2V12

Crystal Structure of Renin with Inhibitor 8

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0006508	biological_process	proteolysis
O	0004190	molecular_function	aspartic-type endopeptidase activity
O	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE C39 C 350

Chain	Residue
C	THR18
C	SER84
C	THR85
C	ALA122
C	PHE124
C	VAL127
C	GLN135
C	ASP226
C	THR227
C	GLY228
C	ALA229
C	TYR20
C	ASP38
C	GLY40
C	SER41
C	SER42
C	ASN43
C	ARG82
C	TYR83

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE C39 O 350

Chain	Residue
O	GLN19
O	TYR20
O	VAL36
O	ASP38
O	GLY40
O	SER41
O	ARG82
O	SER84
O	THR85
O	PRO118
O	ALA122
O	VAL127
O	ASP226
O	THR227
O	GLY228
O	ALA229

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV

Chain	Residue	Details
C	VAL35-VAL46
C	ALA223-GLY234

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:20927107

Chain	Residue	Details
C	ASP38
C	ASP226
O	ASP38
O	ASP226

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678

Chain	Residue	Details
C	ASN5
C	ASN75
O	ASN5
O	ASN75

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