3JAD

Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, strychnine-bound state

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0016594	molecular_function	glycine binding
A	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0016594	molecular_function	glycine binding
B	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0016594	molecular_function	glycine binding
C	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0016594	molecular_function	glycine binding
D	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0016594	molecular_function	glycine binding
E	0022824	molecular_function	transmitter-gated monoatomic ion channel activity
E	0034220	biological_process	monoatomic ion transmembrane transport

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00236
残基数	15
詳細	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLknFPmDvqtC

鎖名	残基	詳細
A	CYS154-CYS168

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	105
詳細	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26344198

鎖名	残基	詳細
A	TYR239-ILE260
B	TYR239-ILE260
C	TYR239-ILE260
D	TYR239-ILE260
E	TYR239-ILE260

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site_id	SWS_FT_FI2
残基数	445
詳細	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26344198

鎖名	残基	詳細
A	ASN261-ALA265
B	ASN261-ALA265
C	ASN261-ALA265
D	ASN261-ALA265
E	ASN261-ALA265

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site_id	SWS_FT_FI3
残基数	100
詳細	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26344198

鎖名	残基	詳細
A	PRO266-SER286
B	PRO266-SER286
C	PRO266-SER286
D	PRO266-SER286
E	PRO266-SER286

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site_id	SWS_FT_FI4
残基数	50
詳細	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26344198

鎖名	残基	詳細
A	ARG287-LYS297
B	ARG287-LYS297
C	ARG287-LYS297
D	ARG287-LYS297
E	ARG287-LYS297

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site_id	SWS_FT_FI5
残基数	100
詳細	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26344198

鎖名	残基	詳細
A	ALA298-ALA318
B	ALA298-ALA318
C	ALA298-ALA318
D	ALA298-ALA318
E	ALA298-ALA318

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site_id	SWS_FT_FI6
残基数	100
詳細	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26344198

鎖名

残基

詳細

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site_id	SWS_FT_FI7
残基数	15
詳細	BINDING: BINDING => ECO:0000250|UniProtKB:P23415

鎖名	残基	詳細
A	GLU208
A	ASP210
A	HIS231
B	GLU208
B	ASP210
B	HIS231
C	GLU208
C	ASP210
C	HIS231
D	GLU208
D	ASP210
D	HIS231
E	GLU208
E	ASP210
E	HIS231

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site_id	SWS_FT_FI8
残基数	5
詳細	BINDING: BINDING => ECO:0000269|PubMed:26344198

鎖名	残基	詳細
A	TYR218
B	TYR218
C	TYR218
D	TYR218
E	TYR218

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site_id	SWS_FT_FI9
残基数	5
詳細	SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:26344198

鎖名	残基	詳細
A	LEU277
B	LEU277
C	LEU277
D	LEU277
E	LEU277

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site_id	SWS_FT_FI10
残基数	5
詳細	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26344198

鎖名	残基	詳細
A	ASN54
B	ASN54
C	ASN54
D	ASN54
E	ASN54

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