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2NVU

Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0004839molecular_functionubiquitin activating enzyme activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006511biological_processubiquitin-dependent protein catabolic process
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007049biological_processcell cycle
A0007165biological_processsignal transduction
A0008641molecular_functionubiquitin-like modifier activating enzyme activity
A0016020cellular_componentmembrane
A0016567biological_processprotein ubiquitination
A0019781molecular_functionNEDD8 activating enzyme activity
A0031625molecular_functionubiquitin protein ligase binding
A0032991cellular_componentprotein-containing complex
A0033314biological_processmitotic DNA replication checkpoint signaling
A0042981biological_processregulation of apoptotic process
A0043523biological_processregulation of neuron apoptotic process
A0045116biological_processprotein neddylation
A0046982molecular_functionprotein heterodimerization activity
A0051402biological_processneuron apoptotic process
B0000166molecular_functionnucleotide binding
B0000278biological_processmitotic cell cycle
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0007049biological_processcell cycle
B0007113biological_processendomitotic cell cycle
B0008641molecular_functionubiquitin-like modifier activating enzyme activity
B0008643biological_processcarbohydrate transport
B0015144molecular_functioncarbohydrate transmembrane transporter activity
B0016874molecular_functionligase activity
B0019781molecular_functionNEDD8 activating enzyme activity
B0019788molecular_functionNEDD8 transferase activity
B0032991cellular_componentprotein-containing complex
B0036211biological_processprotein modification process
B0042802molecular_functionidentical protein binding
B0043687biological_processpost-translational protein modification
B0045116biological_processprotein neddylation
B0046982molecular_functionprotein heterodimerization activity
B0051726biological_processregulation of cell cycle
B0055085biological_processtransmembrane transport
C0000166molecular_functionnucleotide binding
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005829cellular_componentcytosol
C0016740molecular_functiontransferase activity
C0019788molecular_functionNEDD8 transferase activity
C0036211biological_processprotein modification process
C0043525biological_processpositive regulation of neuron apoptotic process
C0043687biological_processpost-translational protein modification
C0045116biological_processprotein neddylation
C0061654molecular_functionNEDD8 conjugating enzyme activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006357biological_processregulation of transcription by RNA polymerase II
I0006508biological_processproteolysis
I0006511biological_processubiquitin-dependent protein catabolic process
I0008104biological_processprotein localization
I0009653biological_processanatomical structure morphogenesis
I0016567biological_processprotein ubiquitination
I0019941biological_processmodification-dependent protein catabolic process
I0030162biological_processregulation of proteolysis
I0031386molecular_functionprotein tag activity
I0031625molecular_functionubiquitin protein ligase binding
I0036211biological_processprotein modification process
I0045116biological_processprotein neddylation
I0070062cellular_componentextracellular exosome
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006357biological_processregulation of transcription by RNA polymerase II
J0006508biological_processproteolysis
J0006511biological_processubiquitin-dependent protein catabolic process
J0008104biological_processprotein localization
J0009653biological_processanatomical structure morphogenesis
J0016567biological_processprotein ubiquitination
J0019941biological_processmodification-dependent protein catabolic process
J0030162biological_processregulation of proteolysis
J0031386molecular_functionprotein tag activity
J0031625molecular_functionubiquitin protein ligase binding
J0036211biological_processprotein modification process
J0045116biological_processprotein neddylation
J0070062cellular_componentextracellular exosome
PDBデータベースに由来する情報
site_idAC1
残基数3
詳細BINDING SITE FOR RESIDUE MG B 101
鎖名残基
BHOH45
BATP103
BASP2146

site_idAC2
残基数4
詳細BINDING SITE FOR RESIDUE ZN B 102
鎖名残基
BCYS2199
BCYS2202
BCYS2343
BCYS2346

site_idAC3
残基数22
詳細BINDING SITE FOR RESIDUE ATP B 103
鎖名残基
BHOH31
BHOH40
BHOH45
BMG101
BALA2056
BGLY2057
BASP2079
BMET2080
BASP2081
BASN2087
BARG2090
BGLN2091
BLYS2103
BASN2125
BLYS2126
BILE2127
BGLN2128
BGLY2144
BASP2146
IGLY76
AARG15
BHOH5

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00299
残基数26
詳細UBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD
鎖名残基詳細
ILYS27-ASP52

site_idPS00865
残基数9
詳細UBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PMCTIAsMP
鎖名残基詳細
BPRO2214-PRO2222

site_idPS01037
残基数18
詳細SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
鎖名残基詳細
BPRO1108-ASN1125

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数4
詳細SITE: Interaction with UBE1C => ECO:0000269|PubMed:14690597
鎖名残基詳細
ILEU8
IILE44
JLEU8
JILE44

site_idSWS_FT_FI2
残基数2
詳細MOD_RES: (Microbial infection) Deamidated glutamine => ECO:0000269|PubMed:20688984, ECO:0000269|PubMed:21903097, ECO:0000269|PubMed:23175788, ECO:0000269|PubMed:23589306, ECO:0000269|PubMed:26632597
鎖名残基詳細
IGLN40
JGLN40

site_idSWS_FT_FI3
残基数2
詳細MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P29595
鎖名残基詳細
ILYS48
JLYS48

site_idSWS_FT_FI4
残基数4
詳細CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
鎖名残基詳細
IGLY76
JGLY76

site_idSWS_FT_FI5
残基数1
詳細MOD_RES: Omega-N-methylarginine; alternate => ECO:0007744|PubMed:24129315
鎖名残基詳細
CGLY174

218500

件を2024-04-17に公開中

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