3R45
Structure of a CENP-A-Histone H4 Heterodimer in complex with chaperone HJURP
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0000132 | biological_process | establishment of mitotic spindle orientation |
| A | 0000281 | biological_process | mitotic cytokinesis |
| A | 0000775 | cellular_component | chromosome, centromeric region |
| A | 0000779 | cellular_component | condensed chromosome, centromeric region |
| A | 0000786 | cellular_component | nucleosome |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005721 | cellular_component | pericentric heterochromatin |
| A | 0005829 | cellular_component | cytosol |
| A | 0007049 | biological_process | cell cycle |
| A | 0030527 | molecular_function | structural constituent of chromatin |
| A | 0034080 | biological_process | CENP-A containing chromatin assembly |
| A | 0043229 | cellular_component | intracellular organelle |
| A | 0043505 | cellular_component | CENP-A containing nucleosome |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0051301 | biological_process | cell division |
| A | 0051382 | biological_process | kinetochore assembly |
| A | 0061638 | cellular_component | CENP-A containing chromatin |
| A | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| A | 0071459 | biological_process | protein localization to chromosome, centromeric region |
| B | 0000781 | cellular_component | chromosome, telomeric region |
| B | 0000786 | cellular_component | nucleosome |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0006325 | biological_process | chromatin organization |
| B | 0006334 | biological_process | nucleosome assembly |
| B | 0016020 | cellular_component | membrane |
| B | 0030527 | molecular_function | structural constituent of chromatin |
| B | 0032200 | biological_process | telomere organization |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0043505 | cellular_component | CENP-A containing nucleosome |
| B | 0045653 | biological_process | negative regulation of megakaryocyte differentiation |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0061644 | biological_process | protein localization to CENP-A containing chromatin |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0005634 | cellular_component | nucleus |
| C | 0042393 | molecular_function | histone binding |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A 141 |
| 鎖名 | 残基 |
| A | ARG63 |
| A | LYS64 |
| A | HOH150 |
| C | GLY67 |
| site_id | AC2 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A 142 |
| 鎖名 | 残基 |
| A | ARG69 |
| A | ARG72 |
| C | LYS72 |
| C | ARG74 |
| site_id | AC3 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A 143 |
| 鎖名 | 残基 |
| A | LYS124 |
| A | HOH153 |
| A | ARG118 |
| site_id | AC4 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A 144 |
| 鎖名 | 残基 |
| A | ARG118 |
| A | ARG118 |
| A | VAL119 |
| A | VAL119 |
| A | THR120 |
| A | THR120 |
| site_id | AC5 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE GOL A 145 |
| 鎖名 | 残基 |
| A | HOH155 |
| A | HOH155 |
| A | HOH156 |
| site_id | AC6 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 B 103 |
| 鎖名 | 残基 |
| A | ARG63 |
| B | THR30 |
| B | PRO32 |
| B | ARG36 |
| site_id | AC7 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 B 104 |
| 鎖名 | 残基 |
| B | LYS77 |
| B | ARG78 |
| B | LYS79 |
| B | THR80 |
| C | SO485 |
| site_id | AC8 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 B 105 |
| 鎖名 | 残基 |
| B | LYS31 |
| B | ARG35 |
| B | SO4106 |
