4TWK

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0016020	cellular_component	membrane
A	0071805	biological_process	potassium ion transmembrane transport
B	0005267	molecular_function	potassium channel activity
B	0016020	cellular_component	membrane
B	0071805	biological_process	potassium ion transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ALA62-ILE82
A	PHE172-VAL192
A	ALA224-PHE244
B	ALA62-ILE82
B	PHE172-VAL192
B	ALA224-PHE244

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site_id	SWS_FT_FI2
Number of Residues	52
Details	INTRAMEM: Pore-forming; Name=Pore-forming 1 => ECO:0000255

Chain	Residue	Details
A	GLY144-PHE170
B	GLY144-PHE170

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site_id	SWS_FT_FI3
Number of Residues	60
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	GLU193-VAL223
B	GLU193-VAL223

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site_id	SWS_FT_FI4
Number of Residues	60
Details	INTRAMEM: Pore-forming; Name=Pore-forming 2 => ECO:0000255

Chain	Residue	Details
A	GLY253-ALA283
B	GLY253-ALA283

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:4TWK

Chain	Residue	Details
A	ILE110
B	ILE110

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	PHE134
B	PHE134

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