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4PD4

Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005750cellular_componentmitochondrial respiratory chain complex III
A0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
A0006627biological_processprotein processing involved in protein targeting to mitochondrion
A0008121molecular_functionubiquinol-cytochrome-c reductase activity
A0009060biological_processaerobic respiration
A0016020cellular_componentmembrane
A0045333biological_processcellular respiration
A0046872molecular_functionmetal ion binding
A0070469cellular_componentrespirasome
A1902600biological_processproton transmembrane transport
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005750cellular_componentmitochondrial respiratory chain complex III
B0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
B0006508biological_processproteolysis
B0008121molecular_functionubiquinol-cytochrome-c reductase activity
B0009060biological_processaerobic respiration
B0016020cellular_componentmembrane
B0030061cellular_componentmitochondrial crista
B0045333biological_processcellular respiration
B0046872molecular_functionmetal ion binding
B0070469cellular_componentrespirasome
B1902600biological_processproton transmembrane transport
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0005750cellular_componentmitochondrial respiratory chain complex III
C0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
C0008121molecular_functionubiquinol-cytochrome-c reductase activity
C0009055molecular_functionelectron transfer activity
C0009060biological_processaerobic respiration
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0022904biological_processrespiratory electron transport chain
C0045275cellular_componentrespiratory chain complex III
C0045333biological_processcellular respiration
C0046872molecular_functionmetal ion binding
C0070469cellular_componentrespirasome
C1902600biological_processproton transmembrane transport
D0009055molecular_functionelectron transfer activity
D0020037molecular_functionheme binding
E0008121molecular_functionubiquinol-cytochrome-c reductase activity
E0016020cellular_componentmembrane
E0051537molecular_function2 iron, 2 sulfur cluster binding
G0005739cellular_componentmitochondrion
G0005743cellular_componentmitochondrial inner membrane
G0005750cellular_componentmitochondrial respiratory chain complex III
G0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
G0008121molecular_functionubiquinol-cytochrome-c reductase activity
G0009060biological_processaerobic respiration
G0016020cellular_componentmembrane
G0034551biological_processmitochondrial respiratory chain complex III assembly
G0045333biological_processcellular respiration
G0070469cellular_componentrespirasome
G0099617cellular_componentmatrix side of mitochondrial inner membrane
G1902600biological_processproton transmembrane transport
H0005739cellular_componentmitochondrion
H0005743cellular_componentmitochondrial inner membrane
H0005750cellular_componentmitochondrial respiratory chain complex III
H0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
H0009060biological_processaerobic respiration
H0016020cellular_componentmembrane
H0045333biological_processcellular respiration
H0070469cellular_componentrespirasome
I0005750cellular_componentmitochondrial respiratory chain complex III
I0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
J0002250biological_processadaptive immune response
J0002376biological_processimmune system process
J0003823molecular_functionantigen binding
J0016064biological_processimmunoglobulin mediated immune response
J0019814cellular_componentimmunoglobulin complex
J0072562cellular_componentblood microparticle
K0002250biological_processadaptive immune response
K0002376biological_processimmune system process
K0005615cellular_componentextracellular space
K0006955biological_processimmune response
K0019814cellular_componentimmunoglobulin complex
PDBデータベースに由来する情報
site_idAC1
残基数14
詳細binding site for residue UMQ A 501
鎖名残基
ATRP427
IASN14
IALA15
IVAL16
IPHE17
IVAL18
AASP428
ASER453
AMET454
AMET455
AARG456
A3PH502
ETYR57
ESER68

site_idAC2
残基数5
詳細binding site for residue 3PH A 502
鎖名残基
ASER450
AUMQ501
CHIS222
CILE226
ESER67

site_idAC3
残基数18
詳細binding site for residue HEM C 4001
鎖名残基
CGLN43
CILE44
CGLY47
CILE48
CMET50
CALA51
CARG79
CHIS82
CALA83
CTHR127
CALA128
CGLY131
CTYR132
CVAL135
CPHE180
CHIS183
CTYR184
CPRO187

