3P87

Structure of human PCNA bound to RNASEH2B PIP box peptide

?

Functional Information from GO Data

ChainGOidnamespacecontents
A0005813cellular_componentcentrosome
A0000785cellular_componentchromatin
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0070062cellular_componentextracellular exosome
A0016604cellular_componentnuclear body
A0000784cellular_componentnuclear chromosome, telomeric region
A0005652cellular_componentnuclear lamina
A0043596cellular_componentnuclear replication fork
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0043626cellular_componentPCNA complex
A0070557cellular_componentPCNA-p21 complex
A0005657cellular_componentreplication fork
A0030894cellular_componentreplisome
A0003682molecular_functionchromatin binding
A0003684molecular_functiondamaged DNA binding
A0032139molecular_functiondinucleotide insertion or deletion binding
A0070182molecular_functionDNA polymerase binding
A0030337molecular_functionDNA polymerase processivity factor activity
A0019899molecular_functionenzyme binding
A0030331molecular_functionestrogen receptor binding
A0035035molecular_functionhistone acetyltransferase binding
A0042802molecular_functionidentical protein binding
A0032405molecular_functionMutLalpha complex binding
A0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
A0030971molecular_functionreceptor tyrosine kinase binding
A0006287biological_processbase-excision repair, gap-filling
A0070301biological_processcellular response to hydrogen peroxide
A0034644biological_processcellular response to UV
A0071466biological_processcellular response to xenobiotic stimulus
A0042769biological_processDNA damage response, detection of DNA damage
A0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
A0030855biological_processepithelial cell differentiation
A0070987biological_processerror-free translesion synthesis
A0042276biological_processerror-prone translesion synthesis
A0044849biological_processestrous cycle
A0007507biological_processheart development
A0006272biological_processleading strand elongation
A0097421biological_processliver regeneration
A0006298biological_processmismatch repair
A1902990biological_processmitotic telomere maintenance via semi-conservative replication
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0006297biological_processnucleotide-excision repair, DNA gap filling
A0033683biological_processnucleotide-excision repair, DNA incision
A0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
A0032077biological_processpositive regulation of deoxyribonuclease activity
A0045739biological_processpositive regulation of DNA repair
A0045740biological_processpositive regulation of DNA replication
A0016567biological_processprotein ubiquitination
A0000083biological_processregulation of transcription involved in G1/S transition of mitotic cell cycle
A0031297biological_processreplication fork processing
A0046686biological_processresponse to cadmium ion
A0071548biological_processresponse to dexamethasone
A0032355biological_processresponse to estradiol
A1902065biological_processresponse to L-glutamate
A0000723biological_processtelomere maintenance
A0032201biological_processtelomere maintenance via semi-conservative replication
A0006283biological_processtranscription-coupled nucleotide-excision repair
A0019985biological_processtranslesion synthesis
A0016032biological_processviral process
B0005813cellular_componentcentrosome
B0000785cellular_componentchromatin
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0070062cellular_componentextracellular exosome
B0016604cellular_componentnuclear body
B0000784cellular_componentnuclear chromosome, telomeric region
B0005652cellular_componentnuclear lamina
B0043596cellular_componentnuclear replication fork
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0043626cellular_componentPCNA complex
B0070557cellular_componentPCNA-p21 complex
B0005657cellular_componentreplication fork
B0030894cellular_componentreplisome
B0003682molecular_functionchromatin binding
B0003684molecular_functiondamaged DNA binding
B0032139molecular_functiondinucleotide insertion or deletion binding
B0070182molecular_functionDNA polymerase binding
B0030337molecular_functionDNA polymerase processivity factor activity
B0019899molecular_functionenzyme binding
B0030331molecular_functionestrogen receptor binding
B0035035molecular_functionhistone acetyltransferase binding
B0042802molecular_functionidentical protein binding
B0032405molecular_functionMutLalpha complex binding
B0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
B0030971molecular_functionreceptor tyrosine kinase binding
B0006287biological_processbase-excision repair, gap-filling
B0070301biological_processcellular response to hydrogen peroxide
B0034644biological_processcellular response to UV
