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3DU8

Crystal structure of GSK-3 beta in complex with NMS-869553A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001837biological_processepithelial to mesenchymal transition
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002020molecular_functionprotease binding
A0002039molecular_functionp53 binding
A0003170biological_processheart valve development
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005977biological_processglycogen metabolic process
A0006468biological_processprotein phosphorylation
A0006983biological_processER overload response
A0007212biological_processdopamine receptor signaling pathway
A0007399biological_processnervous system development
A0007623biological_processcircadian rhythm
A0008013molecular_functionbeta-catenin binding
A0008286biological_processinsulin receptor signaling pathway
A0009968biological_processnegative regulation of signal transduction
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010822biological_processobsolete positive regulation of mitochondrion organization
A0010975biological_processregulation of neuron projection development
A0010977biological_processnegative regulation of neuron projection development
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019082biological_processviral protein processing
A0019901molecular_functionprotein kinase binding
A0021766biological_processhippocampus development
A0030010biological_processestablishment of cell polarity
A0030011biological_processmaintenance of cell polarity
A0030154biological_processcell differentiation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030516biological_processregulation of axon extension
A0030877cellular_componentbeta-catenin destruction complex
A0031175biological_processneuron projection development
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031398biological_processpositive regulation of protein ubiquitination
A0031625molecular_functionubiquitin protein ligase binding
A0032007biological_processnegative regulation of TOR signaling
A0032092biological_processpositive regulation of protein binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032515biological_processnegative regulation of phosphoprotein phosphatase activity
A0032886biological_processregulation of microtubule-based process
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034452molecular_functiondynactin binding
A0035556biological_processintracellular signal transduction
A0036016biological_processcellular response to interleukin-3
A0042752biological_processregulation of circadian rhythm
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0043547biological_processpositive regulation of GTPase activity
A0045597biological_processpositive regulation of cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045719biological_processnegative regulation of glycogen biosynthetic process
A0045724biological_processpositive regulation of cilium assembly
A0045732biological_processpositive regulation of protein catabolic process
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046777biological_processprotein autophosphorylation
A0046825biological_processregulation of protein export from nucleus
A0046827biological_processpositive regulation of protein export from nucleus
A0048156molecular_functiontau protein binding
A0048511biological_processrhythmic process
A0048814biological_processregulation of dendrite morphogenesis
A0050321molecular_functiontau-protein kinase activity
A0050770biological_processregulation of axonogenesis
A0051059molecular_functionNF-kappaB binding
A0051093biological_processnegative regulation of developmental process
A0051128biological_processregulation of cellular component organization
A0060070biological_processcanonical Wnt signaling pathway
A0060079biological_processexcitatory postsynaptic potential
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070507biological_processregulation of microtubule cytoskeleton organization
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071109biological_processsuperior temporal gyrus development
A0071300biological_processcellular response to retinoic acid
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0106027biological_processneuron projection organization
A0106310molecular_functionprotein serine kinase activity
A0150101biological_processregulation of microtubule anchoring at centrosome
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1900271biological_processregulation of long-term synaptic potentiation
A1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
A1901984biological_processnegative regulation of protein acetylation
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903566biological_processpositive regulation of protein localization to cilium
A1904339biological_processnegative regulation of dopaminergic neuron differentiation
A1904646biological_processcellular response to amyloid-beta
A1904781biological_processpositive regulation of protein localization to centrosome
A1904886biological_processbeta-catenin destruction complex disassembly
A1990909cellular_componentWnt signalosome
A2000077biological_processnegative regulation of type B pancreatic cell development
A2000466biological_processnegative regulation of glycogen (starch) synthase activity
A2000740biological_processnegative regulation of mesenchymal stem cell differentiation
B0000166molecular_functionnucleotide binding
B0001837biological_processepithelial to mesenchymal transition
B0001954biological_processpositive regulation of cell-matrix adhesion
B0002020molecular_functionprotease binding
B0002039molecular_functionp53 binding
B0003170biological_processheart valve development
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005977biological_processglycogen metabolic process
B0006468biological_processprotein phosphorylation
B0006983biological_processER overload response
B0007212biological_processdopamine receptor signaling pathway
B0007399biological_processnervous system development
B0007623biological_processcircadian rhythm
B0008013molecular_functionbeta-catenin binding
