Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2QJG

M. jannaschii ADH synthase complexed with F1,6P

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016744	molecular_function	transketolase or transaldolase activity
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
B	0003824	molecular_function	catalytic activity
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016744	molecular_function	transketolase or transaldolase activity
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
C	0003824	molecular_function	catalytic activity
C	0004332	molecular_function	fructose-bisphosphate aldolase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016744	molecular_function	transketolase or transaldolase activity
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
D	0003824	molecular_function	catalytic activity
D	0004332	molecular_function	fructose-bisphosphate aldolase activity
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016744	molecular_function	transketolase or transaldolase activity
D	0016829	molecular_function	lyase activity
D	0016836	molecular_function	hydro-lyase activity
E	0003824	molecular_function	catalytic activity
E	0004332	molecular_function	fructose-bisphosphate aldolase activity
E	0008652	biological_process	amino acid biosynthetic process
E	0009073	biological_process	aromatic amino acid family biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016744	molecular_function	transketolase or transaldolase activity
E	0016829	molecular_function	lyase activity
E	0016836	molecular_function	hydro-lyase activity
F	0003824	molecular_function	catalytic activity
F	0004332	molecular_function	fructose-bisphosphate aldolase activity
F	0008652	biological_process	amino acid biosynthetic process
F	0009073	biological_process	aromatic amino acid family biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016744	molecular_function	transketolase or transaldolase activity
F	0016829	molecular_function	lyase activity
F	0016836	molecular_function	hydro-lyase activity
G	0003824	molecular_function	catalytic activity
G	0004332	molecular_function	fructose-bisphosphate aldolase activity
G	0008652	biological_process	amino acid biosynthetic process
G	0009073	biological_process	aromatic amino acid family biosynthetic process
G	0016740	molecular_function	transferase activity
G	0016744	molecular_function	transketolase or transaldolase activity
G	0016829	molecular_function	lyase activity
G	0016836	molecular_function	hydro-lyase activity
H	0003824	molecular_function	catalytic activity
H	0004332	molecular_function	fructose-bisphosphate aldolase activity
H	0008652	biological_process	amino acid biosynthetic process
H	0009073	biological_process	aromatic amino acid family biosynthetic process
H	0016740	molecular_function	transferase activity
H	0016744	molecular_function	transketolase or transaldolase activity
H	0016829	molecular_function	lyase activity
H	0016836	molecular_function	hydro-lyase activity
I	0003824	molecular_function	catalytic activity
I	0004332	molecular_function	fructose-bisphosphate aldolase activity
I	0008652	biological_process	amino acid biosynthetic process
I	0009073	biological_process	aromatic amino acid family biosynthetic process
I	0016740	molecular_function	transferase activity
I	0016744	molecular_function	transketolase or transaldolase activity
I	0016829	molecular_function	lyase activity
I	0016836	molecular_function	hydro-lyase activity
J	0003824	molecular_function	catalytic activity
J	0004332	molecular_function	fructose-bisphosphate aldolase activity
J	0008652	biological_process	amino acid biosynthetic process
J	0009073	biological_process	aromatic amino acid family biosynthetic process
J	0016740	molecular_function	transferase activity
J	0016744	molecular_function	transketolase or transaldolase activity
J	0016829	molecular_function	lyase activity
J	0016836	molecular_function	hydro-lyase activity
K	0003824	molecular_function	catalytic activity
K	0004332	molecular_function	fructose-bisphosphate aldolase activity
K	0008652	biological_process	amino acid biosynthetic process
K	0009073	biological_process	aromatic amino acid family biosynthetic process
K	0016740	molecular_function	transferase activity
K	0016744	molecular_function	transketolase or transaldolase activity
K	0016829	molecular_function	lyase activity
