Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2H0R

Structure of the Yeast Nicotinamidase Pnc1p

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000183	biological_process	rDNA heterochromatin formation
A	0000781	cellular_component	chromosome, telomeric region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0008270	molecular_function	zinc ion binding
A	0008936	molecular_function	nicotinamidase activity
A	0016787	molecular_function	hydrolase activity
A	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
A	0019358	biological_process	nicotinate nucleotide salvage
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0046872	molecular_function	metal ion binding
A	1904524	biological_process	negative regulation of DNA amplification
B	0000183	biological_process	rDNA heterochromatin formation
B	0000781	cellular_component	chromosome, telomeric region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005777	cellular_component	peroxisome
B	0008270	molecular_function	zinc ion binding
B	0008936	molecular_function	nicotinamidase activity
B	0016787	molecular_function	hydrolase activity
B	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
B	0019358	biological_process	nicotinate nucleotide salvage
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0031509	biological_process	subtelomeric heterochromatin formation
B	0046872	molecular_function	metal ion binding
B	1904524	biological_process	negative regulation of DNA amplification
C	0000183	biological_process	rDNA heterochromatin formation
C	0000781	cellular_component	chromosome, telomeric region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0008270	molecular_function	zinc ion binding
C	0008936	molecular_function	nicotinamidase activity
C	0016787	molecular_function	hydrolase activity
C	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
C	0019358	biological_process	nicotinate nucleotide salvage
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0046872	molecular_function	metal ion binding
C	1904524	biological_process	negative regulation of DNA amplification
D	0000183	biological_process	rDNA heterochromatin formation
D	0000781	cellular_component	chromosome, telomeric region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005777	cellular_component	peroxisome
D	0008270	molecular_function	zinc ion binding
D	0008936	molecular_function	nicotinamidase activity
D	0016787	molecular_function	hydrolase activity
D	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
D	0019358	biological_process	nicotinate nucleotide salvage
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0031509	biological_process	subtelomeric heterochromatin formation
D	0046872	molecular_function	metal ion binding
D	1904524	biological_process	negative regulation of DNA amplification
E	0000183	biological_process	rDNA heterochromatin formation
E	0000781	cellular_component	chromosome, telomeric region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005777	cellular_component	peroxisome
E	0008270	molecular_function	zinc ion binding
E	0008936	molecular_function	nicotinamidase activity
E	0016787	molecular_function	hydrolase activity
E	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
E	0019358	biological_process	nicotinate nucleotide salvage
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0031509	biological_process	subtelomeric heterochromatin formation
E	0046872	molecular_function	metal ion binding
E	1904524	biological_process	negative regulation of DNA amplification
F	0000183	biological_process	rDNA heterochromatin formation
F	0000781	cellular_component	chromosome, telomeric region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005777	cellular_component	peroxisome
F	0008270	molecular_function	zinc ion binding
F	0008936	molecular_function	nicotinamidase activity
F	0016787	molecular_function	hydrolase activity
F	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
F	0019358	biological_process	nicotinate nucleotide salvage
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0031509	biological_process	subtelomeric heterochromatin formation
F	0046872	molecular_function	metal ion binding
F	1904524	biological_process	negative regulation of DNA amplification
G	0000183	biological_process	rDNA heterochromatin formation
G	0000781	cellular_component	chromosome, telomeric region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005777	cellular_component	peroxisome
G	0008270	molecular_function	zinc ion binding
G	0008936	molecular_function	nicotinamidase activity
G	0016787	molecular_function	hydrolase activity
G	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
G	0019358	biological_process	nicotinate nucleotide salvage
G	0019363	biological_process	pyridine nucleotide biosynthetic process
G	0031509	biological_process	subtelomeric heterochromatin formation
G	0046872	molecular_function	metal ion binding
G	1904524	biological_process	negative regulation of DNA amplification

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	ASP51
A	HIS53
A	HIS94

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 301

Chain	Residue
B	ASP51
B	HIS53
B	HIS94

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 301

Chain	Residue
C	ASP51
C	HIS53
C	HIS94

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 301

Chain	Residue
D	ASP51
D	HIS53
D	HIS94

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 301

Chain	Residue
E	ASP51
E	HIS53
E	HIS94
E	GLU129

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN F 301

Chain	Residue
F	ASP51
F	HIS53
F	HIS94

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN G 301

Chain	Residue
G	ASP51
G	HIS53
G	HIS94

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: ACT_SITE => ECO:0000255

Chain	Residue	Details
A	ASP8
A	LYS122
B	ASP8
B	LYS122
C	ASP8
C	LYS122
D	ASP8
D	LYS122
E	ASP8
E	LYS122
F	ASP8
F	LYS122
G	ASP8
G	LYS122

site_id	SWS_FT_FI2
Number of Residues	7
Details	ACT_SITE: Nucleophile => ECO:0000255

Chain	Residue	Details
A	CYS167
B	CYS167
C	CYS167
D	CYS167
E	CYS167
F	CYS167
G	CYS167

site_id	SWS_FT_FI3
Number of Residues	21
Details	BINDING: BINDING => ECO:0000269\|PubMed:17382284, ECO:0007744\|PDB:2H0R

Chain	Residue	Details
A	ASP51
A	HIS53
A	HIS94
B	ASP51
B	HIS53
B	HIS94
C	ASP51
C	HIS53
C	HIS94
D	ASP51
D	HIS53
D	HIS94
E	ASP51
E	HIS53
E	HIS94
F	ASP51
F	HIS53
F	HIS94
G	ASP51
G	HIS53
G	HIS94

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)