| site_id | AC9 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 B 106 |
| 鎖名 | 残基 |
| B | THR30 |
| B | LYS31 |
| B | PRO32 |
| B | ARG55 |
| B | SO4105 |
| site_id | BC1 |
| 残基数 | 2 |
| 詳細 | BINDING SITE FOR RESIDUE GOL B 107 |
| 鎖名 | 残基 |
| B | ARG39 |
| B | ARG45 |
| site_id | BC2 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 C 81 |
| 鎖名 | 残基 |
| C | ARG23 |
| C | ARG27 |
| C | ARG31 |
| C | ARG35 |
| site_id | BC3 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 C 82 |
| 鎖名 | 残基 |
| B | THR71 |
| C | GLN42 |
| C | PRO43 |
| C | PHE44 |
| C | GLU45 |
| site_id | BC4 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 C 83 |
| 鎖名 | 残基 |
| C | ARG64 |
| C | ARG69 |
| C | LEU70 |
| site_id | BC5 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 C 84 |
| 鎖名 | 残基 |
| C | ASP15 |
| C | HOH95 |
| C | HOH98 |
| site_id | BC6 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 C 85 |
| 鎖名 | 残基 |
| A | GLN87 |
| B | LYS77 |
| B | SO4104 |
| C | GLU45 |
| C | HOH87 |
| site_id | BC7 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE GOL C 86 |
| 鎖名 | 残基 |
| C | ALA24 |
| C | ARG27 |
| C | ARG28 |
| C | ARG31 |
| C | ARG35 |
| C | HOH97 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 4 |
| 詳細 | DNA_BIND: |
| 鎖名 | 残基 | 詳細 |
| B | LYS16-LYS20 |
| site_id | SWS_FT_FI2 |
| 残基数 | 1 |
| 詳細 | MOD_RES: Phosphoserine => ECO:0000269|PubMed:17967882 |
| 鎖名 | 残基 | 詳細 |
| B | SER1 |
| site_id | SWS_FT_FI3 |
| 残基数 | 1 |
| 詳細 | MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250|UniProtKB:P62806 |
| 鎖名 | 残基 | 詳細 |
| B | ARG3 | |
| A | SER19 |
| site_id | SWS_FT_FI4 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732 |
| 鎖名 | 残基 | 詳細 |
| B | LYS5 |
| site_id | SWS_FT_FI5 |
| 残基数 | 3 |
| 詳細 | MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393 |
| 鎖名 | 残基 | 詳細 |
| B | LYS8 | |
| B | LYS16 | |
| B | LYS44 |
| site_id | SWS_FT_FI6 |
| 残基数 | 4 |
| 詳細 | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| 鎖名 | 残基 | 詳細 |
| B | LYS12 | |
| B | LYS31 | |
| B | LYS77 | |
| B | LYS91 |
| site_id | SWS_FT_FI7 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793 |
| 鎖名 | 残基 | 詳細 |
| B | LYS20 |
| site_id | SWS_FT_FI8 |
| 残基数 | 1 |
| 詳細 | MOD_RES: Phosphoserine; by PAK2 => ECO:0000269|PubMed:21724829, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| 鎖名 | 残基 | 詳細 |
| B | SER47 |
| site_id | SWS_FT_FI9 |
| 残基数 | 1 |
| 詳細 | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:20068231 |
| 鎖名 | 残基 | 詳細 |
| B | TYR51 |
| site_id | SWS_FT_FI10 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297 |
| 鎖名 | 残基 | 詳細 |
| B | LYS59 |
| site_id | SWS_FT_FI11 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62806 |
| 鎖名 | 残基 | 詳細 |
| B | LYS79 |
| site_id | SWS_FT_FI12 |
| 残基数 | 1 |
| 詳細 | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62806 |
| 鎖名 | 残基 | 詳細 |
| B | THR80 |
| site_id | SWS_FT_FI13 |
| 残基数 | 1 |
| 詳細 | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
| 鎖名 | 残基 | 詳細 |
| B | TYR88 |
| site_id | SWS_FT_FI14 |
| 残基数 | 1 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447 |
| 鎖名 | 残基 | 詳細 |
| B | LYS12 |
| site_id | SWS_FT_FI15 |
| 残基数 | 2 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:19818714 |
| 鎖名 | 残基 | 詳細 |
| B | LYS91 |
| site_id | SWS_FT_FI16 |
| 残基数 | 3 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
| 鎖名 | 残基 | 詳細 |
| B | LYS20 | |
| B | LYS59 | |
| B | LYS79 |
| site_id | SWS_FT_FI17 |
| 残基数 | 1 |
| 詳細 | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000269|PubMed:30886146 |
| 鎖名 | 残基 | 詳細 |
| B | LYS31 |
