Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3GTU

LIGAND-FREE HETERODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M2-3 (EC 2.5.1.18), MONOCLINIC CRYSTAL FORM

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0005102molecular_functionsignaling receptor binding
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006749biological_processglutathione metabolic process
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016529cellular_componentsarcoplasmic reticulum
A0016740molecular_functiontransferase activity
A0018916biological_processnitrobenzene metabolic process
A0019899molecular_functionenzyme binding
A0042178biological_processxenobiotic catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043295molecular_functionglutathione binding
A0043651biological_processlinoleic acid metabolic process
A0045171cellular_componentintercellular bridge
A0051122biological_processhepoxilin biosynthetic process
A0055119biological_processrelaxation of cardiac muscle
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0070062cellular_componentextracellular exosome
A0070458biological_processcellular detoxification of nitrogen compound
A0071313biological_processcellular response to caffeine
A0098869biological_processcellular oxidant detoxification
B0004364molecular_functionglutathione transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006749biological_processglutathione metabolic process
B0008065biological_processestablishment of blood-nerve barrier
B0016740molecular_functiontransferase activity
B0018916biological_processnitrobenzene metabolic process
B0019899molecular_functionenzyme binding
B0035686cellular_componentsperm fibrous sheath
B0042178biological_processxenobiotic catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043295molecular_functionglutathione binding
B0043627biological_processresponse to estrogen
B0045171cellular_componentintercellular bridge
B0070062cellular_componentextracellular exosome
B0070458biological_processcellular detoxification of nitrogen compound
C0004364molecular_functionglutathione transferase activity
C0004602molecular_functionglutathione peroxidase activity
C0005102molecular_functionsignaling receptor binding
C0005504molecular_functionfatty acid binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006749biological_processglutathione metabolic process
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C0016529cellular_componentsarcoplasmic reticulum
C0016740molecular_functiontransferase activity
C0018916biological_processnitrobenzene metabolic process
C0019899molecular_functionenzyme binding
C0042178biological_processxenobiotic catabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043295molecular_functionglutathione binding
C0043651biological_processlinoleic acid metabolic process
C0045171cellular_componentintercellular bridge
C0051122biological_processhepoxilin biosynthetic process
C0055119biological_processrelaxation of cardiac muscle
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0070062cellular_componentextracellular exosome
C0070458biological_processcellular detoxification of nitrogen compound
C0071313biological_processcellular response to caffeine
C0098869biological_processcellular oxidant detoxification
D0004364molecular_functionglutathione transferase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006749biological_processglutathione metabolic process
D0008065biological_processestablishment of blood-nerve barrier
D0016740molecular_functiontransferase activity
D0018916biological_processnitrobenzene metabolic process
D0019899molecular_functionenzyme binding
D0035686cellular_componentsperm fibrous sheath
D0042178biological_processxenobiotic catabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043295molecular_functionglutathione binding
D0043627biological_processresponse to estrogen
D0045171cellular_componentintercellular bridge
D0070062cellular_componentextracellular exosome
D0070458biological_processcellular detoxification of nitrogen compound
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P08515
ChainResidueDetails
BTYR10
BTRP49
BASN62
BGLN75
DTYR10
DTRP49
DASN62
DGLN75

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BTYR119
DTYR119

site_idSWS_FT_FI3
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS53
CASP116
BLYS72
DLYS53
DLYS72

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for substrate specificity
ChainResidueDetails
ALYS210
CLYS210

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08010
ChainResidueDetails
ATYR27
AGLN44
CTYR27
CGLN44

218853

건을2024-04-24부터공개중

PDB statisticsPDBj update infoContact PDBjnumon