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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3WA2

High resolution crystal structure of copper amine oxidase from arthrobacter globiformis

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0005507	molecular_function	copper ion binding
X	0008131	molecular_function	primary amine oxidase activity
X	0009308	biological_process	amine metabolic process
X	0016491	molecular_function	oxidoreductase activity
X	0046872	molecular_function	metal ion binding
X	0048038	molecular_function	quinone binding
X	0052595	molecular_function	aliphatic amine oxidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU X 701

Chain	Residue
X	HIS431
X	HIS433
X	HIS592
X	1PE730
X	HOH1167
X	HOH1184

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA X 702

Chain	Residue
X	ILE582
X	HOH819
X	ASP440
X	MET441
X	ASP581

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO X 703

Chain	Residue
X	TYR41
X	GLY43
X	VAL44
X	LEU45
X	ARG61
X	ARG551
X	TYR552
X	PEG722
X	HOH1238

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO X 704

Chain	Residue
X	HOH1548

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO X 705

Chain	Residue
X	TRP349
X	ILE351
X	ASN368
X	ASP393
X	VAL604
X	HOH923
X	HOH929
X	HOH1018
X	HOH1150
X	HOH1448

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO X 706

Chain	Residue
X	PRO287
X	GLY463
X	GLU465
X	HOH1355
X	HOH1549

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO X 707

Chain	Residue
X	ARG188
X	HOH1351
X	HOH1417
X	HOH1438

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO X 708

Chain	Residue
X	THR29
X	ARG532
X	ALA535
X	GLY564
X	PRO568
X	HOH956
X	HOH1423
X	HOH1506

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO X 709

Chain	Residue
X	GLN458
X	PRO462
X	GLY463
X	ASN464
X	HOH969

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO X 710

Chain	Residue
X	ASN363
X	ARG366
X	PEG720
X	HOH1387
X	HOH1701

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO X 711

Chain	Residue
X	GLY43
X	VAL44
X	PHE249
X	ASP250
X	HOH850
X	HOH1292
X	HOH1477
X	HOH1486
X	HOH1704

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO X 712

Chain	Residue
X	SER471
X	ARG472
X	HOH1226
X	HOH1504
X	HOH1518
X	HOH1609

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO X 713

Chain	Residue
X	GLU413
X	GLY415
X	HOH1115

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO X 714

Chain	Residue
X	ARG117
X	ARG188
X	VAL189
X	1PE731

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG X 715

Chain	Residue
X	ARG472
X	HOH1426
X	HOH1428
X	HOH1434
X	HOH1516

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG X 716

Chain	Residue
X	ARG485
X	GLU486
X	ASP488
X	ARG493
X	HOH1155
X	HOH1485
X	HOH1563
X	HOH1602

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PEG X 717

Chain	Residue
X	HOH942
X	HOH1219
X	HOH1311
X	PHE195
X	PRO196
X	PRO412
X	GLU413
X	PGE726
X	HOH887

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PEG X 718

Chain	Residue
X	ALA135
X	TRP168
X	SER356
X	ASP357
X	LEU358
X	TRP359
X	THR378
X	GLY380
X	PGE724
X	PGE728
X	HOH1343
X	HOH1528

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PEG X 719

Chain	Residue
X	ARG13
X	LEU14
X	ALA15
X	SER16
X	GLU19
X	ARG71
X	ASP91
X	HOH914
X	HOH1005
X	HOH1580
X	HOH1591

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG X 720

Chain	Residue
X	ALA627
X	EDO710
X	HOH1585
X	HOH1701

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PEG X 721

Chain	Residue
X	TRP349
X	TRP349
X	GLY350
X	ARG370
X	TYR389
X	GLU397
X	GLU399
X	LYS401
X	HOH889
X	HOH1534
X	HOH1584
X	HOH1695

site_id	CC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PEG X 722

Chain	Residue
X	ASP46
X	GLU253
X	ARG274
X	ASP548
X	ARG551
X	TYR552
X	EDO703
X	PEG723
X	HOH963
X	HOH1238
X	HOH1239
X	HOH1312

site_id	CC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG X 723

Chain	Residue
X	PRO47
X	ARG49
X	TYR546
X	ASP548
X	ARG551
X	PEG722
X	HOH963
X	HOH1622

site_id	CC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PGE X 724

Chain	Residue
X	VAL100
X	LEU101
X	GLU102
X	GLU104
X	PHE105
X	PRO136
X	TYR307
X	THR378
X	ILE379
X	GLY380
X	PEG718
X	PGE728
X	HOH1528
X	HOH1539

