2GMH
Structure of Porcine Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase in Complexed with Ubiquinone
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004174 | molecular_function | electron-transferring-flavoprotein dehydrogenase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0022900 | biological_process | electron transport chain |
| A | 0022904 | biological_process | respiratory electron transport chain |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048039 | molecular_function | ubiquinone binding |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0004174 | molecular_function | electron-transferring-flavoprotein dehydrogenase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0022900 | biological_process | electron transport chain |
| B | 0022904 | biological_process | respiratory electron transport chain |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048039 | molecular_function | ubiquinone binding |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | LEU86-THR107 | |
| A | ASN405-SER424 | |
| B | LEU86-THR107 | |
| B | ASN405-SER424 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17050691 |
| Chain | Residue | Details |
| A | THR52 | |
| A | GLY282 | |
| A | GLU283 | |
| B | THR52 | |
| B | GLY282 | |
| B | GLU283 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU538 | |
| A | ASP563 | |
| A | GLN566 | |
| A | ASN569 | |
| B | LEU538 | |
| B | ASP563 | |
| B | GLN566 | |
| B | ASN569 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q921G7 |
| Chain | Residue | Details |
| A | ALA73 | |
| A | VAL109 | |
| A | ARG200 | |
| A | ASN334 | |
| B | ALA73 | |
| B | VAL109 | |
| B | ARG200 | |
| B | ASN334 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q16134 |
| Chain | Residue | Details |
| A | CYS528 | |
| B | CYS528 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 281 |
| Chain | Residue | Details |
| A | GLU92 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | ILE341 | activator, hydrogen bond acceptor, hydrogen bond donor, single electron acceptor, single electron donor, single electron relay |
| A | ALA377 | electrostatic stabiliser |
| A | LEU538 | activator, attractive charge-charge interaction, electrostatic stabiliser, metal ligand |
| A | ASP563 | activator, attractive charge-charge interaction, electrostatic stabiliser, metal ligand |
| A | GLN566 | activator, attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, metal ligand |
| A | ASN569 | activator, attractive charge-charge interaction, electrostatic stabiliser, metal ligand |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 281 |
| Chain | Residue | Details |
| B | GLU92 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| B | ILE341 | activator, hydrogen bond acceptor, hydrogen bond donor, single electron acceptor, single electron donor, single electron relay |
| B | ALA377 | electrostatic stabiliser |
| B | LEU538 | activator, attractive charge-charge interaction, electrostatic stabiliser, metal ligand |
| B | ASP563 | activator, attractive charge-charge interaction, electrostatic stabiliser, metal ligand |
| B | GLN566 | activator, attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, metal ligand |
| B | ASN569 | activator, attractive charge-charge interaction, electrostatic stabiliser, metal ligand |
