_id | AC6 |
| 残基数 | 9 |
| 詳細 | BINDING SITE FOR RESIDUE GOL A 506 |
| 鎖名 | 残基 |
| A | ALA208 |
| A | ASP211 |
| A | ILE212 |
| A | ARG215 |
| A | PRO298 |
| A | ALA299 |
| A | GLN301 |
| A | LYS304 |
| F | GOL402 |
| site_id | AC7 |
| 残基数 | 23 |
| 詳細 | BINDING SITE FOR RESIDUE GDP B 501 |
| 鎖名 | 残基 |
| B | GLY10 |
| B | GLN11 |
| B | CYS12 |
| B | GLN15 |
| B | SER140 |
| B | GLY143 |
| B | GLY144 |
| B | THR145 |
| B | GLY146 |
| B | VAL177 |
| B | SER178 |
| B | GLU183 |
| B | ASN206 |
| B | TYR224 |
| B | ASN228 |
| B | MG502 |
| B | 55Q507 |
| B | HOH601 |
| B | HOH606 |
| B | HOH607 |
| B | HOH613 |
| B | HOH620 |
| B | HOH628 |
| site_id | AC8 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE MG B 502 |
| 鎖名 | 残基 |
| B | GLU71 |
| B | GDP501 |
| B | HOH620 |
| B | HOH629 |
| B | HOH655 |
| B | HOH663 |
| site_id | AC9 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE MES B 503 |
| 鎖名 | 残基 |
| B | PHE296 |
| B | ASP297 |
| B | ALA298 |
| B | ARG308 |
| B | ASN339 |
| B | TYR342 |
| site_id | BC1 |
| 残基数 | 9 |
| 詳細 | BINDING SITE FOR RESIDUE MES B 504 |
| 鎖名 | 残基 |
| B | ASN197 |
| B | THR198 |
| B | ASP199 |
| B | ARG253 |
| B | HOH615 |
| B | ARG158 |
| B | ASP163 |
| B | ARG164 |
| B | ILE165 |
| site_id | BC2 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE GOL B 505 |
| 鎖名 | 残基 |
| B | ASP116 |
| B | ASP120 |
| C | ASP218 |
| C | GLU220 |
| site_id | BC3 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE GOL B 506 |
| 鎖名 | 残基 |
| B | ARG401 |
| C | GLU434 |
| C | GOL504 |
| site_id | BC4 |
| 残基数 | 13 |
| 詳細 | BINDING SITE FOR RESIDUE 55Q B 507 |
| 鎖名 | 残基 |
| B | GLN15 |
| B | LYS176 |
| B | ASP179 |
| B | PRO222 |
| B | THR223 |
| B | TYR224 |
| B | GLY225 |
| B | ARG278 |
| B | GDP501 |
| B | HOH609 |
| B | HOH618 |
| C | ASN329 |
| C | VAL353 |
| site_id | BC5 |
| 残基数 | 26 |
| 詳細 | BINDING SITE FOR RESIDUE GTP C 501 |
| 鎖名 | 残基 |
| C | GLY10 |
| C | GLN11 |
| C | ALA12 |
| C | GLN15 |
| C | ASP98 |
| C | ALA99 |
| C | ASN101 |
| C | SER140 |
| C | GLY143 |
| C | GLY144 |
| C | THR145 |
| C | GLY146 |
| C | VAL177 |
| C | GLU183 |
| C | ASN206 |
| C | TYR224 |
| C | ASN228 |
| C | ILE231 |
| C | MG502 |
| C | HOH606 |
| C | HOH609 |
| C | HOH627 |
| C | HOH633 |
| C | HOH662 |
| C | HOH668 |
| D | LYS254 |
| site_id | BC6 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE MG C 502 |
| 鎖名 | 残基 |
| C | GTP501 |
| C | HOH606 |
| C | HOH609 |
| C | HOH633 |
| C | HOH662 |
| site_id | BC7 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE CA C 503 |
| 鎖名 | 残基 |
| C | ASP39 |
| C | THR41 |
| C | GLY44 |
| C | GLU55 |
| C | HOH602 |
| site_id | BC8 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE GOL C 504 |
| 鎖名 | 残基 |
| B | GOL506 |
| C | ASP431 |
| C | HOH678 |
| site_id | BC9 |
| 残基数 | 23 |
| 詳細 | BINDING SITE FOR RESIDUE GDP D 501 |
| 鎖名 | 残基 |
| D | GLY10 |
| D | GLN11 |
| D | CYS12 |
| D | GLN15 |
| D | SER140 |
| D | GLY143 |
| D | GLY144 |
| D | THR145 |
| D | GLY146 |
| D | VAL177 |
| D | SER178 |
| D | GLU183 |
| D | ASN206 |
| D | TYR224 |
| D | LEU227 |
| D | ASN228 |
| D | MG502 |
| D | HOH601 |
| D | HOH607 |
| D | HOH609 |
| D | HOH620 |
| D | HOH624 |
| D | HOH629 |
| site_id | CC1 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE MG D 502 |
| 鎖名 | 残基 |
| D | GDP501 |
| D | HOH601 |
| D | HOH604 |
| D | HOH607 |
| D | HOH609 |
| D | HOH629 |
| site_id | CC2 |
| 残基数 | 10 |
| 詳細 | BINDING SITE FOR RESIDUE 55Q D 503 |
| 鎖名 | 残基 |
| D | GLN15 |
| D | PRO175 |
| D | LYS176 |
| D | VAL177 |