B0071466biological_processcellular response to xenobiotic stimulus
B0042769biological_processDNA damage response, detection of DNA damage
B0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
B0030855biological_processepithelial cell differentiation
B0070987biological_processerror-free translesion synthesis
B0042276biological_processerror-prone translesion synthesis
B0044849biological_processestrous cycle
B0007507biological_processheart development
B0006272biological_processleading strand elongation
B0097421biological_processliver regeneration
B0006298biological_processmismatch repair
B1902990biological_processmitotic telomere maintenance via semi-conservative replication
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0006297biological_processnucleotide-excision repair, DNA gap filling
B0033683biological_processnucleotide-excision repair, DNA incision
B0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
B0032077biological_processpositive regulation of deoxyribonuclease activity
B0045739biological_processpositive regulation of DNA repair
B0045740biological_processpositive regulation of DNA replication
B0016567biological_processprotein ubiquitination
B0000083biological_processregulation of transcription involved in G1/S transition of mitotic cell cycle
B0031297biological_processreplication fork processing
B0046686biological_processresponse to cadmium ion
B0071548biological_processresponse to dexamethasone
B0032355biological_processresponse to estradiol
B1902065biological_processresponse to L-glutamate
B0000723biological_processtelomere maintenance
B0032201biological_processtelomere maintenance via semi-conservative replication
B0006283biological_processtranscription-coupled nucleotide-excision repair
B0019985biological_processtranslesion synthesis
B0016032biological_processviral process
C0005813cellular_componentcentrosome
C0000785cellular_componentchromatin
C0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
C0070062cellular_componentextracellular exosome
C0016604cellular_componentnuclear body
C0000784cellular_componentnuclear chromosome, telomeric region
C0005652cellular_componentnuclear lamina
C0043596cellular_componentnuclear replication fork
C0005654cellular_componentnucleoplasm
C0005634cellular_componentnucleus
C0043626cellular_componentPCNA complex
C0070557cellular_componentPCNA-p21 complex
C0005657cellular_componentreplication fork
C0030894cellular_componentreplisome
C0003682molecular_functionchromatin binding
C0003684molecular_functiondamaged DNA binding
C0032139molecular_functiondinucleotide insertion or deletion binding
C0070182molecular_functionDNA polymerase binding
C0030337molecular_functionDNA polymerase processivity factor activity
C0019899molecular_functionenzyme binding
C0030331molecular_functionestrogen receptor binding
C0035035molecular_functionhistone acetyltransferase binding
C0042802molecular_functionidentical protein binding
C0032405molecular_functionMutLalpha complex binding
C0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
C0030971molecular_functionreceptor tyrosine kinase binding
C0006287biological_processbase-excision repair, gap-filling
C0070301biological_processcellular response to hydrogen peroxide
C0034644biological_processcellular response to UV
C0071466biological_processcellular response to xenobiotic stimulus
C0042769biological_processDNA damage response, detection of DNA damage
C0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
C0030855biological_processepithelial cell differentiation
C0070987biological_processerror-free translesion synthesis
C0042276biological_processerror-prone translesion synthesis
C0044849biological_processestrous cycle
C0007507biological_processheart development
C0006272biological_processleading strand elongation
C0097421biological_processliver regeneration
C0006298biological_processmismatch repair
C1902990biological_processmitotic telomere maintenance via semi-conservative replication
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0006297biological_processnucleotide-excision repair, DNA gap filling
C0033683biological_processnucleotide-excision repair, DNA incision
C0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
C0032077biological_processpositive regulation of deoxyribonuclease activity
C0045739biological_processpositive regulation of DNA repair
C0045740biological_processpositive regulation of DNA replication
C0016567biological_processprotein ubiquitination
C0000083biological_processregulation of transcription involved in G1/S transition of mitotic cell cycle
C0031297biological_processreplication fork processing
C0046686biological_processresponse to cadmium ion
C0071548biological_processresponse to dexamethasone
C0032355biological_processresponse to estradiol
C1902065biological_processresponse to L-glutamate
