3J5Q

Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005576	cellular_component	extracellular region
C	0008200	molecular_function	ion channel inhibitor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0005216	molecular_function	monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
F	0005576	cellular_component	extracellular region
F	0008200	molecular_function	ion channel inhibitor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
H	0005576	cellular_component	extracellular region
H	0008200	molecular_function	ion channel inhibitor activity

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	4
詳細	SITE: Involved in active face => ECO:0000250

鎖名	残基	詳細
A	TRP30
B	GLU536-THR556
B	MET572-ILE599
B	LEU681-GLU709
E	ILE433-TYR453
E	TYR472-LEU497
E	TYR511-PHE531
E	GLU536-THR556
E	MET572-ILE599
E	LEU681-GLU709
G	ILE433-TYR453
C	TRP30
G	TYR472-LEU497
G	TYR511-PHE531
G	GLU536-THR556
G	MET572-ILE599
G	LEU681-GLU709
F	TRP30
H	TRP30
D	MET572-ILE599
D	LEU681-GLU709
B	ILE433-TYR453
B	TYR472-LEU497
B	TYR511-PHE531

---

site_id	SWS_FT_FI2
残基数	184
詳細	TOPO_DOM: Extracellular => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200

鎖名	残基	詳細
D	TYR454-ASP471
G	TYR454-ASP471
G	SER532-LYS535
G	GLU600-PHE649
D	SER532-LYS535
D	GLU600-PHE649
B	TYR454-ASP471
B	SER532-LYS535
B	GLU600-PHE649
E	TYR454-ASP471
E	SER532-LYS535
E	GLU600-PHE649

---

site_id	SWS_FT_FI3
残基数	104
詳細	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200

鎖名	残基	詳細
D	GLN498-SER510
D	ARG557-LYS571
B	GLN498-SER510
B	ARG557-LYS571
E	GLN498-SER510
E	ARG557-LYS571
G	GLN498-SER510
G	ARG557-LYS571

---

site_id	SWS_FT_FI4
残基数	88
詳細	INTRAMEM: Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826

鎖名	残基	詳細
D	THR650-ILE672
B	THR650-ILE672
E	THR650-ILE672
G	THR650-ILE672

---

site_id	SWS_FT_FI5
残基数	12
詳細	BINDING: BINDING => ECO:0007744|PDB:2PNN

鎖名	残基	詳細
D	ARG115
G	ARG115
G	LYS155
G	GLU210
D	LYS155
D	GLU210
B	ARG115
B	LYS155
B	GLU210
E	ARG115
E	LYS155
E	GLU210

---

site_id	SWS_FT_FI6
残基数	12
詳細	BINDING: BINDING => ECO:0007744|PDB:2NYJ, ECO:0007744|PDB:2PNN

鎖名	残基	詳細
D	LYS160
G	LYS160
G	ASN164
G	TYR199
D	ASN164
D	TYR199
B	LYS160
B	ASN164
B	TYR199
E	LYS160
E	ASN164
E	TYR199

---

site_id	SWS_FT_FI7
残基数	12
詳細	BINDING: BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX

鎖名	残基	詳細
D	TYR511
G	TYR511
G	THR550
G	ARG557
D	THR550
D	ARG557
B	TYR511
B	THR550
B	ARG557
E	TYR511
E	THR550
E	ARG557

---

site_id	SWS_FT_FI8
残基数	4
詳細	BINDING: BINDING => ECO:0000250|UniProtKB:Q9R186

鎖名	残基	詳細
D	LEU669
B	LEU669
E	LEU669
G	LEU669

---

site_id	SWS_FT_FI9
残基数	4
詳細	MOD_RES: Phosphoserine; by PKA and PKD => ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:15471852

鎖名	残基	詳細
D	SER116
B	SER116
E	SER116
G	SER116

---

site_id	SWS_FT_FI10
残基数	8
詳細	MOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871

鎖名	残基	詳細
D	THR144
D	THR370
B	THR144
B	THR370
E	THR144
E	THR370
G	THR144
G	THR370

---

site_id	SWS_FT_FI11
残基数	4
詳細	MOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912

鎖名	残基	詳細
D	SER502
B	SER502
E	SER502
G	SER502

---

site_id	SWS_FT_FI12
残基数	4
詳細	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14630912

鎖名	残基	詳細
D	UNK728
B	UNK728
E	UNK728
G	UNK728

---

site_id	SWS_FT_FI13
残基数	4
詳細	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872

鎖名	残基	詳細
D	TYR627
B	TYR627
E	TYR627
G	TYR627

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