K	0016836	molecular_function	hydro-lyase activity
L	0003824	molecular_function	catalytic activity
L	0004332	molecular_function	fructose-bisphosphate aldolase activity
L	0008652	biological_process	amino acid biosynthetic process
L	0009073	biological_process	aromatic amino acid family biosynthetic process
L	0016740	molecular_function	transferase activity
L	0016744	molecular_function	transketolase or transaldolase activity
L	0016829	molecular_function	lyase activity
L	0016836	molecular_function	hydro-lyase activity
M	0003824	molecular_function	catalytic activity
M	0004332	molecular_function	fructose-bisphosphate aldolase activity
M	0008652	biological_process	amino acid biosynthetic process
M	0009073	biological_process	aromatic amino acid family biosynthetic process
M	0016740	molecular_function	transferase activity
M	0016744	molecular_function	transketolase or transaldolase activity
M	0016829	molecular_function	lyase activity
M	0016836	molecular_function	hydro-lyase activity
N	0003824	molecular_function	catalytic activity
N	0004332	molecular_function	fructose-bisphosphate aldolase activity
N	0008652	biological_process	amino acid biosynthetic process
N	0009073	biological_process	aromatic amino acid family biosynthetic process
N	0016740	molecular_function	transferase activity
N	0016744	molecular_function	transketolase or transaldolase activity
N	0016829	molecular_function	lyase activity
N	0016836	molecular_function	hydro-lyase activity
O	0003824	molecular_function	catalytic activity
O	0004332	molecular_function	fructose-bisphosphate aldolase activity
O	0008652	biological_process	amino acid biosynthetic process
O	0009073	biological_process	aromatic amino acid family biosynthetic process
O	0016740	molecular_function	transferase activity
O	0016744	molecular_function	transketolase or transaldolase activity
O	0016829	molecular_function	lyase activity
O	0016836	molecular_function	hydro-lyase activity
P	0003824	molecular_function	catalytic activity
P	0004332	molecular_function	fructose-bisphosphate aldolase activity
P	0008652	biological_process	amino acid biosynthetic process
P	0009073	biological_process	aromatic amino acid family biosynthetic process
P	0016740	molecular_function	transferase activity
P	0016744	molecular_function	transketolase or transaldolase activity
P	0016829	molecular_function	lyase activity
P	0016836	molecular_function	hydro-lyase activity
Q	0003824	molecular_function	catalytic activity
Q	0004332	molecular_function	fructose-bisphosphate aldolase activity
Q	0008652	biological_process	amino acid biosynthetic process
Q	0009073	biological_process	aromatic amino acid family biosynthetic process
Q	0016740	molecular_function	transferase activity
Q	0016744	molecular_function	transketolase or transaldolase activity
Q	0016829	molecular_function	lyase activity
Q	0016836	molecular_function	hydro-lyase activity
R	0003824	molecular_function	catalytic activity
R	0004332	molecular_function	fructose-bisphosphate aldolase activity
R	0008652	biological_process	amino acid biosynthetic process
R	0009073	biological_process	aromatic amino acid family biosynthetic process
R	0016740	molecular_function	transferase activity
R	0016744	molecular_function	transketolase or transaldolase activity
R	0016829	molecular_function	lyase activity
R	0016836	molecular_function	hydro-lyase activity
S	0003824	molecular_function	catalytic activity
S	0004332	molecular_function	fructose-bisphosphate aldolase activity
S	0008652	biological_process	amino acid biosynthetic process
S	0009073	biological_process	aromatic amino acid family biosynthetic process
S	0016740	molecular_function	transferase activity
S	0016744	molecular_function	transketolase or transaldolase activity
S	0016829	molecular_function	lyase activity
S	0016836	molecular_function	hydro-lyase activity
T	0003824	molecular_function	catalytic activity
T	0004332	molecular_function	fructose-bisphosphate aldolase activity
T	0008652	biological_process	amino acid biosynthetic process
T	0009073	biological_process	aromatic amino acid family biosynthetic process
T	0016740	molecular_function	transferase activity
T	0016744	molecular_function	transketolase or transaldolase activity
T	0016829	molecular_function	lyase activity
T	0016836	molecular_function	hydro-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE F2P A 501

