2V7A
Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 13 |
| 詳細 | BINDING SITE FOR RESIDUE 627 A 1504 |
| 鎖名 | 残基 |
| A | LEU248 |
| A | ARG367 |
| A | LEU370 |
| A | HOH2006 |
| A | HOH2104 |
| A | GLY250 |
| A | ALA269 |
| A | LYS271 |
| A | GLU316 |
| A | PHE317 |
| A | MET318 |
| A | THR319 |
| A | GLY321 |
| site_id | AC2 |
| 残基数 | 13 |
| 詳細 | BINDING SITE FOR RESIDUE 627 B 1504 |
| 鎖名 | 残基 |
| B | LEU248 |
| B | GLY250 |
| B | ALA269 |
| B | LYS271 |
| B | GLU316 |
| B | PHE317 |
| B | MET318 |
| B | THR319 |
| B | GLY321 |
| B | ARG367 |
| B | LEU370 |
| B | ASP381 |
| B | HOH2062 |
| site_id | AC3 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE MG A 1505 |
| 鎖名 | 残基 |
| A | ASN368 |
| A | ASP381 |
| A | HOH2054 |
| site_id | AC4 |
| 残基数 | 2 |
| 詳細 | BINDING SITE FOR RESIDUE MG B 1505 |
| 鎖名 | 残基 |
| B | ASN368 |
| B | ASP381 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 2 |
| 詳細 | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
| 鎖名 | 残基 | 詳細 |
| A | ASP363 | |
| B | ASP363 |
| site_id | SWS_FT_FI2 |
| 残基数 | 6 |
| 詳細 | BINDING: |
| 鎖名 | 残基 | 詳細 |
| A | LEU248 | |
| A | LYS271 | |
| A | GLU316 | |
| B | LEU248 | |
| B | LYS271 | |
| B | GLU316 |
| site_id | SWS_FT_FI3 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P42684 |
| 鎖名 | 残基 | 詳細 |
| A | SER229 | |
| B | SER229 |
| site_id | SWS_FT_FI4 |
| 残基数 | 6 |
| 詳細 | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163 |
| 鎖名 | 残基 | 詳細 |
| A | TYR253 | |
| A | TYR257 | |
| A | TYR413 | |
| B | TYR253 | |
| B | TYR257 | |
| B | TYR413 |
| site_id | SWS_FT_FI5 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036 |
| 鎖名 | 残基 | 詳細 |
| A | PTR393 | |
| B | PTR393 |
| site_id | SWS_FT_FI6 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00520 |
| 鎖名 | 残基 | 詳細 |
| A | SER446 | |
| B | SER446 |