C0000723biological_processtelomere maintenance
C0032201biological_processtelomere maintenance via semi-conservative replication
C0006283biological_processtranscription-coupled nucleotide-excision repair
C0019985biological_processtranslesion synthesis
C0016032biological_processviral process
D0005813cellular_componentcentrosome
D0000785cellular_componentchromatin
D0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
D0070062cellular_componentextracellular exosome
D0016604cellular_componentnuclear body
D0000784cellular_componentnuclear chromosome, telomeric region
D0005652cellular_componentnuclear lamina
D0043596cellular_componentnuclear replication fork
D0005654cellular_componentnucleoplasm
D0005634cellular_componentnucleus
D0043626cellular_componentPCNA complex
D0070557cellular_componentPCNA-p21 complex
D0005657cellular_componentreplication fork
D0030894cellular_componentreplisome
D0003682molecular_functionchromatin binding
D0003684molecular_functiondamaged DNA binding
D0032139molecular_functiondinucleotide insertion or deletion binding
D0070182molecular_functionDNA polymerase binding
D0030337molecular_functionDNA polymerase processivity factor activity
D0019899molecular_functionenzyme binding
D0030331molecular_functionestrogen receptor binding
D0035035molecular_functionhistone acetyltransferase binding
D0042802molecular_functionidentical protein binding
D0032405molecular_functionMutLalpha complex binding
D0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
D0030971molecular_functionreceptor tyrosine kinase binding
D0006287biological_processbase-excision repair, gap-filling
D0070301biological_processcellular response to hydrogen peroxide
D0034644biological_processcellular response to UV
D0071466biological_processcellular response to xenobiotic stimulus
D0042769biological_processDNA damage response, detection of DNA damage
D0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
D0030855biological_processepithelial cell differentiation
D0070987biological_processerror-free translesion synthesis
D0042276biological_processerror-prone translesion synthesis
D0044849biological_processestrous cycle
D0007507biological_processheart development
D0006272biological_processleading strand elongation
D0097421biological_processliver regeneration
D0006298biological_processmismatch repair
D1902990biological_processmitotic telomere maintenance via semi-conservative replication
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0006297biological_processnucleotide-excision repair, DNA gap filling
D0033683biological_processnucleotide-excision repair, DNA incision
D0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
D0032077biological_processpositive regulation of deoxyribonuclease activity
D0045739biological_processpositive regulation of DNA repair
D0045740biological_processpositive regulation of DNA replication
D0016567biological_processprotein ubiquitination
D0000083biological_processregulation of transcription involved in G1/S transition of mitotic cell cycle
D0031297biological_processreplication fork processing
D0046686biological_processresponse to cadmium ion
D0071548biological_processresponse to dexamethasone
D0032355biological_processresponse to estradiol
D1902065biological_processresponse to L-glutamate
D0000723biological_processtelomere maintenance
D0032201biological_processtelomere maintenance via semi-conservative replication
D0006283biological_processtranscription-coupled nucleotide-excision repair
D0019985biological_processtranslesion synthesis
D0016032biological_processviral process
E0005813cellular_componentcentrosome
E0000785cellular_componentchromatin
E0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
E0070062cellular_componentextracellular exosome
E0016604cellular_componentnuclear body
E0000784cellular_componentnuclear chromosome, telomeric region
E0005652cellular_componentnuclear lamina
E0043596cellular_componentnuclear replication fork
E0005654cellular_componentnucleoplasm
E0005634cellular_componentnucleus
E0043626cellular_componentPCNA complex
E0070557cellular_componentPCNA-p21 complex
E0005657cellular_componentreplication fork
E0030894cellular_componentreplisome
E0003682molecular_functionchromatin binding
E0003684molecular_functiondamaged DNA binding
E0032139molecular_functiondinucleotide insertion or deletion binding
E0070182molecular_functionDNA polymerase binding
E0030337molecular_functionDNA polymerase processivity factor activity
E0019899molecular_functionenzyme binding
E0030331molecular_functionestrogen receptor binding
E0035035molecular_functionhistone acetyltransferase binding
E0042802molecular_functionidentical protein binding
E0032405molecular_functionMutLalpha complex binding
E0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
E0030971molecular_functionreceptor tyrosine kinase binding
