4DFR
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
「2DFR」から置き換えられましたGO(遺伝子オントロジー)由来の情報
鎖名 | GO(遺伝子オントロジー)id | 名前空間 | 内容 |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005542 | molecular_function | folic acid binding |
A | 0005829 | cellular_component | cytosol |
A | 0006545 | biological_process | glycine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0031427 | biological_process | response to methotrexate |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0046677 | biological_process | response to antibiotic |
A | 0050661 | molecular_function | NADP binding |
A | 0051870 | molecular_function | methotrexate binding |
A | 0051871 | molecular_function | dihydrofolic acid binding |
A | 0070401 | molecular_function | NADP+ binding |
A | 0070402 | molecular_function | NADPH binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005542 | molecular_function | folic acid binding |
B | 0005829 | cellular_component | cytosol |
B | 0006545 | biological_process | glycine biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0009410 | biological_process | response to xenobiotic stimulus |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0031427 | biological_process | response to methotrexate |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0046677 | biological_process | response to antibiotic |
B | 0050661 | molecular_function | NADP binding |
B | 0051870 | molecular_function | methotrexate binding |
B | 0051871 | molecular_function | dihydrofolic acid binding |
B | 0070401 | molecular_function | NADP+ binding |
B | 0070402 | molecular_function | NADPH binding |
PDBデータベースに由来する情報
site_id | AAB |
残基数 | 5 |
詳細 | RESIDUES INTERACTING WITH THE P-AMINO BENZOYL OF THE METHOTREXATE INHIBITOR |
鎖名 | 残基 |
A | LEU28 |
A | PHE31 |
A | ILE50 |
A | ARG52 |
A | LEU54 |
site_id | AC1 |
残基数 | 6 |
詳細 | BINDING SITE FOR RESIDUE CL A 160 |
鎖名 | 残基 |
A | GLY43 |
A | HIS45 |
A | THR46 |
A | GLY96 |
A | HOH230 |
A | HOH374 |
site_id | AC2 |
残基数 | 4 |
詳細 | BINDING SITE FOR RESIDUE CL B 160 |
鎖名 | 残基 |
B | GLY43 |
B | THR46 |
B | GLY96 |
B | HOH285 |
site_id | AC3 |
残基数 | 6 |
詳細 | BINDING SITE FOR RESIDUE CA B 161 |
鎖名 | 残基 |
A | HOH250 |
B | SER135 |
B | HOH205 |
B | HOH206 |
B | HOH207 |
B | HOH221 |
site_id | AC4 |
残基数 | 14 |
詳細 | BINDING SITE FOR RESIDUE MTX A 161 |
鎖名 | 残基 |
A | ILE5 |
A | ALA6 |
A | ASP27 |
A | PHE31 |
A | LYS32 |
A | ARG52 |
A | ARG57 |
A | ILE94 |
A | TYR100 |
A | THR113 |
A | HOH263 |
A | HOH296 |
A | HOH323 |
A | HOH328 |
site_id | AC5 |
残基数 | 17 |
詳細 | BINDING SITE FOR RESIDUE MTX B 162 |
鎖名 | 残基 |
B | ILE5 |
B | ALA6 |
B | ALA7 |
B | ASP27 |
B | LEU28 |
B | PHE31 |
B | LYS32 |
B | ILE50 |
B | ARG52 |
B | LEU54 |
B | ARG57 |
B | ILE94 |
B | TYR100 |
B | THR113 |
B | HOH202 |
B | HOH242 |
B | HOH260 |
site_id | AGL |
残基数 | 5 |
詳細 | RESIDUES INTERACTING WITH THE GLUTAMATE OF THE METHOTREXATE INHIBITOR |
鎖名 | 残基 |
A | LEU28 |
A | PHE31 |
A | LYS32 |
A | LEU54 |
A | ARG57 |
site_id | ANM |
残基数 | 1 |
詳細 | RESIDUES INTERACTING WITH THE N(10) METHYL OF THE METHOTREXATE INHIBITOR |
鎖名 | 残基 |
A | SER49 |
site_id | APT |
残基数 | 12 |
詳細 | RESIDUES INTERACTING WITH THE PTERIDINE OF THE METHOTREXATE INHIBITOR. INCLUDE WATER MOLECULES WHICH ARE BOUND EITHER TO INVARIANT SIDE CHAINS OR TO STRUCTURALLY INVARIANT MAIN CHAIN SEGMENTS. |
鎖名 | 残基 |
A | ILE5 |
A | HOH163 |
A | HOH165 |
A | HOH172 |
A | ALA6 |
A | ALA7 |
A | TRP22 |
A | ASP27 |
A | LEU28 |
A | PHE31 |
A | ILE94 |
A | THR113 |
site_id | BAB |
残基数 | 5 |
詳細 | RESIDUES INTERACTING WITH THE P-AMINO BENZOYL OF THE METHOTREXATE INHIBITOR |
鎖名 | 残基 |
B | LEU28 |
B | PHE31 |
B | ILE50 |
B | ARG52 |
B | LEU54 |
site_id | BGL |
残基数 | 5 |
詳細 | RESIDUES INTERACTING WITH THE GLUTAMATE OF THE METHOTREXATE INHIBITOR |
鎖名 | 残基 |
B | LEU28 |
B | PHE31 |
B | LYS32 |
B | LEU54 |
B | ARG57 |
site_id | BNM |
残基数 | 1 |
詳細 | RESIDUES INTERACTING WITH THE N(10) METHYL OF THE METHOTREXATE INHIBITOR |
鎖名 | 残基 |
B | SER49 |
site_id | BPT |
残基数 | 12 |
詳細 | RESIDUES INTERACTING WITH THE PTERIDINE OF THE METHOTREXATE INHIBITOR. INCLUDE WATER MOLECULES WHICH ARE BOUND EITHER TO INVARIANT SIDE CHAINS OR TO STRUCTURALLY INVARIANT MAIN CHAIN SEGMENTS. |
鎖名 | 残基 |
B | ILE5 |
B | ALA6 |
B | ALA7 |
B | TRP22 |
B | ASP27 |
B | LEU28 |
B | PHE31 |
B | ILE94 |
B | THR113 |
B | HOH170 |
B | HOH171 |
B | HOH202 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_id | PS00075 |
残基数 | 23 |
詳細 | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT |
鎖名 | 残基 | 詳細 |
A | VAL13-THR35 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
site_id | SWS_FT_FI1 |
残基数 | 10 |
詳細 | BINDING: BINDING => ECO:0000305|PubMed:9012674 |
鎖名 | 残基 | 詳細 |
B | ARG57 | |
B | THR113 | |
A | ILE5 | |
A | ASP27 | |
A | ARG52 | |
A | ARG57 | |
A | THR113 | |
B | ILE5 | |
B | ASP27 | |
B | ARG52 |
site_id | SWS_FT_FI2 |
残基数 | 12 |
詳細 | BINDING: BINDING => ECO:0000269|PubMed:19374017 |
鎖名 | 残基 | 詳細 |
A | HIS45 | |
A | SER63 | |
A | LYS76 | |
A | GLY95 | |
B | ALA7 | |
B | VAL13 | |
B | HIS45 | |
B | SER63 | |
B | LYS76 | |
B | GLY95 | |
A | ALA7 | |
A | VAL13 |