3JYC

Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE K A 501

Chain	Residue
A	GLY145
A	K502
A	K502
A	K502
A	GLY145
A	GLY145
A	GLY145
A	TYR146
A	TYR146
A	TYR146
A	TYR146
A	K502

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE K A 502

Chain	Residue
A	ILE144
A	ILE144
A	ILE144
A	ILE144
A	GLY145
A	GLY145
A	GLY145
A	GLY145
A	K501
A	K501
A	K501
A	K501
A	K503
A	K503
A	K503
A	K503

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE K A 503

Chain	Residue
A	THR143
A	THR143
A	THR143
A	THR143
A	ILE144
A	ILE144
A	ILE144
A	ILE144
A	K502
A	K502
A	K502
A	K502
A	K504
A	K504
A	K504
A	K504

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K A 504

Chain	Residue
A	THR143
A	THR143
A	THR143
A	THR143
A	K503
A	K503
A	K503
A	K503

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=M1

Chain	Residue	Details
A	MET82-LEU106

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TOPO_DOM: Extracellular

Chain	Residue	Details
A	ILE107-CYS123
A	THR152-PRO156

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	INTRAMEM:

Chain	Residue	Details
A	VAL124-ASN128

---

site_id	SWS_FT_FI4
Number of Residues	13
Details	INTRAMEM: Helical; Pore-forming; Name=H5

Chain	Residue	Details
A	GLY129-THR142

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	INTRAMEM: Pore-forming

Chain	Residue	Details
A	THR143-VAL151

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	TRANSMEM: Helical; Name=M2

Chain	Residue	Details
A	LEU157-MET181

---