4ZEL

Human dopamine beta-hydroxylase

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Functional Information from GO Data

ChainGOidnamespacecontents
A0034466cellular_componentchromaffin granule lumen
A0042584cellular_componentchromaffin granule membrane
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0016021cellular_componentintegral component of membrane
A0043231cellular_componentintracellular membrane-bounded organelle
A0016020cellular_componentmembrane
A0005815cellular_componentmicrotubule organizing center
A0034774cellular_componentsecretory granule lumen
A0030667cellular_componentsecretory granule membrane
A0030658cellular_componenttransport vesicle membrane
A0003824molecular_functioncatalytic activity
A0005507molecular_functioncopper ion binding
A0004500molecular_functiondopamine beta-monooxygenase activity
A0031418molecular_functionL-ascorbic acid binding
A0016715molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
A0048149biological_processbehavioral response to ethanol
A0001974biological_processblood vessel remodeling
A0042423biological_processcatecholamine biosynthetic process
A0007268biological_processchemical synaptic transmission
A0001816biological_processcytokine production
A0042420biological_processdopamine catabolic process
A0042596biological_processfear response
A0042593biological_processglucose homeostasis
A0042309biological_processhomoiothermy
A0002443biological_processleukocyte mediated immunity
A0050900biological_processleukocyte migration
A0007626biological_processlocomotory behavior
A0042711biological_processmaternal behavior
A0007613biological_processmemory
A0042421biological_processnorepinephrine biosynthetic process
A0006589biological_processoctopamine biosynthetic process
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0045907biological_processpositive regulation of vasoconstriction
A0042127biological_processregulation of cell proliferation
A2001236biological_processregulation of extrinsic apoptotic signaling pathway
A0001975biological_processresponse to amphetamine
A0048265biological_processresponse to pain
A0008542biological_processvisual learning
B0034466cellular_componentchromaffin granule lumen
B0042584cellular_componentchromaffin granule membrane
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0016021cellular_componentintegral component of membrane
B0043231cellular_componentintracellular membrane-bounded organelle
B0016020cellular_componentmembrane
B0005815cellular_componentmicrotubule organizing center
B0034774cellular_componentsecretory granule lumen
B0030667cellular_componentsecretory granule membrane
B0030658cellular_componenttransport vesicle membrane
B0003824molecular_functioncatalytic activity
B0005507molecular_functioncopper ion binding
B0004500molecular_functiondopamine beta-monooxygenase activity
B0031418molecular_functionL-ascorbic acid binding
B0016715molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
B0048149biological_processbehavioral response to ethanol
B0001974biological_processblood vessel remodeling
B0042423biological_processcatecholamine biosynthetic process
B0007268biological_processchemical synaptic transmission
B0001816biological_processcytokine production
B0042420biological_processdopamine catabolic process
B0042596biological_processfear response
B0042593biological_processglucose homeostasis
B0042309biological_processhomoiothermy
B0002443biological_processleukocyte mediated immunity
B0050900biological_processleukocyte migration
B0007626biological_processlocomotory behavior
B0042711biological_processmaternal behavior
B0007613biological_processmemory
B0042421biological_processnorepinephrine biosynthetic process
B0006589biological_processoctopamine biosynthetic process
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0045907biological_processpositive regulation of vasoconstriction
B0042127biological_processregulation of cell proliferation
B2001236biological_processregulation of extrinsic apoptotic signaling pathway
B0001975biological_processresponse to amphetamine
B0048265biological_processresponse to pain
B0008542biological_processvisual learning
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15binding site for residue CU A 701
ChainResidue
AHIS412
AHIS414
AMET487
AHOH805
AHOH808

AC23binding site for Mono-Saccharide NAG A 702 bound to ASN A 64
ChainResidue
ALEU47
AASN64
AVAL65

AC35binding site for Poly-Saccharide residues NAG A 705 through BMA A 707 bound to ASN A 184
ChainResidue
APHE177
AASN184
ASER186
BALA570
BVAL571