E0006287biological_processbase-excision repair, gap-filling
E0070301biological_processcellular response to hydrogen peroxide
E0034644biological_processcellular response to UV
E0071466biological_processcellular response to xenobiotic stimulus
E0042769biological_processDNA damage response, detection of DNA damage
E0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
E0030855biological_processepithelial cell differentiation
E0070987biological_processerror-free translesion synthesis
E0042276biological_processerror-prone translesion synthesis
E0044849biological_processestrous cycle
E0007507biological_processheart development
E0006272biological_processleading strand elongation
E0097421biological_processliver regeneration
E0006298biological_processmismatch repair
E1902990biological_processmitotic telomere maintenance via semi-conservative replication
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0006297biological_processnucleotide-excision repair, DNA gap filling
E0033683biological_processnucleotide-excision repair, DNA incision
E0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
E0032077biological_processpositive regulation of deoxyribonuclease activity
E0045739biological_processpositive regulation of DNA repair
E0045740biological_processpositive regulation of DNA replication
E0016567biological_processprotein ubiquitination
E0000083biological_processregulation of transcription involved in G1/S transition of mitotic cell cycle
E0031297biological_processreplication fork processing
E0046686biological_processresponse to cadmium ion
E0071548biological_processresponse to dexamethasone
E0032355biological_processresponse to estradiol
E1902065biological_processresponse to L-glutamate
E0000723biological_processtelomere maintenance
E0032201biological_processtelomere maintenance via semi-conservative replication
E0006283biological_processtranscription-coupled nucleotide-excision repair
E0019985biological_processtranslesion synthesis
E0016032biological_processviral process
F0005813cellular_componentcentrosome
F0000785cellular_componentchromatin
F0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
F0070062cellular_componentextracellular exosome
F0016604cellular_componentnuclear body
F0000784cellular_componentnuclear chromosome, telomeric region
F0005652cellular_componentnuclear lamina
F0043596cellular_componentnuclear replication fork
F0005654cellular_componentnucleoplasm
F0005634cellular_componentnucleus
F0043626cellular_componentPCNA complex
F0070557cellular_componentPCNA-p21 complex
F0005657cellular_componentreplication fork
F0030894cellular_componentreplisome
F0003682molecular_functionchromatin binding
F0003684molecular_functiondamaged DNA binding
F0032139molecular_functiondinucleotide insertion or deletion binding
F0070182molecular_functionDNA polymerase binding
F0030337molecular_functionDNA polymerase processivity factor activity
F0019899molecular_functionenzyme binding
F0030331molecular_functionestrogen receptor binding
F0035035molecular_functionhistone acetyltransferase binding
F0042802molecular_functionidentical protein binding
F0032405molecular_functionMutLalpha complex binding
F0000701molecular_functionpurine-specific mismatch base pair DNA N-glycosylase activity
F0030971molecular_functionreceptor tyrosine kinase binding
F0006287biological_processbase-excision repair, gap-filling
F0070301biological_processcellular response to hydrogen peroxide
F0034644biological_processcellular response to UV
F0071466biological_processcellular response to xenobiotic stimulus
F0042769biological_processDNA damage response, detection of DNA damage
F0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
F0030855biological_processepithelial cell differentiation
F0070987biological_processerror-free translesion synthesis
F0042276biological_processerror-prone translesion synthesis
F0044849biological_processestrous cycle
F0007507biological_processheart development
F0006272biological_processleading strand elongation
F0097421biological_processliver regeneration
F0006298biological_processmismatch repair
F1902990biological_processmitotic telomere maintenance via semi-conservative replication
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0006297biological_processnucleotide-excision repair, DNA gap filling
F0033683biological_processnucleotide-excision repair, DNA incision
F0006296biological_processnucleotide-excision repair, DNA incision, 5'-to lesion
F0032077biological_processpositive regulation of deoxyribonuclease activity
F0045739biological_processpositive regulation of DNA repair
F0045740biological_processpositive regulation of DNA replication
F0016567biological_processprotein ubiquitination
F0000083biological_processregulation of transcription involved in G1/S transition of mitotic cell cycle
