2V0C
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE In the synthetic site and an adduct of AMP with 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) in the editing site
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004823 | molecular_function | leucine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006429 | biological_process | leucyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 8 |
| 詳細 | BINDING SITE FOR RESIDUE LEU A1501 |
| 鎖名 | 残基 |
| A | PHE41 |
| A | TYR43 |
| A | ASP80 |
| A | TYR535 |
| A | HIS541 |
| A | HIS545 |
| A | LMS1814 |
| A | HOH2474 |
| site_id | AC2 |
| 残基数 | 20 |
| 詳細 | BINDING SITE FOR RESIDUE LMS A1814 |
| 鎖名 | 残基 |
| A | PHE41 |
| A | PRO42 |
| A | TYR43 |
| A | HIS49 |
| A | GLY51 |
| A | HIS52 |
| A | ASN55 |
| A | TYR56 |
| A | GLY537 |
| A | GLY538 |
| A | GLU540 |
| A | GLN574 |
| A | GLY575 |
| A | MET576 |
| A | VAL577 |
| A | MET638 |
| A | LEU1501 |
| A | HOH2544 |
| A | HOH2678 |
| A | MET40 |
| site_id | AC3 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN A1815 |
| 鎖名 | 残基 |
| A | CYS439 |
| A | CYS442 |
| A | CYS484 |
| A | CYS487 |
| site_id | AC4 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN A1816 |
| 鎖名 | 残基 |
| A | CYS159 |
| A | CYS162 |
| A | CYS176 |
| A | HIS179 |
| site_id | AC5 |
| 残基数 | 18 |
| 詳細 | BINDING SITE FOR RESIDUE ANZ A1817 |
| 鎖名 | 残基 |
| A | PHE246 |
| A | THR247 |
| A | THR248 |
| A | ARG249 |
| A | THR252 |
| A | TYR327 |
| A | VAL328 |
| A | LEU329 |
| A | TYR332 |
| A | ILE337 |
| A | MET338 |
| A | HIS343 |
| A | ASP344 |
| A | ARG346 |
| A | HOH2335 |
| A | HOH2681 |
| A | HOH2682 |
| A | HOH2683 |
| site_id | AC6 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A1818 |
| 鎖名 | 残基 |
| A | GLU715 |
| A | GLY716 |
| A | ARG719 |
| A | LYS760 |
| A | HOH2609 |
| site_id | AC7 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A1819 |
| 鎖名 | 残基 |
| A | GLY707 |
| A | ARG769 |
| A | ARG773 |
| A | TRP795 |
| site_id | AC8 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A1820 |
| 鎖名 | 残基 |
| A | LEU207 |
| A | GLU208 |
| A | GLU214 |
| A | LYS217 |
| A | ARG221 |
| site_id | AC9 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A1821 |
| 鎖名 | 残基 |
| A | GLU301 |
| A | LYS302 |
| A | LYS353 |
| site_id | BC1 |
| 残基数 | 2 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A1822 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS00178 |
| 残基数 | 12 |
| 詳細 | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PypSGdLHMGHL |
