4EPW
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation
GO（遺伝子オントロジー）由来の情報
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 23 |
| 詳細 | BINDING SITE FOR RESIDUE GDP A 201 |
| 鎖名 | 残基 |
| A | GLY12 |
| A | ASP30 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG202 |
| A | HOH315 |
| A | GLY13 |
| A | HOH326 |
| A | HOH332 |
| A | HOH380 |
| A | HOH385 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC2 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE MG A 202 |
| 鎖名 | 残基 |
| A | SER17 |
| A | GDP201 |
| A | HOH313 |
| A | HOH315 |
| A | HOH326 |
| A | HOH332 |
| site_id | AC3 |
| 残基数 | 9 |
| 詳細 | BINDING SITE FOR RESIDUE 0QV A 203 |
| 鎖名 | 残基 |
| A | LEU6 |
| A | VAL7 |
| A | GLU37 |
| A | SER39 |
| A | ASP54 |
| A | MET67 |
| A | THR74 |
| A | HOH360 |
| A | HOH456 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 4 |
| 詳細 | BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 |
| 鎖名 | 残基 | 詳細 |
| A | GLY10 | |
| A | VAL29 | |
| A | ALA59 | |
| A | ASN116 |
| site_id | SWS_FT_FI2 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17 |
| 鎖名 | 残基 | 詳細 |
| A | MET1 |
| site_id | SWS_FT_FI3 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17 |
| 鎖名 | 残基 | 詳細 |
| A | THR2 |
| site_id | SWS_FT_FI4 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838 |
| 鎖名 | 残基 | 詳細 |
| A | LYS104 |
| site_id | SWS_FT_FI5 |
| 残基数 | 1 |
| 詳細 | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486 |
| 鎖名 | 残基 | 詳細 |
| A | THR35 |
