2JZW

How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 56

Chain	Residue
A	CYS15
A	CYS18
A	HIS23

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 57

Chain	Residue
A	CYS36
A	CYS39
A	LYS41
A	HIS44
A	GLN45

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	ZN_FING: CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047

Chain	Residue	Details
A	VAL13-ALA30

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site_id	SWS_FT_FI2
Number of Residues	17
Details	ZN_FING: CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047

Chain	Residue	Details
A	LYS34-GLU51

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000255

Chain	Residue	Details
A	ASN55

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Asymmetric dimethylarginine; in Nucleocapsid protein p7; by host PRMT6 => ECO:0000269|PubMed:17415034

Chain	Residue	Details
A	ARG32

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