4D5N
Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0002184 | biological_process | cytoplasmic translational termination |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003747 | molecular_function | translation release factor activity |
| A | 0004045 | molecular_function | aminoacyl-tRNA hydrolase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006415 | biological_process | translational termination |
| A | 0006449 | biological_process | regulation of translational termination |
| A | 0006479 | biological_process | protein methylation |
| A | 0008079 | molecular_function | translation termination factor activity |
| A | 0016149 | molecular_function | translation release factor activity, codon specific |
| A | 0018444 | cellular_component | translation release factor complex |
| A | 0022626 | cellular_component | cytosolic ribosome |
| A | 0043022 | molecular_function | ribosome binding |
| A | 1990825 | molecular_function | sequence-specific mRNA binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: 4-hydroxylysine => ECO:0000269|PubMed:24486019 |
| Chain | Residue | Details |
| A | LYS63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N5-methylglutamine => ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20606008, ECO:0000269|PubMed:26797129 |
| Chain | Residue | Details |
| A | GLN185 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR347 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS404 | |
| A | LYS87 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:37651229 |
| Chain | Residue | Details |
| A | LYS279 |
