3FFZ

Domain organization in Clostridium butulinum neurotoxin type E is unique: Its implication in faster translocation

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004222	molecular_function	metalloendopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0008289	molecular_function	lipid binding
A	0008320	molecular_function	protein transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0020002	cellular_component	host cell plasma membrane
A	0030430	cellular_component	host cell cytoplasm
A	0033644	cellular_component	host cell membrane
A	0035821	biological_process	modulation of process of another organism
A	0044161	cellular_component	host cell cytoplasmic vesicle
A	0044164	cellular_component	host cell cytosol
A	0044221	cellular_component	host cell synapse
A	0044231	cellular_component	host cell presynaptic membrane
A	0046872	molecular_function	metal ion binding
A	0071806	biological_process	protein transmembrane transport
A	0090729	molecular_function	toxin activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0008289	molecular_function	lipid binding
B	0008320	molecular_function	protein transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0020002	cellular_component	host cell plasma membrane
B	0030430	cellular_component	host cell cytoplasm
B	0033644	cellular_component	host cell membrane
B	0035821	biological_process	modulation of process of another organism
B	0044161	cellular_component	host cell cytoplasmic vesicle
B	0044164	cellular_component	host cell cytosol
B	0044221	cellular_component	host cell synapse
B	0044231	cellular_component	host cell presynaptic membrane
B	0046872	molecular_function	metal ion binding
B	0071806	biological_process	protein transmembrane transport
B	0090729	molecular_function	toxin activity

PDBデータベースに由来する情報

site_id	AC1
残基数	5
詳細	BINDING SITE FOR RESIDUE ZN A1300

鎖名	残基
A	HIS212
A	HIS216
A	GLU251
A	HOH1289
A	HOH1318

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site_id	AC2
残基数	5
詳細	BINDING SITE FOR RESIDUE NA A1301

鎖名	残基
A	HOH1317
A	ALA544
A	GLU547
A	GLN548
A	LYS550

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site_id	AC3
残基数	5
詳細	BINDING SITE FOR RESIDUE NA A1302

鎖名	残基
A	VAL593
A	ILE596
A	ALA597
A	ILE599
A	HOH1314

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site_id	AC4
残基数	2
詳細	BINDING SITE FOR RESIDUE ACT A1303

鎖名	残基
A	TYR879
A	TYR1041

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site_id	AC5
残基数	5
詳細	BINDING SITE FOR RESIDUE ZN B1300

鎖名	残基
B	HIS212
B	HIS216
B	GLU251
B	HOH1275
B	HOH1284

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site_id	AC6
残基数	5
詳細	BINDING SITE FOR RESIDUE NA B1302

鎖名	残基
B	VAL593
B	ILE596
B	ILE599
B	SER600
B	HOH1283

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site_id	AC7
残基数	2
詳細	BINDING SITE FOR RESIDUE ACT B1303

鎖名	残基
B	TYR879
B	TYR881

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00142
残基数	10
詳細	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLMHELIHSL

鎖名	残基	詳細
A	THR209-LEU218

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	2
詳細	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000305|PubMed:15157097

鎖名	残基	詳細
A	GLU213
B	GLU213

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site_id	SWS_FT_FI2
残基数	4
詳細	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0007744|PDB:1T3A, ECO:0007744|PDB:1T3C, ECO:0007744|PDB:1ZKW, ECO:0007744|PDB:1ZKX, ECO:0007744|PDB:1ZL6, ECO:0007744|PDB:1ZN3, ECO:0007744|PDB:3FFZ

鎖名	残基	詳細
A	HIS212
A	HIS216
B	HIS212
B	HIS216

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site_id	SWS_FT_FI3
残基数	2
詳細	BINDING: BINDING => ECO:0007744|PDB:1T3A, ECO:0007744|PDB:1T3C, ECO:0007744|PDB:1ZKW, ECO:0007744|PDB:1ZKX, ECO:0007744|PDB:1ZL6, ECO:0007744|PDB:1ZN3, ECO:0007744|PDB:3FFZ

鎖名	残基	詳細
A	GLU251
B	GLU251

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