2M4Z
Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin, Huwentoxin-IV (-TRTX-Hh2a).
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | SITE: Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503 |
| Chain | Residue | Details |
| A | PHE6 | |
| A | ARG26 | |
| A | LYS27 | |
| A | ALA30 | |
| A | LYS32 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid (Glu); partial => ECO:0000269|PubMed:23826086 |
| Chain | Residue | Details |
| A | GLU1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Isoleucine amide => ECO:0000269|PubMed:12228241 |
| Chain | Residue | Details |
| A | ILE35 |
