4EPV

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation

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GO(遺伝子オントロジー)由来の情報

鎖名GO(遺伝子オントロジー)id名前空間内容
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0031234cellular_componentextrinsic component of cytoplasmic side of plasma membrane
A0005925cellular_componentfocal adhesion
A0016020cellular_componentmembrane
A0045121cellular_componentmembrane raft
A0005739cellular_componentmitochondrion
A0005886cellular_componentplasma membrane
A0019003molecular_functionGDP binding
A0019002molecular_functionGMP binding
A0005525molecular_functionGTP binding
A0003924molecular_functionGTPase activity
A0042802molecular_functionidentical protein binding
A0030275molecular_functionLRR domain binding
A0044877molecular_functionprotein-containing complex binding
A0030036biological_processactin cytoskeleton organization
A0019221biological_processcytokine-mediated signaling pathway
A0038002biological_processendocrine signaling
A0060441biological_processepithelial tube branching involved in lung morphogenesis
A0007565biological_processfemale pregnancy
A0021897biological_processforebrain astrocyte development
A0048873biological_processhomeostasis of number of cells within a tissue
A0001889biological_processliver development
A0000165biological_processMAPK cascade
A0045596biological_processnegative regulation of cell differentiation
A0043524biological_processnegative regulation of neuron apoptotic process
A0008284biological_processpositive regulation of cell proliferation
A2000774biological_processpositive regulation of cellular senescence
A0010628biological_processpositive regulation of gene expression
A0043406biological_processpositive regulation of MAP kinase activity
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051000biological_processpositive regulation of nitric-oxide synthase activity
A0001934biological_processpositive regulation of protein phosphorylation
A0035022biological_processpositive regulation of Rac protein signal transduction
A0007265biological_processRas protein signal transduction
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0031647biological_processregulation of protein stability
A0032228biological_processregulation of synaptic transmission, GABAergic
A0051384biological_processresponse to glucocorticoid
A0035900biological_processresponse to isolation stress
A0051385biological_processresponse to mineralocorticoid
A0002223biological_processstimulatory C-type lectin receptor signaling pathway
A0051146biological_processstriated muscle cell differentiation
A0008542biological_processvisual learning
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PDBデータベースに由来する情報

site_id残基数詳細
AC126BINDING SITE FOR RESIDUE GDP A 201
鎖名残基
AGLY13
AVAL14
AGLY15
ALYS16
ASER17
AALA18
APHE28
AASP30
ATYR32
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
AMG202
AHOH307
AHOH333
AHOH348
AHOH369
AHOH388
AHOH402
AHOH472
AHOH475
AHOH477

AC26BINDING SITE FOR RESIDUE MG A 202
鎖名残基
ASER17
AGDP201
AHOH307
AHOH333
AHOH341
AHOH348

AC39BINDING SITE FOR RESIDUE 0QX A 203
鎖名残基
ALEU6
AVAL7
AGLU37
ASER39
AASP54
ATYR71
AHOH398
AHOH452
AHOH468

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「HETATM」原子の座標から抽出されたリガンド結合部位

site_id残基数詳細
0QX_4epv_A_203132-(1H-INDOL-3-YLMETHYL)-1H-IMIDAZO[4,5-C]PYRIDINE binding site
鎖名残基ligand
ALYS5-VAL70QX: 2-(1H-INDOL-3-YLMETHYL)-1H-IMIDAZO[4,5-C]PYRIDINE
AGLU37-SER390QX: 2-(1H-INDOL-3-YLMETHYL)-1H-IMIDAZO[4,5-C]PYRIDINE
AASP54-LEU560QX: 2-(1H-INDOL-3-YLMETHYL)-1H-IMIDAZO[4,5-C]PYRIDINE
AGLU620QX: 2-(1H-INDOL-3-YLMETHYL)-1H-IMIDAZO[4,5-C]PYRIDINE
ATYR710QX: 2-(1H-INDOL-3-YLMETHYL)-1H-IMIDAZO[4,5-C]PYRIDINE
ATHR74-GLY750QX: 2-(1H-INDOL-3-YLMETHYL)-1H-IMIDAZO[4,5-C]PYRIDINE

GDP_4epv_A_20124GUANOSINE-5'-DIPHOSPHATE binding site
鎖名残基ligand
AALA11-ALA18GDP: GUANOSINE-5'-DIPHOSPHATE
APHE28-TYR32GDP: GUANOSINE-5'-DIPHOSPHATE
APRO34GDP: GUANOSINE-5'-DIPHOSPHATE
AASP57GDP: GUANOSINE-5'-DIPHOSPHATE
AASN116-LEU120GDP: GUANOSINE-5'-DIPHOSPHATE
ATHR144-LYS147GDP: GUANOSINE-5'-DIPHOSPHATE

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id残基数詳細
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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id残基数詳細
SWS_FT_FI117GTP.
鎖名残基詳細
AGLY11-SER18
AASP58-GLN62
AASN117-ASP120

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CSAにおける酵素触媒機能の情報

site_id残基数詳細