site_idAC4
残基数18
詳細binding site for residue HEM C 4002
鎖名残基
CTRP30
CGLY33
CSER34
CLEU36
CHIS96
CMET97
CLYS99
CSER105
CLEU113
CTRP114
CGLY117
CVAL118
CILE120
CVAL194
CHIS197
CLEU201
CSER206
CSER207

site_idAC5
残基数11
詳細binding site for residue AOQ C 4003
鎖名残基
CPHE129
CMET139
CGLY143
CVAL146
CILE147
CILE269
CPRO271
CLEU275
CTYR279
CILE299
EHIS181

site_idAC6
残基数8
詳細binding site for residue 3PE C 4004
鎖名残基
CPHE3
CASN7
CTYR9
CLEU10
CTHR112
CASN115
CVAL116
CHIS204

site_idAC7
残基数11
詳細binding site for residue UQ6 C 4005
鎖名残基
CTYR16
CGLN22
CSER34
CILE48
CLEU182
CLEU185
CALA191
CLEU201
CSER206
CMET221
CASP229

site_idAC8
残基数9
詳細binding site for residue 3PH C 4006
鎖名残基
CTRP29
CMET95
CMET97
CALA98
CTYR102
CTYR103
CLEU302
CTHR317
CPHE333

site_idAC9
残基数16
詳細binding site for residue HEM D 401
鎖名残基
DALA172
DPRO175
DILE180
DARG184
DTYR190
DILE191
DLEU195
DPHE218
DMET225
DVAL228
DVAL251
DVAL100
DCYS101
DCYS104
DHIS105
DASN169

site_idAD1
残基数7
詳細binding site for residue FES E 301
鎖名残基
ECYS159
EHIS161
ELEU162
ECYS178
ECYS180
EHIS181
ESER183

site_idAD2
残基数11
詳細binding site for residue 3PH E 302
鎖名残基
CILE42
CMET237
DLEU269
DLYS272
DTHR273
DILE276
EGLY70
EALA71
ESER73
ETHR74
ETHR77

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00143
残基数23
詳細INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT
鎖名残基詳細
BGLY37-THR59

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数15
詳細TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554
鎖名残基詳細
ISER2-PHE17
CTYR103-ARG110
CGLY205-SER223
CASP309-LYS319
CILE365-LYS385

site_idSWS_FT_FI2
残基数25
詳細TRANSMEM: Helical => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554
鎖名残基詳細
IVAL18-HIS43
CGLY75-TYR102
CVAL111-VAL135
CASN173-HIS204
CTYR224-TYR246
CLYS288-THR308
CVAL320-GLY340
CTYR348-LEU364

site_idSWS_FT_FI3
残基数13
詳細TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554
鎖名残基詳細
HTYR81-VAL94
CTYR136-SER172
CSER247-ASP287
CALA341-PRO347

site_idSWS_FT_FI4
残基数4
詳細BINDING: BINDING => ECO:0000269|PubMed:10873857, ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1EZV, ECO:0007744|PDB:1KB9, ECO:0007744|PDB:1KYO, ECO:0007744|PDB:1P84, ECO:0007744|PDB:2IBZ, ECO:0007744|PDB:3CX5, ECO:0007744|PDB:3CXH, ECO:0007744|PDB:4PD4
鎖名残基詳細
ECYS159
EHIS161
ECYS178
EHIS181

site_idSWS_FT_FI5
残基数1
詳細BINDING: axial binding residue => ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1KYO
鎖名残基詳細
DHIS105
CHIS96
CHIS183
CHIS197

site_idSWS_FT_FI6
残基数1
詳細BINDING: axial binding residue => ECO:0000269|PubMed:10873857, ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1EZV, ECO:0007744|PDB:1KYO
鎖名残基詳細
DMET225

CSAにおける酵素触媒機能の情報
site_idMCSA1
残基数1
詳細M-CSA 208
鎖名残基詳細
EHIS181covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
CSER206electrostatic stabiliser, hydrogen bond donor, radical stabiliser
CLYS228electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
CASP229electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
CGLU272hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

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件を2024-03-27に公開中

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