3TZS
Crystal structure of Neutrophil gelatinase-associated lipocalin NGAL (C87S mutant) in complex with fragment 1026, phenylurea
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002376 | biological_process | immune system process |
A | 0005506 | molecular_function | iron ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006826 | biological_process | iron ion transport |
A | 0006915 | biological_process | apoptotic process |
A | 0015891 | biological_process | siderophore transport |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0035580 | cellular_component | specific granule lumen |
A | 0036094 | molecular_function | small molecule binding |
A | 0042742 | biological_process | defense response to bacterium |
A | 0042802 | molecular_function | identical protein binding |
A | 0045087 | biological_process | innate immune response |
A | 0060205 | cellular_component | cytoplasmic vesicle lumen |
A | 0070062 | cellular_component | extracellular exosome |
A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
A | 0140315 | molecular_function | iron ion sequestering activity |
A | 1903981 | molecular_function | enterobactin binding |
B | 0002376 | biological_process | immune system process |
B | 0005506 | molecular_function | iron ion binding |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0006826 | biological_process | iron ion transport |
B | 0006915 | biological_process | apoptotic process |
B | 0015891 | biological_process | siderophore transport |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0035580 | cellular_component | specific granule lumen |
B | 0036094 | molecular_function | small molecule binding |
B | 0042742 | biological_process | defense response to bacterium |
B | 0042802 | molecular_function | identical protein binding |
B | 0045087 | biological_process | innate immune response |
B | 0060205 | cellular_component | cytoplasmic vesicle lumen |
B | 0070062 | cellular_component | extracellular exosome |
B | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
B | 0140315 | molecular_function | iron ion sequestering activity |
B | 1903981 | molecular_function | enterobactin binding |
C | 0002376 | biological_process | immune system process |
C | 0005506 | molecular_function | iron ion binding |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005615 | cellular_component | extracellular space |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0006826 | biological_process | iron ion transport |
C | 0006915 | biological_process | apoptotic process |
C | 0015891 | biological_process | siderophore transport |
C | 0031410 | cellular_component | cytoplasmic vesicle |
C | 0035580 | cellular_component | specific granule lumen |
C | 0036094 | molecular_function | small molecule binding |
C | 0042742 | biological_process | defense response to bacterium |
C | 0042802 | molecular_function | identical protein binding |
C | 0045087 | biological_process | innate immune response |
C | 0060205 | cellular_component | cytoplasmic vesicle lumen |
C | 0070062 | cellular_component | extracellular exosome |
C | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
C | 0140315 | molecular_function | iron ion sequestering activity |
C | 1903981 | molecular_function | enterobactin binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PHU A 201 |
Chain | Residue |
A | ILE41 |
A | PHE123 |
A | LYS125 |
A | TYR132 |
A | SO4184 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 206 |
Chain | Residue |
C | HOH232 |
A | LYS75 |
C | ILE8 |
C | ASN164 |
C | HIS165 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 183 |
Chain | Residue |
A | THR54 |
A | ARG81 |
A | TYR138 |
A | HOH248 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 184 |
Chain | Residue |
A | TRP79 |
A | ARG81 |
A | TYR106 |
A | LYS125 |
A | LYS134 |
A | PHU201 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PHU A 185 |
Chain | Residue |
A | GLN23 |
A | GLN26 |
B | ASN25 |
B | GLN26 |
B | HOH215 |
C | GLN26 |
C | SO4188 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 186 |
Chain | Residue |
A | THR93 |
A | LEU94 |
A | SER105 |
A | TYR106 |
B | GLY86 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PHU B 201 |
Chain | Residue |
B | ILE41 |
B | PHE123 |
B | TYR132 |
B | LYS134 |
B | SO4184 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 206 |
Chain | Residue |
B | ILE8 |
B | LYS75 |
B | ASN164 |
B | HIS165 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL B 183 |
Chain | Residue |
B | TYR52 |
B | THR54 |
B | LYS134 |
B | TYR138 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 184 |
Chain | Residue |
B | ARG81 |
B | TYR106 |
B | LYS134 |
B | HOH190 |
B | PHU201 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PHU C 201 |
Chain | Residue |
C | ILE41 |
C | PHE123 |
C | LYS125 |
C | TYR132 |
C | SO4185 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 206 |
Chain | Residue |
A | ASN164 |
A | HIS165 |
A | HOH221 |
C | LYS75 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO C 183 |
Chain | Residue |
C | THR93 |
C | LEU94 |
C | TYR106 |
site_id | BC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL C 184 |
Chain | Residue |
C | THR54 |
C | TYR138 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 185 |
Chain | Residue |
C | TRP79 |
C | ARG81 |
C | TYR106 |
C | LYS134 |
C | PHU201 |
site_id | BC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PHU C 186 |
Chain | Residue |
B | GLN23 |
B | GLN26 |
C | GLN26 |
C | TYR115 |
C | ASN116 |
C | ARG140 |
C | HOH250 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 187 |
Chain | Residue |
A | ILE55 |
A | CYS175 |
C | ASN129 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 188 |
Chain | Residue |
A | PHU185 |
B | ASN25 |
B | HOH209 |
C | ASN25 |
C | GLN26 |
C | HOH250 |
Functional Information from PROSITE/UniProt
site_id | PS00213 |
Number of Residues | 14 |
Details | LIPOCALIN Lipocalin signature. NFQdnQFQGKWYVV |
Chain | Residue | Details |
A | ASN21-VAL34 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U |
Chain | Residue | Details |
A | TYR52 | |
B | TYR52 | |
C | TYR52 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0007744|PDB:3CMP |
Chain | Residue | Details |
A | TYR106 | |
A | LYS134 | |
B | TYR106 | |
B | LYS134 | |
C | TYR106 | |
C | LYS134 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U |
Chain | Residue | Details |
B | TYR138 | |
C | LYS125 | |
C | TYR138 | |
A | LYS125 | |
A | TYR138 | |
B | LYS125 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:7683678 |
Chain | Residue | Details |
A | GLN1 | |
B | GLN1 | |
C | GLN1 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10684642, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7683678, ECO:0007744|PDB:1DFV, ECO:0007744|PDB:1QQS |
Chain | Residue | Details |
A | ASN65 | |
B | ASN65 | |
C | ASN65 |