Chain	Residue
A	ASP33
A	LYS184
A	GLY209
A	GLY210
A	ALA235
A	VAL236
A	GLY237
A	ARG238
A	HIS34
A	SER37
A	ASN38
A	LYS99
A	HIS119
A	MET151
A	TYR153
A	ARG155

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE F2P B 501

Chain	Residue
B	PRO31
B	ASP33
B	HIS34
B	SER37
B	ASN38
B	MET151
B	TYR153
B	ARG155
B	LYS184
B	ALA208
B	GLY209
B	GLY210
B	ALA235
B	VAL236
B	GLY237
B	ARG238
B	HOH516
B	HOH526

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE F2P C 501

Chain	Residue
C	ASP33
C	HIS34
C	SER37
C	TYR153
C	ARG155
C	LYS184
C	GLY209
C	GLY210
C	ALA235
C	VAL236
C	GLY237
C	ARG238
C	HOH503
C	HOH513

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE F2P D 501

Chain	Residue
D	PRO31
D	ASP33
D	HIS34
D	SER37
D	LYS99
D	HIS119
D	MET151
D	TYR153
D	ARG155
D	LYS184
D	GLY209
D	GLY210
D	ALA235
D	GLY237
D	ARG238

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE F2P E 501

Chain	Residue
E	ASP33
E	HIS34
E	SER37
E	ASN38
E	MET151
E	TYR153
E	ARG155
E	LYS184
E	GLY209
E	GLY210
E	VAL236
E	GLY237
E	ARG238

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE F2P K 501

Chain	Residue
K	PRO31
K	ASP33
K	HIS34
K	SER37
K	LYS99
K	HIS119
K	MET151
K	TYR153
K	ARG155
K	LYS184
K	GLY209
K	GLY210
K	ALA235
K	VAL236
K	GLY237
K	ARG238

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE F2P L 501

Chain	Residue
L	TYR153
L	ARG155
L	LYS184
L	ALA208
L	GLY209
L	GLY210
L	ALA235
L	VAL236
L	GLY237
L	ARG238
L	PRO31
L	ASP33
L	HIS34
L	SER37
L	ASN38
L	HIS119
L	MET151

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE F2P M 501

Chain	Residue
M	PRO31
M	ASP33
M	HIS34
M	SER37
M	ASN38
M	LYS99
M	HIS119
M	MET151
M	TYR153
M	ARG155
M	LYS184
M	GLY209
M	GLY210
M	VAL236
M	GLY237
M	ARG238

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE F2P N 501

Chain	Residue
N	PRO31
N	ASP33
N	HIS34
N	SER37
N	LYS99
N	HIS119
N	MET151
N	TYR153
N	ARG155
N	LYS184
N	GLY209
N	GLY210
N	VAL236
N	GLY237
N	ARG238
N	HOH504

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE F2P O 501

Chain	Residue
O	PRO31
O	ASP33
O	HIS34
O	SER37
O	HIS119
O	MET151
O	TYR153
O	LYS184
O	ALA208
O	GLY209
O	GLY210
O	VAL236
O	GLY237
O	ARG238

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE F2P F 501

Chain	Residue
F	PRO31
F	ASP33
F	HIS34
F	HIS119
F	MET151
F	TYR153
F	ARG155
F	LYS184
F	ALA208
F	GLY209
F	GLY210
F	ALA235
F	VAL236
F	GLY237
F	ARG238

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE F2P G 501

Chain	Residue
G	PRO31
G	ASP33
G	HIS34
G	SER37
G	ASN38
G	MET151
G	TYR153
G	LYS184
G	GLY209
G	GLY210
G	ALA235
G	VAL236
G	GLY237
G	ARG238

site_id	BC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE F2P H 501

Chain	Residue
H	PRO31
H	ASP33
H	HIS34
H	SER37
H	ASN38
H	HIS119
H	TYR153
H	ARG155
H	LYS184
H	ALA208
H	GLY209
H	GLY210
H	ALA235
H	VAL236
H	GLY237
H	ARG238
H	HOH504
H	HOH508

site_id	BC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE F2P I 501

Chain	Residue
I	PRO31
I	ASP33
I	HIS34
I	SER37
I	ASN38
I	HIS119
I	MET151
I	TYR153
I	ARG155
I	LYS184
I	GLY209
I	GLY210
I	VAL236
I	GLY237
I	ARG238
I	HOH517

site_id	BC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE F2P J 501

Chain	Residue
J	ASP33
J	HIS34
J	SER37
J	ASN38
J	LYS99
J	MET151
J	TYR153
J	LYS184
J	GLY209
J	GLY210
J	ALA235
J	VAL236
J	GLY237
J	ARG238
J	HOH504

