4XEM
Crystal Structure of wild type human AlaRS catalytic domain
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue A5A A 501 |
| Chain | Residue |
| A | ALA44 |
| A | GLU213 |
| A | ILE214 |
| A | ASN216 |
| A | VAL218 |
| A | ASP239 |
| A | THR240 |
| A | GLY241 |
| A | GLY243 |
| A | ARG246 |
| A | EDO503 |
| A | ARG77 |
| A | HOH702 |
| A | HOH711 |
| A | HOH790 |
| A | HOH953 |
| A | TYR93 |
| A | HIS94 |
| A | HIS95 |
| A | PHE98 |
| A | MET100 |
| A | TRP176 |
| A | GLU189 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | HIS336 |
| A | ALA341 |
| A | SER342 |
| A | ARG343 |
| A | LEU383 |
| A | HOH759 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | GLU189 |
| A | A5A501 |
| A | HOH837 |
| A | HOH953 |
| A | HOH1087 |
| A | HOH1088 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | MET171 |
| A | ARG224 |
| A | ASN317 |
| A | TYR322 |
| A | HOH602 |
| A | HOH629 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | PHE267 |
| A | PRO278 |
| A | TYR279 |
| A | TYR295 |
| A | HOH620 |
| A | HOH681 |
| A | HOH908 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | GLN12 |
| A | TYR25 |
| A | ARG277 |
| A | HOH607 |
| A | HOH623 |
| A | HOH666 |
| A | HOH684 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27622773, ECO:0000269|Ref.24, ECO:0007744|PDB:4XEM, ECO:0007744|PDB:4XEO, ECO:0007744|PDB:5KNN |
| Chain | Residue | Details |
| A | ARG77 | |
| A | HIS95 | |
| A | TRP176 | |
| A | ILE214 | |
| A | ASN216 | |
| A | ASP239 | |
| A | GLY243 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER3 | |
| A | SER8 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS19 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER399 |
