3ASX

Human Squalene synthase in complex with 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004310	molecular_function	farnesyl-diphosphate farnesyltransferase activity
A	0004311	molecular_function	farnesyltranstransferase activity
A	0008610	biological_process	lipid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 400

Chain	Residue
A	ARG148
A	ARG149
A	HIS173
A	TYR174
A	HOH412
A	HOH466
A	HOH494

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site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE D99 A 1

Chain	Residue
A	VAL179
A	LEU183
A	GLN212
A	PHE288
A	PRO292
A	MET295
A	HOH446
A	HOH638
A	SER53
A	PHE54

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Functional Information from PROSITE/UniProt

site_id	PS01044
Number of Residues	16
Details	SQUALEN_PHYTOEN_SYN_1 Squalene and phytoene synthases signature 1. YChyVAGLVGigLsrL

Chain	Residue	Details
A	TYR171-LEU186

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site_id	PS01045
Number of Residues	26
Details	SQUALEN_PHYTOEN_SYN_2 Squalene and phytoene synthases signature 2. MGlflQkt.NIiRDYleDqqgg...ReFwP

Chain	Residue	Details
A	MET207-PRO232

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	SER284-TYR304

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000305|PubMed:24531458

Chain	Residue	Details
A	ARG52
A	ARG77
A	ARG218
A	LYS315
A	ARG317

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:24531458, ECO:0007744|PDB:3WEG, ECO:0007744|PDB:3WEH

Chain	Residue	Details
A	ASP80
A	GLU83
A	ASP84

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 264

Chain	Residue	Details
A	TYR171	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ARG218	electrostatic stabiliser, hydrogen bond donor, promote heterolysis
A	ARG228	electrostatic stabiliser, hydrogen bond donor, promote heterolysis
A	PHE288	polar/non-polar interaction, steric role, van der waals interaction

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