2XBU
Saccharomyces cerevisiae hypoxanthine-guanine phosphoribosyltransferase in complex with GMP (monoclinic crystal form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0032265 | biological_process | XMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| A | 1901576 | biological_process | organic substance biosynthetic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0032265 | biological_process | XMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 1901576 | biological_process | organic substance biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 1219 |
| Chain | Residue |
| A | ARG60 |
| A | HOH2265 |
| A | HOH2266 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 5GP A 1220 |
| Chain | Residue |
| A | TRP188 |
| A | TYR189 |
| A | TYR191 |
| A | GLU194 |
| A | HOH2150 |
| A | HOH2151 |
| A | HOH2152 |
| A | HOH2267 |
| A | HOH2268 |
| A | HOH2269 |
| A | HOH2271 |
| A | ASP114 |
| A | THR115 |
| A | ARG116 |
| A | THR117 |
| A | THR118 |
| A | LYS159 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 301 |
| Chain | Residue |
| B | ILE36 |
| B | GLY40 |
| B | ASP110 |
| B | GLU111 |
| B | HOH2044 |
| B | HOH2106 |
| B | HOH2201 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 1219 |
| Chain | Residue |
| B | ARG60 |
| B | LYS104 |
| B | HOH2036 |
| B | HOH2197 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 5GP B 1220 |
| Chain | Residue |
| B | ASP114 |
| B | THR115 |
| B | ARG116 |
| B | THR117 |
| B | THR118 |
| B | LYS159 |
| B | TRP188 |
| B | TYR189 |
| B | TYR191 |
| B | GLU194 |
| B | HOH2106 |
| B | HOH2107 |
| B | HOH2198 |
| B | HOH2199 |
| B | HOH2200 |
| B | HOH2201 |
| B | HOH2202 |
| B | HOH2204 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP114 | |
| B | ASP114 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18245832 |
| Chain | Residue | Details |
| A | LYS85 | |
| A | ASP110 | |
| A | LYS159 | |
| A | TRP188 | |
| B | LYS85 | |
| B | ASP110 | |
| B | LYS159 | |
| B | TRP188 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