F0031297biological_processreplication fork processing
F0046686biological_processresponse to cadmium ion
F0071548biological_processresponse to dexamethasone
F0032355biological_processresponse to estradiol
F1902065biological_processresponse to L-glutamate
F0000723biological_processtelomere maintenance
F0032201biological_processtelomere maintenance via semi-conservative replication
F0006283biological_processtranscription-coupled nucleotide-excision repair
F0019985biological_processtranslesion synthesis
F0016032biological_processviral process
G0005654cellular_componentnucleoplasm
G0005634cellular_componentnucleus
G0032299cellular_componentribonuclease H2 complex
G0004523molecular_functionRNA-DNA hybrid ribonuclease activity
G0001701biological_processin utero embryonic development
G0010629biological_processnegative regulation of gene expression
G0048146biological_processpositive regulation of fibroblast proliferation
G2000001biological_processregulation of DNA damage checkpoint
G0010389biological_processregulation of G2/M transition of mitotic cell cycle
G0009259biological_processribonucleotide metabolic process
G0006401biological_processRNA catabolic process
H0005654cellular_componentnucleoplasm
H0005634cellular_componentnucleus
H0032299cellular_componentribonuclease H2 complex
H0004523molecular_functionRNA-DNA hybrid ribonuclease activity
H0001701biological_processin utero embryonic development
H0010629biological_processnegative regulation of gene expression
H0048146biological_processpositive regulation of fibroblast proliferation
H2000001biological_processregulation of DNA damage checkpoint
H0010389biological_processregulation of G2/M transition of mitotic cell cycle
H0009259biological_processribonucleotide metabolic process
H0006401biological_processRNA catabolic process
I0005654cellular_componentnucleoplasm
I0005634cellular_componentnucleus
I0032299cellular_componentribonuclease H2 complex
I0004523molecular_functionRNA-DNA hybrid ribonuclease activity
I0001701biological_processin utero embryonic development
I0010629biological_processnegative regulation of gene expression
I0048146biological_processpositive regulation of fibroblast proliferation
I2000001biological_processregulation of DNA damage checkpoint
I0010389biological_processregulation of G2/M transition of mitotic cell cycle
I0009259biological_processribonucleotide metabolic process
I0006401biological_processRNA catabolic process
J0005654cellular_componentnucleoplasm
J0005634cellular_componentnucleus
J0032299cellular_componentribonuclease H2 complex
J0004523molecular_functionRNA-DNA hybrid ribonuclease activity
J0001701biological_processin utero embryonic development
J0010629biological_processnegative regulation of gene expression
J0048146biological_processpositive regulation of fibroblast proliferation
J2000001biological_processregulation of DNA damage checkpoint
J0010389biological_processregulation of G2/M transition of mitotic cell cycle
J0009259biological_processribonucleotide metabolic process
J0006401biological_processRNA catabolic process
K0005654cellular_componentnucleoplasm
K0005634cellular_componentnucleus
K0032299cellular_componentribonuclease H2 complex
K0004523molecular_functionRNA-DNA hybrid ribonuclease activity
K0001701biological_processin utero embryonic development
K0010629biological_processnegative regulation of gene expression
K0048146biological_processpositive regulation of fibroblast proliferation
K2000001biological_processregulation of DNA damage checkpoint
K0010389biological_processregulation of G2/M transition of mitotic cell cycle
K0009259biological_processribonucleotide metabolic process
K0006401biological_processRNA catabolic process
L0005654cellular_componentnucleoplasm
L0005634cellular_componentnucleus
L0032299cellular_componentribonuclease H2 complex
L0004523molecular_functionRNA-DNA hybrid ribonuclease activity
L0001701biological_processin utero embryonic development
L0010629biological_processnegative regulation of gene expression
L0048146biological_processpositive regulation of fibroblast proliferation
L2000001biological_processregulation of DNA damage checkpoint
L0010389biological_processregulation of G2/M transition of mitotic cell cycle
L0009259biological_processribonucleotide metabolic process
L0006401biological_processRNA catabolic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI120Potential.
ChainResidueDetails
AARG61-LYS80

SWS_FT_FI220Potential.
ChainResidueDetails
BARG61-LYS80

SWS_FT_FI320Potential.
ChainResidueDetails
CARG61-LYS80

SWS_FT_FI420Potential.
ChainResidueDetails
DARG61-LYS80

SWS_FT_FI520Potential.
ChainResidueDetails
EARG61-LYS80

SWS_FT_FI620Potential.
ChainResidueDetails
FARG61-LYS80

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Catalytic Information from CSA

site_idNumber of ResiduesDetails