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4CBO

Crystal structure of Complement Factor D mutant R202A after ensemble refinement

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009617biological_processresponse to bacterium
A0016787molecular_functionhydrolase activity
A0031093cellular_componentplatelet alpha granule lumen
A0034774cellular_componentsecretory granule lumen
A0045087biological_processinnate immune response
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
B0002376biological_processimmune system process
B0004252molecular_functionserine-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006508biological_processproteolysis
B0006956biological_processcomplement activation
B0006957biological_processcomplement activation, alternative pathway
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0009617biological_processresponse to bacterium
B0016787molecular_functionhydrolase activity
B0031093cellular_componentplatelet alpha granule lumen
B0034774cellular_componentsecretory granule lumen
B0045087biological_processinnate immune response
B0070062cellular_componentextracellular exosome
B1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 1000
ChainResidue
AVAL117
APRO119
AVAL148
ALEU149
AASP150
AARG151
AMET169
ACYS170
AHOH1179

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL B 1000
ChainResidue
BVAL117
BPRO119
BVAL148
BLEU149
BASP150
BARG151
BMET169
BCYS170
BHOH1101
BHOH1103

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
ChainResidueDetails
ALEU37-CYS42

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
ChainResidueDetails
AASP177-VAL188

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS41
AASP89
ASER183
BHIS41
BASP89
BSER183

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건을2024-03-27부터공개중

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