3JZI

Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003989	molecular_function	acetyl-CoA carboxylase activity
A	0004075	molecular_function	biotin carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0009317	cellular_component	acetyl-CoA carboxylase complex
A	0016874	molecular_function	ligase activity
A	0042803	molecular_function	protein homodimerization activity
A	0045717	biological_process	negative regulation of fatty acid biosynthetic process
A	0046872	molecular_function	metal ion binding
A	2001295	biological_process	malonyl-CoA biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0003989	molecular_function	acetyl-CoA carboxylase activity
B	0004075	molecular_function	biotin carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0009317	cellular_component	acetyl-CoA carboxylase complex
B	0016874	molecular_function	ligase activity
B	0042803	molecular_function	protein homodimerization activity
B	0045717	biological_process	negative regulation of fatty acid biosynthetic process
B	0046872	molecular_function	metal ion binding
B	2001295	biological_process	malonyl-CoA biosynthetic process

PDBデータベースに由来する情報

site_id	AC1
残基数	19
詳細	BINDING SITE FOR RESIDUE JZL A 466

鎖名	残基
A	LYS116
A	LYS202
A	TYR203
A	LEU204
A	HIS209
A	GLN233
A	HIS236
A	LEU278
A	ILE287
A	GLU288
A	HOH640
A	LYS159
A	ALA160
A	GLY164
A	GLY165
A	ARG167
A	MET169
A	TYR199
A	GLU201

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site_id	AC2
残基数	22
詳細	BINDING SITE FOR RESIDUE JZL B 466

鎖名	残基
B	LYS116
B	ILE157
B	LYS159
B	ALA160
B	GLY164
B	GLY165
B	ARG167
B	GLY168
B	MET169
B	TYR199
B	GLU201
B	LYS202
B	TYR203
B	LEU204
B	HIS209
B	GLN233
B	HIS236
B	LEU278
B	ILE287
B	GLU288
B	HOH674
B	HOH689

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00866
残基数	15
詳細	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVIIKASgggGGrG

鎖名	残基	詳細
A	TYR154-GLY168

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site_id	PS00867
残基数	8
詳細	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FIEMNTRI

鎖名	残基	詳細
A	PHE286-ILE293

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	2
詳細	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:19213731

鎖名	残基	詳細
A	ARG292
B	ARG292

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site_id	SWS_FT_FI2
残基数	4
詳細	BINDING: BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8D

鎖名	残基	詳細
A	LYS116
A	GLY165
B	LYS116
B	GLY165

---

site_id	SWS_FT_FI3
残基数	2
詳細	BINDING: BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C, ECO:0007744|PDB:3G8D

鎖名	残基	詳細
A	LYS159
B	LYS159

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site_id	SWS_FT_FI4
残基数	2
詳細	BINDING: BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8C, ECO:0007744|PDB:3G8D

鎖名	残基	詳細
A	GLU201
B	GLU201

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site_id	SWS_FT_FI5
残基数	10
詳細	BINDING: BINDING => ECO:0000269|PubMed:19213731, ECO:0007744|PDB:3G8C

鎖名	残基	詳細
A	HIS209
B	ARG338
A	LYS238
A	ARG292
A	VAL295
A	ARG338
B	HIS209
B	LYS238
B	ARG292
B	VAL295

---

site_id	SWS_FT_FI6
残基数	2
詳細	BINDING: BINDING => ECO:0000269|PubMed:10821865, ECO:0000269|PubMed:19213731, ECO:0007744|PDB:1DV2, ECO:0007744|PDB:3G8C

鎖名	残基	詳細
A	HIS236
B	HIS236

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site_id	SWS_FT_FI7
残基数	6
詳細	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00409

鎖名	残基	詳細
A	GLU276
A	GLU288
A	ASN290
B	GLU276
B	GLU288
B	ASN290

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