3ZTP

Orthorhombic crystal form P21212 of the Aquifex aeolicus nucleoside diphosphate kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006163	biological_process	purine nucleotide metabolic process
A	0006183	biological_process	GTP biosynthetic process
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006163	biological_process	purine nucleotide metabolic process
C	0006183	biological_process	GTP biosynthetic process
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0009117	biological_process	nucleotide metabolic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 500

Chain	Residue
A	PHE50
A	TYR51
A	TYR52
A	VAL53
A	HIS54
A	SER127
A	GLU131
A	HOH2115
A	HOH2190

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 510

Chain	Residue
A	LYS11
A	TYR51
A	ARG107
A	HIS120
A	HOH2029
A	HOH2114
A	HOH2115
A	HOH2156
A	HOH2191

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 510

Chain	Residue
C	LYS11
C	TYR51
C	LEU63
C	HIS120
C	HOH2021
C	HOH2139
C	HOH2150
C	HOH2165

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Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NaiHASDSP

Chain	Residue	Details
A	ASN117-PRO125

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Pros-phosphohistidine intermediate => ECO:0000255|HAMAP-Rule:MF_00451

Chain	Residue	Details
A	HIS120
C	HIS120

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00451

Chain	Residue	Details
A	LYS11
C	THR93
C	ARG107
C	ASN117
A	PHE59
A	ARG87
A	THR93
A	ARG107
A	ASN117
C	LYS11
C	PHE59
C	ARG87

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