AC46binding site for Poly-Saccharide residues NAG A 703 through NAG A 704 bound to ASN A 566
ChainResidue
AVAL370
ALEU502
AHIS564
AASN566
AALA570
AARG572

AC53binding site for Mono-Saccharide NAG B 705 bound to ASN B 64
ChainResidue
BASN64
BVAL65
BGLU206

AC69binding site for Poly-Saccharide residues NAG B 701 through MAN B 704 bound to ASN B 344
ChainResidue
AARG92
AGLY185
AMET190
AARG418
AASN469
AGLU471
BASN220
BILE221
BASN344

AC77binding site for Poly-Saccharide residues NAG B 706 through BMA B 708 bound to ASN B 566
ChainResidue
BLEU502
BHIS564
BASN566
BSER569
BALA570
BVAL571
BARG572

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
NAG_4zel_A_7027N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
ALEU47-PRO48NAG: N-ACETYL-D-GLUCOSAMINE
AASN64-SER66NAG: N-ACETYL-D-GLUCOSAMINE
AHIS73NAG: N-ACETYL-D-GLUCOSAMINE
ALEU146NAG: N-ACETYL-D-GLUCOSAMINE

NAG_4zel_A_7055N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AGLU175NAG: N-ACETYL-D-GLUCOSAMINE
APHE177NAG: N-ACETYL-D-GLUCOSAMINE
AALA182NAG: N-ACETYL-D-GLUCOSAMINE
AASN184NAG: N-ACETYL-D-GLUCOSAMINE
ASER186NAG: N-ACETYL-D-GLUCOSAMINE

NAG_4zel_A_7038N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AARG296NAG: N-ACETYL-D-GLUCOSAMINE
AVAL370NAG: N-ACETYL-D-GLUCOSAMINE
ALEU502NAG: N-ACETYL-D-GLUCOSAMINE
AHIS564NAG: N-ACETYL-D-GLUCOSAMINE
AASN566NAG: N-ACETYL-D-GLUCOSAMINE
AALA570-ARG572NAG: N-ACETYL-D-GLUCOSAMINE

NAG_4zel_B_7055N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
BLEU47NAG: N-ACETYL-D-GLUCOSAMINE
BASN64-VAL65NAG: N-ACETYL-D-GLUCOSAMINE
BHIS73NAG: N-ACETYL-D-GLUCOSAMINE
BLEU146NAG: N-ACETYL-D-GLUCOSAMINE

NAG_4zel_B_7015N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
BPRO219-GLN222NAG: N-ACETYL-D-GLUCOSAMINE
BASN344NAG: N-ACETYL-D-GLUCOSAMINE

NAG_4zel_B_7068N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
BVAL370NAG: N-ACETYL-D-GLUCOSAMINE
BLEU502NAG: N-ACETYL-D-GLUCOSAMINE
BHIS564NAG: N-ACETYL-D-GLUCOSAMINE
BASN566NAG: N-ACETYL-D-GLUCOSAMINE
BSER569-ARG572NAG: N-ACETYL-D-GLUCOSAMINE

NAG_4zel_B_7072N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
BSER569-ALA570NAG: N-ACETYL-D-GLUCOSAMINE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI12{ECO:0000255}.
ChainResidueDetails
ATYR191
AHIS373

SWS_FT_FI23Copper A. {ECO:0000250}
ChainResidueDetails
AHIS223
AHIS224
AHIS294

SWS_FT_FI33Copper B. {ECO:0000250}
ChainResidueDetails
AHIS373
AHIS375
AMET448

SWS_FT_FI421Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
ChainResidueDetails
ANA*

SWS_FT_FI52{ECO:0000255}.
ChainResidueDetails
BTYR191
BHIS373

SWS_FT_FI63Copper A. {ECO:0000250}
ChainResidueDetails
BHIS223
BHIS224
BHIS294

SWS_FT_FI73Copper B. {ECO:0000250}
ChainResidueDetails
BHIS373
BHIS375
BMET448

SWS_FT_FI821Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
ChainResidueDetails
BNA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails