2XCF

Crystal structure of HCV NS3 protease with a boronate inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	transformation of host cell by virus
A	0033644	cellular_component	host cell membrane
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0019062	biological_process	virion attachment to host cell
B	0019087	biological_process	transformation of host cell by virus
B	0033644	cellular_component	host cell membrane
B	0044423	cellular_component	virion component
B	0046718	biological_process	symbiont entry into host cell
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	CYS97
A	CYS99
A	CYS145
A	HOH2049

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1181

Chain	Residue
A	ALA5
A	ALA111
A	HOH2002
A	HOH2003
A	HOH2035

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site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BBQ A 1182

Chain	Residue
A	GLN41
A	HIS57
A	ASP81
A	LEU135
A	GLY137
A	SER138
A	ALA139
A	PHE154
A	ARG155
A	ALA156
A	ALA157

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 400

Chain	Residue
B	CYS97
B	CYS99
B	CYS145
B	HOH2051

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 1041

Chain	Residue
A	THR4
C	LEU31
C	GLY33
C	HOH2001
C	HOH2002

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