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE F2P P 501

Chain	Residue
P	PRO31
P	ASP33
P	HIS34
P	SER37
P	ASN38
P	HIS119
P	MET151
P	TYR153
P	ARG155
P	LYS184
P	GLY209
P	GLY210
P	VAL236
P	GLY237
P	ARG238

site_id	BC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE F2P Q 501

Chain	Residue
Q	ASP33
Q	HIS34
Q	SER37
Q	ASN38
Q	MET151
Q	TYR153
Q	ARG155
Q	LYS184
Q	GLY209
Q	GLY210
Q	ALA235
Q	VAL236
Q	GLY237
Q	ARG238

site_id	BC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE F2P R 501

Chain	Residue
R	PRO31
R	ASP33
R	HIS34
R	SER37
R	ASN38
R	MET151
R	TYR153
R	ARG155
R	LYS184
R	GLY209
R	GLY210
R	ALA235
R	VAL236
R	GLY237
R	ARG238

site_id	CC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE F2P S 501

Chain	Residue
S	ASP33
S	HIS34
S	SER37
S	ASN38
S	LYS99
S	MET151
S	TYR153
S	ARG155
S	LYS184
S	GLY209
S	GLY210
S	ALA235
S	VAL236
S	GLY237
S	ARG238

site_id	CC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE F2P T 501

Chain	Residue
T	PRO31
T	ASP33
T	HIS34
T	SER37
T	LYS99
T	HIS119
T	MET151
T	TYR153
T	ARG155
T	LYS184
T	GLY209
T	GLY210
T	ALA235
T	VAL236
T	GLY237
T	ARG238
T	HOH517
T	HOH521
T	HOH525

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:17713928

Chain	Residue	Details
A	ASP33
O	ASP33
F	ASP33
G	ASP33
H	ASP33
I	ASP33
J	ASP33
P	ASP33
Q	ASP33
R	ASP33
S	ASP33
B	ASP33
T	ASP33
C	ASP33
D	ASP33
E	ASP33
K	ASP33
L	ASP33
M	ASP33
N	ASP33

site_id	SWS_FT_FI2
Number of Residues	20
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:17713928

Chain	Residue	Details
A	TYR153
O	TYR153
F	TYR153
G	TYR153
H	TYR153
I	TYR153
J	TYR153
P	TYR153
Q	TYR153
R	TYR153
S	TYR153
B	TYR153
T	TYR153
C	TYR153
D	TYR153
E	TYR153
K	TYR153
L	TYR153
M	TYR153
N	TYR153

site_id	SWS_FT_FI3
Number of Residues	20
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000305\|PubMed:17713928

Chain	Residue	Details
A	LYS184
O	LYS184
F	LYS184
G	LYS184
H	LYS184
I	LYS184
J	LYS184
P	LYS184
Q	LYS184
R	LYS184
S	LYS184
B	LYS184
T	LYS184
C	LYS184
D	LYS184
E	LYS184
K	LYS184
L	LYS184
M	LYS184
N	LYS184

site_id	SWS_FT_FI4
Number of Residues	80
Details	BINDING: BINDING => ECO:0000305\|PubMed:17713928

Chain	Residue	Details
A	ASP33
C	TYR153
C	GLY209
C	GLY237
D	ASP33
D	TYR153
D	GLY209
D	GLY237
E	ASP33
E	TYR153
E	GLY209
A	TYR153
E	GLY237
K	ASP33
K	TYR153
K	GLY209
K	GLY237
L	ASP33
L	TYR153
L	GLY209
L	GLY237
M	ASP33
A	GLY209
M	TYR153
M	GLY209
M	GLY237
N	ASP33
N	TYR153
N	GLY209
N	GLY237
O	ASP33
O	TYR153
O	GLY209
A	GLY237
O	GLY237
F	ASP33
F	TYR153
F	GLY209
F	GLY237
G	ASP33
G	TYR153
G	GLY209
G	GLY237
H	ASP33
B	ASP33
H	TYR153
H	GLY209
H	GLY237
I	ASP33
I	TYR153
I	GLY209
I	GLY237
J	ASP33
J	TYR153
J	GLY209
B	TYR153
J	GLY237
P	ASP33
P	TYR153
P	GLY209
P	GLY237
Q	ASP33
Q	TYR153
Q	GLY209
Q	GLY237
R	ASP33
B	GLY209
R	TYR153
R	GLY209
R	GLY237
S	ASP33
S	TYR153
S	GLY209
S	GLY237
T	ASP33
T	TYR153
T	GLY209
B	GLY237
T	GLY237
C	ASP33

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)