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3D87

Crystal structure of Interleukin-23

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002230biological_processpositive regulation of defense response to virus by host
A0002376biological_processimmune system process
A0002827biological_processpositive regulation of T-helper 1 type immune response
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005788cellular_componentendoplasmic reticulum lumen
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0010536biological_processpositive regulation of activation of Janus kinase activity
A0032693biological_processnegative regulation of interleukin-10 production
A0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
A0032729biological_processpositive regulation of type II interferon production
A0032733biological_processpositive regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032816biological_processpositive regulation of natural killer cell activation
A0032819biological_processpositive regulation of natural killer cell proliferation
A0034105biological_processpositive regulation of tissue remodeling
A0042098biological_processT cell proliferation
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0042509biological_processregulation of tyrosine phosphorylation of STAT protein
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0043382biological_processpositive regulation of memory T cell differentiation
A0045087biological_processinnate immune response
A0045519molecular_functioninterleukin-23 receptor binding
A0045672biological_processpositive regulation of osteoclast differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048771biological_processtissue remodeling
A0050729biological_processpositive regulation of inflammatory response
A0050829biological_processdefense response to Gram-negative bacterium
A0051135biological_processpositive regulation of NK T cell activation
A0051142biological_processpositive regulation of NK T cell proliferation
A0051607biological_processdefense response to virus
A0070743cellular_componentinterleukin-23 complex
A0090023biological_processpositive regulation of neutrophil chemotaxis
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A2000318biological_processpositive regulation of T-helper 17 type immune response
A2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
B0001817biological_processregulation of cytokine production
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002230biological_processpositive regulation of defense response to virus by host
B0002323biological_processnatural killer cell activation involved in immune response
B0002827biological_processpositive regulation of T-helper 1 type immune response
B0002860biological_processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
B0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
B0004896molecular_functioncytokine receptor activity
B0005125molecular_functioncytokine activity
B0005126molecular_functioncytokine receptor binding
B0005143molecular_functioninterleukin-12 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005788cellular_componentendoplasmic reticulum lumen
B0005829cellular_componentcytosol
B0007166biological_processcell surface receptor signaling pathway
B0008083molecular_functiongrowth factor activity
B0008283biological_processcell population proliferation
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010033biological_processresponse to organic substance
B0010224biological_processresponse to UV-B
B0010536biological_processpositive regulation of activation of Janus kinase activity
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0019221biological_processcytokine-mediated signaling pathway
B0019953biological_processsexual reproduction
B0019955molecular_functioncytokine binding
B0030101biological_processnatural killer cell activation
B0031906cellular_componentlate endosome lumen
B0032693biological_processnegative regulation of interleukin-10 production
B0032700biological_processnegative regulation of interleukin-17 production
B0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
B0032729biological_processpositive regulation of type II interferon production
B0032733biological_processpositive regulation of interleukin-10 production
B0032735biological_processpositive regulation of interleukin-12 production
B0032740biological_processpositive regulation of interleukin-17 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032816biological_processpositive regulation of natural killer cell activation
B0032819biological_processpositive regulation of natural killer cell proliferation
B0032946biological_processpositive regulation of mononuclear cell proliferation
B0034105biological_processpositive regulation of tissue remodeling
B0034393biological_processpositive regulation of smooth muscle cell apoptotic process
B0035722biological_processinterleukin-12-mediated signaling pathway
B0042088biological_processT-helper 1 type immune response
B0042093biological_processT-helper cell differentiation
B0042098biological_processT cell proliferation
B0042102biological_processpositive regulation of T cell proliferation
B0042104biological_processpositive regulation of activated T cell proliferation
B0042164molecular_functioninterleukin-12 alpha subunit binding
B0042509biological_processregulation of tyrosine phosphorylation of STAT protein
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0042802molecular_functionidentical protein binding
B0042832biological_processdefense response to protozoan
B0043235cellular_componentreceptor complex
B0043382biological_processpositive regulation of memory T cell differentiation
B0043514cellular_componentinterleukin-12 complex
B0044877molecular_functionprotein-containing complex binding
B0045519molecular_functioninterleukin-23 receptor binding
B0045672biological_processpositive regulation of osteoclast differentiation
B0045785biological_processpositive regulation of cell adhesion
B0046982molecular_functionprotein heterodimerization activity
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0050671biological_processpositive regulation of lymphocyte proliferation
B0050709biological_processnegative regulation of protein secretion
B0050729biological_processpositive regulation of inflammatory response
B0050829biological_processdefense response to Gram-negative bacterium
B0051135biological_processpositive regulation of NK T cell activation
B0051142biological_processpositive regulation of NK T cell proliferation
B0051607biological_processdefense response to virus
B0070743cellular_componentinterleukin-23 complex
B0071222biological_processcellular response to lipopolysaccharide
B0071346biological_processcellular response to type II interferon
B1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B2000318biological_processpositive regulation of T-helper 17 type immune response
B2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
C0001916biological_processpositive regulation of T cell mediated cytotoxicity
C0002230biological_processpositive regulation of defense response to virus by host
C0002376biological_processimmune system process
C0002827biological_processpositive regulation of T-helper 1 type immune response
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005788cellular_componentendoplasmic reticulum lumen
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007165biological_processsignal transduction
C0010536biological_processpositive regulation of activation of Janus kinase activity
