2JIF

Structure of human short-branched chain acyl-CoA dehydrogenase (ACADSB)

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0003995	molecular_function	acyl-CoA dehydrogenase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0003995	molecular_function	acyl-CoA dehydrogenase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0050660	molecular_function	flavin adenine dinucleotide binding
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0050660	molecular_function	flavin adenine dinucleotide binding
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0050660	molecular_function	flavin adenine dinucleotide binding

PDBデータベースに由来する情報

site_id	AC1
残基数	2
詳細	BINDING SITE FOR RESIDUE CL A1436

鎖名	残基
A	ASP108
A	ARG151

---

site_id	AC2
残基数	2
詳細	BINDING SITE FOR RESIDUE CL A1437

鎖名	残基
A	HIS213
A	SER259

---

site_id	AC3
残基数	2
詳細	BINDING SITE FOR RESIDUE CL B1436

鎖名	残基
B	ASP108
B	ARG151

---

site_id	AC4
残基数	2
詳細	BINDING SITE FOR RESIDUE CL B1437

鎖名	残基
B	HIS213
B	SER259

---

site_id	AC5
残基数	2
詳細	BINDING SITE FOR RESIDUE CL B1438

鎖名	残基
B	TYR373
A	TYR373

---

site_id	AC6
残基数	2
詳細	BINDING SITE FOR RESIDUE CL C1436

鎖名	残基
C	ASP108
C	ARG151

---

site_id	AC7
残基数	2
詳細	BINDING SITE FOR RESIDUE CL C1437

鎖名	残基
C	SER259
C	HOH2141

---

site_id	AC8
残基数	2
詳細	BINDING SITE FOR RESIDUE CL D1439

鎖名	残基
D	ASP108
D	ARG151

---

site_id	AC9
残基数	2
詳細	BINDING SITE FOR RESIDUE CL D1440

鎖名	残基
D	HIS213
D	SER259

---

site_id	BC1
残基数	2
詳細	BINDING SITE FOR RESIDUE CL D1441

鎖名	残基
C	TYR373
D	TYR373

---

site_id	BC2
残基数	32
詳細	BINDING SITE FOR RESIDUE FAD A1433

鎖名	残基
A	PHE174
A	LEU176
A	SER177
A	GLY182
A	SER183
A	TRP207
A	SER209
A	THR260
A	ILE409
A	ILE412
A	ALA416
A	ASN418
A	ILE419
A	ASN422
A	COS1434
A	HOH2182
A	HOH2195
A	HOH2196
A	HOH2197
A	HOH2198
A	HOH2199
B	GLN330
C	ARG319
C	GLN321
C	PHE322
C	LEU326
C	PHE329
C	LEU332
C	GLU387
C	TRP388
C	GLY391
C	HOH2203

---

site_id	BC3
残基数	19
詳細	BINDING SITE FOR RESIDUE COS A1434

鎖名	残基
A	SER183
A	SER185
A	TYR229
A	LYS230
A	TYR283
A	ILE287
A	LEU290
A	ASN291
A	ARG294
A	TYR413
A	GLU414
A	GLY415
A	ILE419
A	FAD1433
A	HOH2062
A	HOH2185
A	HOH2201
A	HOH2202
C	PHE322

---

site_id	BC4
残基数	5
詳細	BINDING SITE FOR RESIDUE EDO A1435

鎖名	残基
A	VAL131
A	PRO399
A	TYR403
A	HOH2203
A	HOH2204

---

site_id	BC5
残基数	33
詳細	BINDING SITE FOR RESIDUE FAD B1433

鎖名	残基
D	ARG319
D	GLN321
D	PHE322
D	LEU326
D	PHE329
D	LEU332
D	GLU387
D	TRP388
D	GLY391
D	HOH2227
A	GLN330
B	PHE174
B	LEU176
B	SER177
B	GLY182
B	SER183
B	TRP207
B	SER209
B	LYS252
B	THR260
B	ILE409
B	ILE412
B	ALA416
B	ASN418
B	ASN422
B	COS1434
B	HOH2181
B	HOH2193
B	HOH2194
B	HOH2195
B	HOH2196
B	HOH2197
B	HOH2198

---

site_id	BC6
残基数	18
詳細	BINDING SITE FOR RESIDUE COS B1434

鎖名	残基
B	SER183
B	SER185
B	PHE186
B	TYR229
B	TYR283
B	ILE287
B	LEU290
B	ASN291
B	ARG294
B	TYR413
B	GLU414
B	GLY415
B	ILE419
B	FAD1433
B	HOH2200
B	HOH2201
B	HOH2202
D	PHE322

---

site_id	BC7
残基数	6
詳細	BINDING SITE FOR RESIDUE EDO B1435

鎖名	残基
B	ARG256
B	HOH2203
B	HOH2204
D	ARG256
D	HOH2030
D	HOH2231

---

site_id	BC8
残基数	31
詳細	BINDING SITE FOR RESIDUE FAD C1433

鎖名	残基
A	ARG319
A	GLN321
A	PHE322
A	LEU326
A	PHE329
A	LEU332
A	GLU387
A	TRP388
A	GLY391
A	HOH2166
C	PHE174
C	LEU176
C	SER177
C	GLY182
C	SER183
C	TRP207
C	SER209
C	THR260
C	ILE409
C	ILE412
C	ALA416
C	ASN418
C	ASN422
C	COS1434
C	HOH2113
C	HOH2226
C	HOH2227
C	HOH2228
C	HOH2229
C	HOH2230
D	GLN330

