3CF6

Structure of Epac2 in complex with cyclic-AMP and Rap

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0007264	biological_process	small GTPase-mediated signal transduction
R	0000166	molecular_function	nucleotide binding
R	0003924	molecular_function	GTPase activity
R	0003925	molecular_function	G protein activity
R	0005515	molecular_function	protein binding
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005811	cellular_component	lipid droplet
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0005911	cellular_component	cell-cell junction
R	0007165	biological_process	signal transduction
R	0007264	biological_process	small GTPase-mediated signal transduction
R	0008283	biological_process	cell population proliferation
R	0016020	cellular_component	membrane
R	0016787	molecular_function	hydrolase activity
R	0017156	biological_process	calcium-ion regulated exocytosis
R	0019003	molecular_function	GDP binding
R	0030033	biological_process	microvillus assembly
R	0032486	biological_process	Rap protein signal transduction
R	0033625	biological_process	positive regulation of integrin activation
R	0035577	cellular_component	azurophil granule membrane
R	0044877	molecular_function	protein-containing complex binding
R	0045121	cellular_component	membrane raft
R	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
R	0051649	biological_process	establishment of localization in cell
R	0061028	biological_process	establishment of endothelial barrier
R	0070062	cellular_component	extracellular exosome
R	0070161	cellular_component	anchoring junction
R	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
R	0071320	biological_process	cellular response to cAMP
R	0098978	cellular_component	glutamatergic synapse
R	0099010	biological_process	modification of postsynaptic structure
R	1901888	biological_process	regulation of cell junction assembly
R	2000114	biological_process	regulation of establishment of cell polarity
R	2000301	biological_process	negative regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 R 168

Chain	Residue
R	SER11
R	GLY12
R	GLY13
R	GLY15
R	LYS16
R	SER17
R	ALA59
R	HOH171

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SP1 E 2

Chain	Residue
E	ILE388
E	CYS395
E	PHE403
E	GLY404
E	LEU406
E	ALA407
E	ARG414
E	ALA415
E	LEU449
E	LYS450
E	GLU451
E	LYS489
E	HOH1054
E	HOH1077
E	PHE367

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site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SP1 E 3

Chain	Residue
E	ASN368
E	ILE388
E	GLY392
E	SER417
E	GLN539
E	SER541
E	LYS556
E	ASP594
E	MET597
E	MET598
E	HOH1033
E	HOH1052

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Functional Information from PROSITE/UniProt

site_id	PS00720
Number of Residues	30
Details	RASGEF Ras Guanine-nucleotide exchange factors domain signature. IPFmPllIkDMtfthegnktfidnl.....................VNFeK

Chain	Residue	Details
E	ILE903-LYS932

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140

Chain	Residue	Details
R	GLY10
R	ASP57
R	ASN116
R	SER147

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: ADP-ribosylserine; by botulinum toxin => ECO:0000305|PubMed:3141412

Chain	Residue	Details
R	SER39

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