B0008286biological_processinsulin receptor signaling pathway
B0009968biological_processnegative regulation of signal transduction
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010822biological_processobsolete positive regulation of mitochondrion organization
B0010975biological_processregulation of neuron projection development
B0010977biological_processnegative regulation of neuron projection development
B0016020cellular_componentmembrane
B0016055biological_processWnt signaling pathway
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0019082biological_processviral protein processing
B0019901molecular_functionprotein kinase binding
B0021766biological_processhippocampus development
B0030010biological_processestablishment of cell polarity
B0030011biological_processmaintenance of cell polarity
B0030154biological_processcell differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030516biological_processregulation of axon extension
B0030877cellular_componentbeta-catenin destruction complex
B0031175biological_processneuron projection development
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031398biological_processpositive regulation of protein ubiquitination
B0031625molecular_functionubiquitin protein ligase binding
B0032007biological_processnegative regulation of TOR signaling
B0032092biological_processpositive regulation of protein binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032515biological_processnegative regulation of phosphoprotein phosphatase activity
B0032886biological_processregulation of microtubule-based process
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034452molecular_functiondynactin binding
B0035556biological_processintracellular signal transduction
B0036016biological_processcellular response to interleukin-3
B0042752biological_processregulation of circadian rhythm
B0043066biological_processnegative regulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0043547biological_processpositive regulation of GTPase activity
B0045597biological_processpositive regulation of cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045719biological_processnegative regulation of glycogen biosynthetic process
B0045724biological_processpositive regulation of cilium assembly
B0045732biological_processpositive regulation of protein catabolic process
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046777biological_processprotein autophosphorylation
B0046825biological_processregulation of protein export from nucleus
B0046827biological_processpositive regulation of protein export from nucleus
B0048156molecular_functiontau protein binding
B0048511biological_processrhythmic process
B0048814biological_processregulation of dendrite morphogenesis
B0050321molecular_functiontau-protein kinase activity
B0050770biological_processregulation of axonogenesis
B0051059molecular_functionNF-kappaB binding
B0051093biological_processnegative regulation of developmental process
B0051128biological_processregulation of cellular component organization
B0060070biological_processcanonical Wnt signaling pathway
B0060079biological_processexcitatory postsynaptic potential
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071109biological_processsuperior temporal gyrus development
B0071300biological_processcellular response to retinoic acid
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0097191biological_processextrinsic apoptotic signaling pathway
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B0106027biological_processneuron projection organization
B0106310molecular_functionprotein serine kinase activity
B0150101biological_processregulation of microtubule anchoring at centrosome
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1900271biological_processregulation of long-term synaptic potentiation
B1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
B1901984biological_processnegative regulation of protein acetylation
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1903566biological_processpositive regulation of protein localization to cilium
B1904339biological_processnegative regulation of dopaminergic neuron differentiation
B1904646biological_processcellular response to amyloid-beta
B1904781biological_processpositive regulation of protein localization to centrosome
B1904886biological_processbeta-catenin destruction complex disassembly
B1990909cellular_componentWnt signalosome
B2000077biological_processnegative regulation of type B pancreatic cell development
B2000466biological_processnegative regulation of glycogen (starch) synthase activity
B2000740biological_processnegative regulation of mesenchymal stem cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 553 A 553
ChainResidue
APHE67
AALA83
ALYS85
AASP133
ATYR134
AASN186
ALEU188
AASP200

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 553 B 553
ChainResidue
BLYS85
BASP133
BTYR134
BASN186
BLEU188
BASP200
BALA83

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGNGSFGVVYqAklcdsgelv.........AIKK
ChainResidueDetails
AILE62-LYS86

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IcHrDIKpqNLLL
ChainResidueDetails
AILE177-LEU189

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP181
BASP181

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE62
BILE62

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:17050006
ChainResidueDetails
ALYS85
BLYS85

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKB/AKT1, RPS6KA3 and SGK3 => ECO:0000269|PubMed:12054501, ECO:0000269|PubMed:16484495, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:24391509, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:8250835
ChainResidueDetails
ASER9
BSER9

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:12554650, ECO:0000269|PubMed:25169422
ChainResidueDetails
ATYR216
BTYR216

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WV60
ChainResidueDetails
ASER389
BSER389

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR390
BTHR390

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ATHR402
BTHR402

218853

数据于2024-04-24公开中

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