4A4C

Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0001784	molecular_function	phosphotyrosine residue binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005509	molecular_function	calcium ion binding
A	0007166	biological_process	cell surface receptor signaling pathway
A	0023051	biological_process	regulation of signaling
A	0046872	molecular_function	metal ion binding
C	0000151	cellular_component	ubiquitin ligase complex
C	0000166	molecular_function	nucleotide binding
C	0000209	biological_process	protein polyubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0019787	molecular_function	ubiquitin-like protein transferase activity
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032991	cellular_component	protein-containing complex
C	0036211	biological_process	protein modification process
C	0051865	biological_process	protein autoubiquitination
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061631	molecular_function	ubiquitin conjugating enzyme activity
C	0070062	cellular_component	extracellular exosome
C	0070936	biological_process	protein K48-linked ubiquitination

PDBデータベースに由来する情報

site_id	AC1
残基数	4
詳細	BINDING SITE FOR RESIDUE ZN A 1436

鎖名	残基
A	CYS381
A	CYS384
A	CYS401
A	CYS404

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site_id	AC2
残基数	4
詳細	BINDING SITE FOR RESIDUE ZN A 1437

鎖名	残基
A	CYS396
A	HIS398
A	CYS416
A	CYS419

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site_id	AC3
残基数	5
詳細	BINDING SITE FOR RESIDUE CA A 1438

鎖名	残基
A	THR231
A	ASN233
A	TYR235
A	GLU240
A	ASP229

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00518
残基数	10
詳細	ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL

鎖名	残基	詳細
A	CYS396-LEU405

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site_id	PS00183
残基数	16
詳細	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL

鎖名	残基	詳細
C	TYR74-LEU89

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	1
詳細	ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133

鎖名	残基	詳細
C	CYS85

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site_id	SWS_FT_FI2
残基数	1
詳細	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332

鎖名	残基	詳細
B	PTR7
A	THR231
A	ASN233
A	TYR235
A	GLU240

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site_id	SWS_FT_FI3
残基数	1
詳細	BINDING: BINDING => ECO:0000250

鎖名	残基	詳細
A	ARG294

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site_id	SWS_FT_FI4
残基数	1
詳細	MOD_RES: Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497

鎖名	残基	詳細
A	PTR371

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