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE X 725

Chain	Residue
X	PRO424
X	ARG505
X	HOH1146
X	HOH1588
X	HOH1595

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE X 726

Chain	Residue
X	THR192
X	VAL194
X	PHE195
X	PEG717

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE X 727

Chain	Residue
X	GLU208
X	GLY211
X	ARG619

site_id	DC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PGE X 728

Chain	Residue
X	ALA135
X	LEU137
X	TRP168
X	GLY380
X	ASN381
X	TPQ382
X	PHE407
X	PEG718
X	PGE724
X	HOH1407

site_id	DC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PG4 X 729

Chain	Residue
X	ASN126
X	ASP128
X	ASP161
X	HIS170
X	VAL197
X	ALA199
X	HOH1172
X	HOH1358
X	HOH1424
X	HOH1465

site_id	DC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 1PE X 730

Chain	Residue
X	ALA402
X	HIS433
X	LEU590
X	HIS592
X	PHE593
X	ARG595
X	ASP598
X	MET602
X	PRO603
X	ASP605
X	ARG612
X	CU701
X	HOH892
X	HOH1184
X	HOH1192
X	HOH1373
X	HOH1488

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE X 731

Chain	Residue
X	VAL189
X	ASP191
X	THR192
X	EDO714
X	HOH1408

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY X 732

Chain	Residue
X	LEU156
X	ALA157
X	VAL172
X	LEU175
X	HOH840

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OXY X 733

Chain	Residue
X	GLU399
X	HIS517
X	THR606
X	VAL607
X	HOH827
X	HOH1033
X	HOH1531

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY X 734

Chain	Residue
X	ALA487
X	ARG490
X	HOH1263
X	HOH1265
X	HOH1540

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY X 735

Chain	Residue
X	THR521
X	LEU522
X	THR538
X	HOH904
X	HOH1218

Functional Information from PROSITE/UniProt

site_id	PS01164
Number of Residues	14
Details	COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. MVIsfftTigNYDY

Chain	Residue	Details
X	MET371-TYR384

site_id	PS01165
Number of Residues	14
Details	COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TfGltHFprvEDwP

Chain	Residue	Details
X	THR587-PRO600

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250\|UniProtKB:P12807

Chain	Residue	Details
X	ASP298

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with substrate; via topaquinone => ECO:0000250\|UniProtKB:P12807

Chain	Residue	Details
X	TPQ382

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P12807

Chain	Residue	Details
X	TYR296

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P46883

Chain	Residue	Details
X	ILE379

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:9405045, ECO:0007744\|PDB:1AV4, ECO:0007744\|PDB:1AVL, ECO:0007744\|PDB:1IU7, ECO:0007744\|PDB:1IVU, ECO:0007744\|PDB:1IVV, ECO:0007744\|PDB:1IVW, ECO:0007744\|PDB:1IVX, ECO:0007744\|PDB:1RJO, ECO:0007744\|PDB:1SIH, ECO:0007744\|PDB:1SII, ECO:0007744\|PDB:1UI8, ECO:0007744\|PDB:1W4N, ECO:0007744\|PDB:1W5Z, ECO:0007744\|PDB:1W6C, ECO:0007744\|PDB:1W6G, ECO:0007744\|PDB:2BT3, ECO:0007744\|PDB:2CFD, ECO:0007744\|PDB:2CFG, ECO:0007744\|PDB:2CFK, ECO:0007744\|PDB:2CFL, ECO:0007744\|PDB:2CFW, ECO:0007744\|PDB:2CG0, ECO:0007744\|PDB:2CG1, ECO:0007744\|PDB:2CWT, ECO:0007744\|PDB:2CWU, ECO:0007744\|PDB:2CWV, ECO:0007744\|PDB:2D1W, ECO:0007744\|PDB:2E2T, ECO:0007744\|PDB:2E2U, ECO:0007744\|PDB:2E2V, ECO:0007744\|PDB:2YX9, ECO:0007744\|PDB:2ZL8, ECO:0007744\|PDB:3AMO, ECO:0007744\|PDB:3KII, ECO:0007744\|PDB:3KN4, ECO:0007744\|PDB:3WA2, ECO:0007744\|PDB:3WA3

Chain	Residue	Details
X	HIS431
X	HIS433
X	HIS592

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: 2',4',5'-topaquinone => ECO:0000269\|PubMed:9405045

Chain	Residue	Details
X	TPQ382

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