3UMI

X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 601

Chain	Residue
A	CD6
A	GLU362
A	GLU365
A	HOH767

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	HOH79
A	HIS382
A	HIS432
A	HIS436

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 2

Chain	Residue
A	GLU387
A	ASN391
A	ASP429
A	HIS458
A	HOH33

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 3

Chain	Residue
A	ASP444
A	HOH732

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 4

Chain	Residue
A	GLU399
A	HIS439
A	HOH747
A	HOH748

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 5

Chain	Residue
A	HIS327
A	GLU368
A	ASP392
A	HOH711

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 6

Chain	Residue
A	GLU362
A	GLU365
A	ACT601

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site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 7

Chain	Residue
A	GLU329
A	GLN484
A	ASP488

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site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD A 8

Chain	Residue
A	HIS359

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site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 9

Chain	Residue
A	GLU321
A	ASN400

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER366

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	TYR422

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN467

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN496

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