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2HX2

Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004517molecular_functionnitric-oxide synthase activity
A0006809biological_processnitric oxide biosynthetic process
A0020037molecular_functionheme binding
B0004517molecular_functionnitric-oxide synthase activity
B0006809biological_processnitric oxide biosynthetic process
B0020037molecular_functionheme binding
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CAC A 850
ChainResidue
ATRP324
ACYS384

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 860
ChainResidue
ATRP358
AVAL420
ASER428
AHOH1125
AHOH1145

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 861
ChainResidue
AASN368
AARG374
AHOH921
AGLN249
AARG252

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CAC B 850
ChainResidue
BLYS69
BTYR83
BTRP324
BCYS384

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT B 860
ChainResidue
BGLY188
BTRP358
BVAL420
BSER428
BHOH1046

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT B 861
ChainResidue
BARG252
BASN368
BARG374
BHOH881

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 900
ChainResidue
ACYS96
ACYS101
BCYS96
BCYS101

site_idAC8
Number of Residues16
DetailsBINDING SITE FOR RESIDUE HEM A 700
ChainResidue
ATRP180
AARG185
ACYS186
AMET341
APHE355
ASER356
ATRP358
AGLU363
ATRP449
ATYR477
AH4B760
A3HX793
AHOH912
AHOH1018
AHOH1081
AHOH1169

site_idAC9
Number of Residues15
DetailsBINDING SITE FOR RESIDUE H4B A 760
ChainResidue
ASER104
AARG367
AALA448
ATRP449
AHEM700
AGOL880
AHOH906
AHOH912
AHOH918
AHOH931
BTRP447
BPHE462
BHIS463
BGLN464
BGLU465

site_idBC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 3HX A 793
ChainResidue
APRO336
AVAL338
AASN340
APHE355
ASER356
AGLY357
ATRP358
AGLU363
AHEM700
AHOH911
AHOH971
AHOH1022

site_idBC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE HEM B 700
ChainResidue
BTRP180
BARG185
BCYS186
BSER228
BPHE355
BSER356
BGLY357
BTRP358
BGLU363
BTRP449
BTYR477
BH4B760
B3HX793
BHOH886
BHOH909
BHOH1067

site_idBC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE H4B B 760
ChainResidue
BHOH915
BHOH922
BHOH949
ATRP447
APHE462
AHIS463
AGLU465
BSER104
BARG367
BALA448
BTRP449
BHEM700
BGOL880
BHOH886

site_idBC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 3HX B 793
ChainResidue
BPRO336
BVAL338
BASN340
BSER356
BGLY357
BTRP358
BGLU363
BHEM700
BHOH950
BHOH1083

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 880
ChainResidue
AVAL106
AARG367
AHIS373
AH4B760
AHOH906

site_idBC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 880
ChainResidue
ATRP76
BVAL106
BARG367
BHIS373
BTRP449
BH4B760
BHOH915
BHOH932

Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCVGRIqW
ChainResidueDetails
AARG185-TRP192

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P35228
ChainResidueDetails
ATHR97
ALEU102
BTHR97
BLEU102

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P29474
ChainResidueDetails
ALEU105
AGLN478
BLEU105
BLEU250
BTYR359
BMET360
BILE364
BLEU369
BTRP449
BILE450
BHIS463
ALEU250
BGLN478
ATYR359
AMET360
AILE364
ALEU369
ATRP449
AILE450
AHIS463

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000250|UniProtKB:P29474
ChainResidueDetails
AVAL187
BVAL187

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CDK5 => ECO:0000250|UniProtKB:P29474
ChainResidueDetails
APRO117
BPRO117

218853

数据于2024-04-24公开中

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