3P56

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006298	biological_process	mismatch repair
A	0006401	biological_process	RNA catabolic process
A	0016070	biological_process	RNA metabolic process
A	0016787	molecular_function	hydrolase activity
A	0032299	cellular_component	ribonuclease H2 complex
A	0043137	biological_process	DNA replication, removal of RNA primer
A	0046872	molecular_function	metal ion binding
A	0090304	biological_process	nucleic acid metabolic process
B	0032299	cellular_component	ribonuclease H2 complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006298	biological_process	mismatch repair
C	0006401	biological_process	RNA catabolic process
C	0032299	cellular_component	ribonuclease H2 complex
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
D	0004540	molecular_function	RNA nuclease activity
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006298	biological_process	mismatch repair
D	0006401	biological_process	RNA catabolic process
D	0016070	biological_process	RNA metabolic process
D	0016787	molecular_function	hydrolase activity
D	0032299	cellular_component	ribonuclease H2 complex
D	0043137	biological_process	DNA replication, removal of RNA primer
D	0046872	molecular_function	metal ion binding
D	0090304	biological_process	nucleic acid metabolic process
E	0032299	cellular_component	ribonuclease H2 complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0006298	biological_process	mismatch repair
F	0006401	biological_process	RNA catabolic process
F	0032299	cellular_component	ribonuclease H2 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
C	MET1
F	MET1
A	ASP141
D	ALA34
D	GLU35
D	ASP141

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER3
F	SER3

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	THR204
A	THR216
D	THR204
D	THR216

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CWY8

Chain	Residue	Details
A	SER257
D	SER257

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER277
D	SER277

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