| D | ASP179 |
| D | PRO222 |
| D | THR223 |
| D | TYR224 |
| D | GLY225 |
| D | ARG278 |
| site_id | CC3 |
| 残基数 | 17 |
| 詳細 | BINDING SITE FOR RESIDUE ACP F 401 |
| 鎖名 | 残基 |
| F | LYS74 |
| F | ILE148 |
| F | LYS150 |
| F | GLN183 |
| F | LYS184 |
| F | TYR185 |
| F | LEU186 |
| F | LYS198 |
| F | ASP200 |
| F | ARG222 |
| F | LEU240 |
| F | THR241 |
| F | ASN242 |
| F | ASP318 |
| F | GLU331 |
| F | ASN333 |
| F | HOH501 |
| site_id | CC4 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE GOL F 402 |
| 鎖名 | 残基 |
| A | ARG215 |
| A | GOL506 |
| F | HIS306 |
| F | LEU307 |
| F | HIS308 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS00227 |
| 残基数 | 7 |
| 詳細 | TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG |
| 鎖名 | 残基 | 詳細 |
| A | GLY142-GLY148 | |
| B | GLY142-GLY148 |
| site_id | PS00228 |
| 残基数 | 4 |
| 詳細 | TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI |
| 鎖名 | 残基 | 詳細 |
| B | MET1-ILE4 |
| site_id | PS00563 |
| 残基数 | 10 |
| 詳細 | STATHMIN_1 Stathmin family signature 1. PRRRDpSLEE |
| 鎖名 | 残基 | 詳細 |
| E | PRO40-GLU49 |
| site_id | PS01041 |
| 残基数 | 10 |
| 詳細 | STATHMIN_2 Stathmin family signature 2. AEKREHEREV |
| 鎖名 | 残基 | 詳細 |
| E | ALA73-VAL82 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 1 |
| 詳細 | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| 鎖名 | 残基 | 詳細 |
| E | SER46 | |
| D | GLY144 | |
| D | THR145 | |
| D | GLY146 | |
| D | ASN206 | |
| D | ASN228 | |
| B | SER140 | |
| B | GLY144 | |
| B | THR145 | |
| B | GLY146 | |
| B | ASN206 | |
| B | ASN228 | |
| D | GLN11 | |
| D | SER140 |
| site_id | SWS_FT_FI2 |
| 残基数 | 2 |
| 詳細 | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
| 鎖名 | 残基 | 詳細 |
| B | GLU71 | |
| C | GLU71 | |
| C | SER140 | |
| C | GLY144 | |
| C | THR145 | |
| C | THR179 | |
| C | ASN206 | |
| C | ASN228 | |
| D | GLU71 | |
| A | SER140 | |
| A | GLY144 | |
| A | THR145 | |
| A | THR179 | |
| A | ASN206 | |
| A | ASN228 | |
| C | GLN11 |
| site_id | SWS_FT_FI3 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99024 |
| 鎖名 | 残基 | 詳細 |
| B | SER40 | |
| D | SER40 |
| site_id | SWS_FT_FI4 |
| 残基数 | 2 |
| 詳細 | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024 |
| 鎖名 | 残基 | 詳細 |
| B | LYS60 | |
| D | LYS60 |
| site_id | SWS_FT_FI5 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q13885 |
| 鎖名 | 残基 | 詳細 |
| B | SER174 | |
| D | SER174 | |
| C | SER48 | |
| C | SER232 |
| site_id | SWS_FT_FI6 |
| 残基数 | 4 |
| 詳細 | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07437 |
| 鎖名 | 残基 | 詳細 |
| B | THR287 | |
| B | THR292 | |
| D | THR287 | |
| D | THR292 |
| site_id | SWS_FT_FI7 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437 |
| 鎖名 | 残基 | 詳細 |
| B | ARG320 | |
| D | ARG320 |
| site_id | SWS_FT_FI8 |
| 残基数 | 2 |
| 詳細 | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0 |
| 鎖名 | 残基 | 詳細 |
| B | GLU448 | |
| D | GLU448 |
| site_id | SWS_FT_FI9 |
| 残基数 | 2 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437 |
| 鎖名 | 残基 | 詳細 |
| B | LYS60 | |
| D | LYS60 |
| site_id | SWS_FT_FI10 |
| 残基数 | 4 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 |
| 鎖名 | 残基 | 詳細 |
| A | GLU445 | |
| B | LYS326 | |
| D | LYS326 |
| site_id | SWS_FT_FI11 |
| 残基数 | 2 |
| 詳細 | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q71U36 |
| 鎖名 | 残基 | 詳細 |
| A | TYR451 | |
| C | TYR451 |
| site_id | SWS_FT_FI12 |
| 残基数 | 6 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P68363 |
| 鎖名 | 残基 | 詳細 |
| A | LYS326 | |
| A | LYS370 | |
| C | LYS326 | |
| C | LYS370 |