---

site_id	BC9
残基数	21
詳細	BINDING SITE FOR RESIDUE COS C1434

鎖名	残基
C	SER183
C	SER185
C	PHE186
C	TYR229
C	LYS230
C	TYR283
C	ILE287
C	ASN291
C	ARG294
C	TYR413
C	GLU414
C	GLY415
C	ILE419
C	FAD1433
C	HOH2089
C	HOH2220
C	HOH2221
C	HOH2231
C	HOH2232
C	HOH2233
C	HOH2234

---

site_id	CC1
残基数	5
詳細	BINDING SITE FOR RESIDUE EDO C1435

鎖名	残基
C	VAL131
C	PRO399
C	TYR403
C	HOH2235
C	HOH2236

---

site_id	CC2
残基数	32
詳細	BINDING SITE FOR RESIDUE FAD D1433

鎖名	残基
B	ARG319
B	PHE322
B	LEU326
B	PHE329
B	LEU332
B	GLU387
B	TRP388
B	GLY391
B	HOH2165
C	GLN330
D	PHE174
D	LEU176
D	SER177
D	GLY182
D	SER183
D	TRP207
D	ILE208
D	SER209
D	ILE409
D	ILE412
D	ALA416
D	ASN418
D	ILE419
D	ASN422
D	COS1434
D	HOH2241
D	HOH2243
D	HOH2255
D	HOH2256
D	HOH2257
D	HOH2258
D	HOH2259

---

site_id	CC3
残基数	23
詳細	BINDING SITE FOR RESIDUE COS D1434

鎖名	残基
D	SER183
D	SER185
D	PHE186
D	TYR229
D	TYR283
D	ILE287
D	LEU290
D	ASN291
D	ARG294
D	ILE364
D	TYR413
D	GLU414
D	GLY415
D	ILE419
D	FAD1433
D	EDO1437
D	HOH2097
D	HOH2261
D	HOH2262
D	HOH2263
D	HOH2264
D	HOH2265
D	HOH2267

---

site_id	CC4
残基数	6
詳細	BINDING SITE FOR RESIDUE EDO D1435

鎖名	残基
C	LYS88
D	GLN158
D	TYR162
D	LEU236
D	ALA273
D	ASN274

---

site_id	CC5
残基数	5
詳細	BINDING SITE FOR RESIDUE EDO D1436

鎖名	残基
C	LYS91
D	VAL237
D	ASP238
D	THR241
D	ASN274

---

site_id	CC6
残基数	5
詳細	BINDING SITE FOR RESIDUE EDO D1437

鎖名	残基
B	PHE322
D	ILE419
D	ASN422
D	COS1434
D	HOH2267

---

site_id	CC7
残基数	4
詳細	BINDING SITE FOR RESIDUE EDO D1438

鎖名	残基
D	VAL131
D	PRO399
D	TYR403
D	HOH2269

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00072
残基数	13
詳細	ACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. CLSEagAGSDsfA

鎖名	残基	詳細
A	CYS175-ALA187

---

site_id	PS00073
残基数	20
詳細	ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. EwMGGvGYtkDypveKyfrD

鎖名	残基	詳細
A	GLU387-ASP406

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	4
詳細	ACT_SITE: Proton acceptor => ECO:0000305|Ref.15

鎖名	残基	詳細
A	GLU414
B	GLU414
C	GLU414
D	GLU414

---

site_id	SWS_FT_FI2
残基数	12
詳細	BINDING: in other chain => ECO:0000269|Ref.15

鎖名	残基	詳細
A	PHE174
D	PHE174
D	TRP207
D	ALA416
A	TRP207
A	ALA416
B	PHE174
B	TRP207
B	ALA416
C	PHE174
C	TRP207
C	ALA416

---

site_id	SWS_FT_FI3
残基数	28
詳細	BINDING: BINDING => ECO:0000269|Ref.15

鎖名	残基	詳細
A	SER183
B	TYR283
B	ASN291
B	ARG319
B	GLN330
B	GLU387
C	SER183
C	TYR229
C	TYR283
C	ASN291
C	ARG319
A	TYR229
C	GLN330
C	GLU387
D	SER183
D	TYR229
D	TYR283
D	ASN291
D	ARG319
D	GLN330
D	GLU387
A	TYR283
A	ASN291
A	ARG319
A	GLN330
A	GLU387
B	SER183
B	TYR229

---

site_id	SWS_FT_FI4
残基数	8
詳細	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DBL1

鎖名	残基	詳細
A	LYS70
A	LYS284
B	LYS70
B	LYS284
C	LYS70
C	LYS284
D	LYS70
D	LYS284

---

site_id	SWS_FT_FI5
残基数	4
詳細	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

鎖名	残基	詳細
A	SER183
B	SER183
C	SER183
D	SER183

---

site_id	SWS_FT_FI6
残基数	4
詳細	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DBL1

鎖名	残基	詳細
A	LYS426
B	LYS426
C	LYS426
D	LYS426

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