C0032693biological_processnegative regulation of interleukin-10 production
C0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
C0032729biological_processpositive regulation of type II interferon production
C0032733biological_processpositive regulation of interleukin-10 production
C0032735biological_processpositive regulation of interleukin-12 production
C0032740biological_processpositive regulation of interleukin-17 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032816biological_processpositive regulation of natural killer cell activation
C0032819biological_processpositive regulation of natural killer cell proliferation
C0034105biological_processpositive regulation of tissue remodeling
C0042098biological_processT cell proliferation
C0042102biological_processpositive regulation of T cell proliferation
C0042104biological_processpositive regulation of activated T cell proliferation
C0042509biological_processregulation of tyrosine phosphorylation of STAT protein
C0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
C0043382biological_processpositive regulation of memory T cell differentiation
C0045087biological_processinnate immune response
C0045519molecular_functioninterleukin-23 receptor binding
C0045672biological_processpositive regulation of osteoclast differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048771biological_processtissue remodeling
C0050729biological_processpositive regulation of inflammatory response
C0050829biological_processdefense response to Gram-negative bacterium
C0051135biological_processpositive regulation of NK T cell activation
C0051142biological_processpositive regulation of NK T cell proliferation
C0051607biological_processdefense response to virus
C0070743cellular_componentinterleukin-23 complex
C0090023biological_processpositive regulation of neutrophil chemotaxis
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C2000318biological_processpositive regulation of T-helper 17 type immune response
C2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
D0001817biological_processregulation of cytokine production
D0001916biological_processpositive regulation of T cell mediated cytotoxicity
D0002230biological_processpositive regulation of defense response to virus by host
D0002323biological_processnatural killer cell activation involved in immune response
D0002827biological_processpositive regulation of T-helper 1 type immune response
D0002860biological_processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
D0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
D0004896molecular_functioncytokine receptor activity
D0005125molecular_functioncytokine activity
D0005126molecular_functioncytokine receptor binding
D0005143molecular_functioninterleukin-12 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005788cellular_componentendoplasmic reticulum lumen
D0005829cellular_componentcytosol
D0007166biological_processcell surface receptor signaling pathway
D0008083molecular_functiongrowth factor activity
D0008283biological_processcell population proliferation
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0010033biological_processresponse to organic substance
D0010224biological_processresponse to UV-B
D0010536biological_processpositive regulation of activation of Janus kinase activity
D0016020cellular_componentmembrane
D0016477biological_processcell migration
D0019221biological_processcytokine-mediated signaling pathway
D0019953biological_processsexual reproduction
D0019955molecular_functioncytokine binding
D0030101biological_processnatural killer cell activation
D0031906cellular_componentlate endosome lumen
D0032693biological_processnegative regulation of interleukin-10 production
D0032700biological_processnegative regulation of interleukin-17 production
D0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
D0032729biological_processpositive regulation of type II interferon production
D0032733biological_processpositive regulation of interleukin-10 production
D0032735biological_processpositive regulation of interleukin-12 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032816biological_processpositive regulation of natural killer cell activation
D0032819biological_processpositive regulation of natural killer cell proliferation
D0032946biological_processpositive regulation of mononuclear cell proliferation
D0034105biological_processpositive regulation of tissue remodeling
D0034393biological_processpositive regulation of smooth muscle cell apoptotic process
D0035722biological_processinterleukin-12-mediated signaling pathway
D0042088biological_processT-helper 1 type immune response
D0042093biological_processT-helper cell differentiation
D0042098biological_processT cell proliferation
D0042102biological_processpositive regulation of T cell proliferation
D0042104biological_processpositive regulation of activated T cell proliferation
D0042164molecular_functioninterleukin-12 alpha subunit binding
D0042509biological_processregulation of tyrosine phosphorylation of STAT protein
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0042802molecular_functionidentical protein binding
D0042832biological_processdefense response to protozoan
D0043235cellular_componentreceptor complex
D0043382biological_processpositive regulation of memory T cell differentiation
D0043514cellular_componentinterleukin-12 complex
D0044877molecular_functionprotein-containing complex binding
D0045519molecular_functioninterleukin-23 receptor binding
D0045672biological_processpositive regulation of osteoclast differentiation
D0045785biological_processpositive regulation of cell adhesion
D0046982molecular_functionprotein heterodimerization activity
D0048662biological_processnegative regulation of smooth muscle cell proliferation
D0050671biological_processpositive regulation of lymphocyte proliferation
D0050709biological_processnegative regulation of protein secretion
D0050729biological_processpositive regulation of inflammatory response
D0050829biological_processdefense response to Gram-negative bacterium
D0051135biological_processpositive regulation of NK T cell activation
D0051142biological_processpositive regulation of NK T cell proliferation
D0051607biological_processdefense response to virus
D0070743cellular_componentinterleukin-23 complex
D0071222biological_processcellular response to lipopolysaccharide
D0071346biological_processcellular response to type II interferon
D1900747biological_processnegative regulation of vascular endothelial growth factor signaling pathway
D1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
D1903588biological_processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
D2000318biological_processpositive regulation of T-helper 17 type immune response
D2000330biological_processpositive regulation of T-helper 17 cell lineage commitment
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS01354
残基数43
詳細HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. IkPDPPknLqlkplknsrq.VevsWeyPdTWstphsyFsLtFcV
鎖名残基詳細
BILE211-VAL253

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数2
詳細CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
鎖名残基詳細
BASN113
DASN113

site_idSWS_FT_FI2
残基数2
詳細CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10899108
鎖名残基詳細
BGLN200
DGLN200

site_idSWS_FT_FI3
残基数2
詳細CARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:10207176
鎖名残基詳細
BTRP297
DTRP297

218500

件を2024-04-17に公開中

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